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A Potent and Selective Nonpeptide Antagonist of CXCR2 Inhibits Acute and Chronic Models of Arthritis in the Rabbit

The Journal of immunology (1950), 2002-12, Vol.169 (11), p.6435-6444

2002

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Evaluation of Potent and Selective Small-Molecule Antagonists for the CXCR2 Chemokine Receptor

Journal of medicinal chemistry, 2004-03, Vol.47 (6), p.1319-1321

2004

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Comparison of N, N′-diarylsquaramides and N, N′-diarylureas as antagonists of the CXCR2 chemokine receptor

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (6), p.1713-1717

2007

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Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic–Industry Partnership

ACS infectious diseases, 2018-03, Vol.4 (3), p.349-359

2018

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Discovery of (3- endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (16), p.4560-4562

2009

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Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation

ACS infectious diseases, 2019-10, Vol.5 (10), p.1738-1753

2019

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Azepanone-based inhibitors of human cathepsin S: Optimization of selectivity via the P2 substituent

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (15), p.4409-4415

2011

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Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2493-2505

2009

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Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (1), p.114-118

2009

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Tyrosine urea muscarinic acetylcholine receptor antagonists: Achiral quaternary ammonium groups

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (23), p.7087-7091

2012

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Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists

Bioorganic & medicinal chemistry letters, 2012-05, Vol.22 (9), p.3366-3369

2012

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Identification of Potent, Selective Non-peptide CC Chemokine Receptor-3 Antagonist That Inhibits Eotaxin-, Eotaxin-2-, and Monocyte Chemotactic Protein-4-induced Eosinophil Migration

The Journal of biological chemistry, 2000-11, Vol.275 (47), p.36626-36631

2000

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Design, Synthesis, and Structure−Activity Relationship of Tropane Muscarinic Acetylcholine Receptor Antagonists

Journal of medicinal chemistry, 2009-08, Vol.52 (16), p.5241-5252

2009

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3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3864-3867

2007

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An improved and highly convergent synthesis of 4-substituted-pyrido[2,3- d]pyrimidin-7-ones

Tetrahedron letters, 2007-02, Vol.48 (7), p.1205-1207

2007

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N, N′-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (21), p.5513-5516

2006

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Discovery of potent and orally bioavailable N, N′-diarylurea antagonists for the CXCR2 chemokine receptor

Bioorganic & medicinal chemistry letters, 2004-09, Vol.14 (17), p.4375-4378

2004

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Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists

Bioorganic & medicinal chemistry, 2007-11, Vol.17 (22), p.6066-6069

2007

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A Highly Convergent Synthesis of 2-Phenyl Quinoline as Dual Antagonists for NK2 and NK3 Receptors

Synthetic communications, 2005-12, Vol.35 (24), p.3105-3112

2005

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Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1

Bioorganic & medicinal chemistry letters, 2001-06, Vol.11 (11), p.1441-1444

2001

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A silicon-directed aldol condensation. Synthesis of enantiomerically pure anti aldols

Journal of the American Chemical Society, 1990-12, Vol.112 (26), p.9672-9674

1990

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Parallel Hit Progression Strategy Identifies Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation

ACS infectious diseases, 2019-08, Vol.5 (10), p.1738-1753

2019

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Silicon-directed aldol condensation. Evidence for a pseudorotational mechanism

Journal of the American Chemical Society, 1992-03, Vol.114 (7), p.2765-2767

1992

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Silicon-mediated reductive coupling of aldehydes and allylic alcohols. A stereoselective synthesis of tunicaminyluracil

Journal of the American Chemical Society, 1991-12, Vol.113 (25), p.9661-9663

1991

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Design and development of arrayable syntheses to accelerate SAR studies of pyridopyrimidinone and pyrimidopyrimidinone

Tetrahedron letters, 2009-01, Vol.50 (3), p.370-372

2009

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A Potent and Selective Nonpeptide Antagonist of CXCR2 Inhibits Acute and Chronic Models of Arthritis in the Rabbit

Evaluation of Potent and Selective Small-Molecule Antagonists for the CXCR2 Chemokine Receptor

Comparison of N, N′-diarylsquaramides and N, N′-diarylureas as antagonists of the CXCR2 chemokine receptor

Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic–Industry Partnership

Discovery of (3- endo)-3-(2-cyano-2,2-diphenylethyl)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide as an efficacious inhaled muscarinic acetylcholine receptor antagonist for the treatment of COPD

Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation

Azepanone-based inhibitors of human cathepsin S: Optimization of selectivity via the P2 substituent

Discovery of Novel 1-Azoniabicyclo[2.2.2]octane Muscarinic Acetylcholine Receptor Antagonists

Camphor sulfonamide derivatives as novel, potent and selective CXCR3 antagonists

Tyrosine urea muscarinic acetylcholine receptor antagonists: Achiral quaternary ammonium groups

Design, synthesis and structure–activity relationship of N-substituted tropane muscarinic acetylcholine receptor antagonists

Identification of Potent, Selective Non-peptide CC Chemokine Receptor-3 Antagonist That Inhibits Eotaxin-, Eotaxin-2-, and Monocyte Chemotactic Protein-4-induced Eosinophil Migration

Design, Synthesis, and Structure−Activity Relationship of Tropane Muscarinic Acetylcholine Receptor Antagonists

3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists

An improved and highly convergent synthesis of 4-substituted-pyrido[2,3- d]pyrimidin-7-ones

N, N′-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors

Discovery of potent and orally bioavailable N, N′-diarylurea antagonists for the CXCR2 chemokine receptor

Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists

A Highly Convergent Synthesis of 2-Phenyl Quinoline as Dual Antagonists for NK2 and NK3 Receptors

Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1

A silicon-directed aldol condensation. Synthesis of enantiomerically pure anti aldols

Parallel Hit Progression Strategy Identifies Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation

Silicon-directed aldol condensation. Evidence for a pseudorotational mechanism

Silicon-mediated reductive coupling of aldehydes and allylic alcohols. A stereoselective synthesis of tunicaminyluracil

Design and development of arrayable syntheses to accelerate SAR studies of pyridopyrimidinone and pyrimidopyrimidinone

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