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Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery

Journal of medicinal chemistry, 2012-07, Vol.55 (13), p.5989-6001

2012

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Biology-Oriented Synthesis

Angewandte Chemie (International ed.), 2011-11, Vol.50 (46), p.10800-10826

International ed. in English, 2011

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Natural-product-derived fragments for fragment-based ligand discovery

Nature chemistry, 2013-01, Vol.5 (1), p.21-28

2013

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Charting Biologically Relevant Chemical Space: A Structural Classification of Natural Products (SCONP)

Proceedings of the National Academy of Sciences - PNAS, 2005-11, Vol.102 (48), p.17272-17277

2005

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Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

International journal of cancer, 2012-12, Vol.131 (11), p.2704-2709

2012

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Small-molecule inhibition of APT1 affects Ras localization and signaling

Nature chemical biology, 2010-06, Vol.6 (6), p.449-456

2010

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The Scaffold Tree − Visualization of the Scaffold Universe by Hierarchical Scaffold Classification

Journal of chemical information and modeling, 2007-01, Vol.47 (1), p.47-58

2007

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Bioactivity-guided mapping and navigation of chemical space

Nature Chemical Biology, 2009-08, Vol.5 (8), p.585-592

2009

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Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

Angewandte Chemie (International ed.), 2011-10, Vol.50 (42), p.9832-9837

International ed. in English, 2011

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Cheminformatic Analysis of Natural Products and their Chemical Space

Chimia, 2007-01, Vol.61 (6), p.355

2007

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Microarray Strategy for Mapping the Substrate Specificity of Protein Tyrosine Phosphatase

Angewandte Chemie (International ed.), 2007-01, Vol.46 (40), p.7700-7703

2007

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Pelvic Osteoplasty in Osteolytic Metastases: Technical Approach under Fluoroscopic Guidance and Early Clinical Results

Journal of vascular and interventional radiology, 2005, Vol.16 (1), p.81-88

2005

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Interactive exploration of chemical space with Scaffold Hunter

Nature Chemical Biology, 2009-08, Vol.5 (8), p.581-583

2009

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Werte, Worte, Taten: Und wie sie Realitaet in Unternehmen werden. Eine erfolgreiche Kompetenzentwicklung fuer Fuehrungskraefte. 1. Aufl

2007

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Percutaneous vertebroplasty: preliminary experiences with rotational acquisitions and 3D reconstructions for therapy control

Cardiovascular and interventional radiology, 2006-09, Vol.29 (5), p.862-865

2006

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Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

Angewandte Chemie, 2011-10, Vol.123 (42), p.10006-10011

2011

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Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase

Journal of the American Chemical Society, 2012-05, Vol.134 (17), p.7384-7391

2012

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ATP competitive inhibitors of d-alanine– d-alanine ligase based on protein kinase inhibitor scaffolds

Bioorganic & medicinal chemistry, 2009-02, Vol.17 (3), p.1079-1087

2009

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Structure-Guided Development of Selective RabGGTase Inhibitors

Angewandte Chemie (International ed.), 2011-05, Vol.50 (21), p.4957-4961

International ed. in English, 2011

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Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

Angewandte Chemie (International ed.), 2010-05, Vol.49 (21), p.3666-3670

2010

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Design, Synthesis, and Characterization of Peptide-Based Rab Geranylgeranyl Transferase Inhibitors

Journal of medicinal chemistry, 2009-12, Vol.52 (24), p.8025-8037

2009

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Biologie-orientierte Synthese (BIOS)

Angewandte Chemie, 2011-11, Vol.123 (46), p.10990-11018

2011

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Synthesis and Conformational Analysis of Stevastelin C3 Analogues and Their Activity Against the Dual-Specific Vaccina H1-Related Phosphatase

Chemistry : a European journal, 2008-10, Vol.14 (29), p.8847-8860

2008

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Corrigendum: Interactive exploration of chemical space with Scaffold Hunter

Nature chemical biology, 2009-09, Vol.5 (9), p.696-696

2009

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Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery

Biology-Oriented Synthesis

Natural-product-derived fragments for fragment-based ligand discovery

Charting Biologically Relevant Chemical Space: A Structural Classification of Natural Products (SCONP)

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

Small-molecule inhibition of APT1 affects Ras localization and signaling

The Scaffold Tree − Visualization of the Scaffold Universe by Hierarchical Scaffold Classification

High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions

Bioactivity-guided mapping and navigation of chemical space

Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

Cheminformatic Analysis of Natural Products and their Chemical Space

Microarray Strategy for Mapping the Substrate Specificity of Protein Tyrosine Phosphatase

Pelvic Osteoplasty in Osteolytic Metastases: Technical Approach under Fluoroscopic Guidance and Early Clinical Results

Interactive exploration of chemical space with Scaffold Hunter

Werte, Worte, Taten: Und wie sie Realitaet in Unternehmen werden. Eine erfolgreiche Kompetenzentwicklung fuer Fuehrungskraefte. 1. Aufl

Percutaneous vertebroplasty: preliminary experiences with rotational acquisitions and 3D reconstructions for therapy control

Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase

ATP competitive inhibitors of d-alanine– d-alanine ligase based on protein kinase inhibitor scaffolds

Structure-Guided Development of Selective RabGGTase Inhibitors

Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

Design, Synthesis, and Characterization of Peptide-Based Rab Geranylgeranyl Transferase Inhibitors

Biologie-orientierte Synthese (BIOS)

Synthesis and Conformational Analysis of Stevastelin C3 Analogues and Their Activity Against the Dual-Specific Vaccina H1-Related Phosphatase

Corrigendum: Interactive exploration of chemical space with Scaffold Hunter

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