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Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid

Pharmaceutical research, 2016-04, Vol.33 (4), p.856-867

2016

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In Vivo and Ex Vivo Inhibition of Spinal Nerve Ligation-Induced Ectopic Activity by Sodium Channel Blockers Correlate to In Vitro Inhibition of NaV1.7 and Clinical Efficacy: A Pharmacokinetic-Pharmacodynamic Translational Approach

Pharmaceutical research, 2013-05, Vol.30 (5), p.1409-1422

2013

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Systems Pharmacology Modeling of Drug-Induced Modulation of Thyroid Hormones in Dogs and Translation to Human

Pharmaceutical research, 2013-06, Vol.30 (6), p.1513-1524

2013

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Building an adaptive dose simulation framework to aid dose and schedule selection

CPT: pharmacometrics and systems pharmacology, 2023-11, Vol.12 (11), p.1602-1618

2023

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Interplay between α-, β-, and γ-Secretases Determines Biphasic Amyloid-β Protein Level in the Presence of a γ-Secretase Inhibitor

The Journal of biological chemistry, 2013-01, Vol.288 (2), p.785-792

2013

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Model‐based meta‐analysis of non‐small cell lung cancer with standard of care PD‐1 inhibitors and chemotherapy for early development decision making

CPT: pharmacometrics and systems pharmacology, 2023-11, Vol.12 (11), p.1751-1763

2023

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Has inhibition of Aβ production adequately been tested as therapeutic approach in mild AD? A model-based meta-analysis of γ-secretase inhibitor data

European journal of clinical pharmacology, 2013-06, Vol.69 (6), p.1247-1260

2013

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Optimization of human dose prediction by using quantitative and translational pharmacology in drug discovery

Future medicinal chemistry, 2015-01, Vol.7 (17), p.2351-2369

2015

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Validation of a Model Predicting Anti-infective Lung Penetration in the Epithelial Lining Fluid of Humans

Pharmaceutical research, 2018-02, Vol.35 (2), p.26-4, Article 26

2018

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Model‐Informed Drug Discovery and Development: Current Industry Good Practice and Regulatory Expectations and Future Perspectives

CPT: pharmacometrics and systems pharmacology, 2019-02, Vol.8 (2), p.87-96

2019

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Decreased axonal transport rates in the Tg2576 APP transgenic mouse: improvement with the gamma-secretase inhibitor MRK-560 as detected by manganese-enhanced MRI

The European journal of neuroscience, 2012-11, Vol.36 (9), p.3165-3172

2012

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Belantamab mafodotin concentration–QTc relationships in patients with relapsed or refractory multiple myeloma from the DREAMM‐1 and ‐2 studies

British journal of clinical pharmacology, 2024-06

2024

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A Model‐Informed Drug Discovery and Development Strategy for the Novel Glucose‐Responsive Insulin MK‐2640 Enabled Rapid Decision Making

Clinical pharmacology and therapeutics, 2020-06, Vol.107 (6), p.1296-1311

2020

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Population PKPD Modeling of BACE1 Inhibitor-Induced Reduction in Aβ Levels In Vivo and Correlation to In Vitro Potency in Primary Cortical Neurons from Mouse and Guinea Pig

Pharmaceutical research, 2014-03, Vol.31 (3), p.670-683

2014

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Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions

Journal of aerosol medicine and pulmonary drug delivery, 2016-08, Vol.29 (4), p.362

2016

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Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use

Clinical pharmacology and therapeutics, 2018-03, Vol.103 (3), p.378-383

2018

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Clinical Evaluation of MK‐2640: An Insulin Analog With Glucose‐Responsive Properties

Clinical pharmacology and therapeutics, 2019-02, Vol.105 (2), p.417-425

2019

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Toward Progress in Quantitative Translational Medicine: A Call to Action

Clinical pharmacology and therapeutics, 2020-01, Vol.107 (1), p.85-88

2020

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The virtue of translational PKPD modeling in drug discovery: selecting the right clinical candidate while sparing animal lives

Drug discovery today, 2013-09, Vol.18 (17-18), p.853-862

2013

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MID3: Mission Impossible or Model‐Informed Drug Discovery and Development? Point‐Counterpoint Discussions on Key Challenges

Clinical pharmacology and therapeutics, 2020-04, Vol.107 (4), p.762-772

2020

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Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid

British journal of clinical pharmacology, 2016-06, Vol.81 (6), p.1113-1123

2016

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Pharmacokinetic-Pharmacodynamic Modeling of the Inhibitory Effects of Naproxen on the Time-Courses of Inflammatory Pain, Fever, and the Ex Vivo Synthesis of TXB2 and PGE2 in Rats

Pharmaceutical research, 2011-07, Vol.28 (7), p.1561-1576

2011

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Assessment of translational risk in drug research: Role of biomarker classification and mechanism-based PKPD concepts

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.S72-S77

2017

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Model-based drug discovery: implementation and impact

Drug discovery today, 2013-08, Vol.18 (15-16), p.764-775

2013

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Translational pharmacokinetic–pharmacodynamic modeling of QTc effects in dog and human

Journal of pharmacological and toxicological methods, 2013-11, Vol.68 (3), p.357-366

2013

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Structure-Based Prediction of Anti-infective Drug Concentrations in the Human Lung Epithelial Lining Fluid

In Vivo and Ex Vivo Inhibition of Spinal Nerve Ligation-Induced Ectopic Activity by Sodium Channel Blockers Correlate to In Vitro Inhibition of NaV1.7 and Clinical Efficacy: A Pharmacokinetic-Pharmacodynamic Translational Approach

Systems Pharmacology Modeling of Drug-Induced Modulation of Thyroid Hormones in Dogs and Translation to Human

Building an adaptive dose simulation framework to aid dose and schedule selection

Interplay between α-, β-, and γ-Secretases Determines Biphasic Amyloid-β Protein Level in the Presence of a γ-Secretase Inhibitor

Model‐based meta‐analysis of non‐small cell lung cancer with standard of care PD‐1 inhibitors and chemotherapy for early development decision making

Has inhibition of Aβ production adequately been tested as therapeutic approach in mild AD? A model-based meta-analysis of γ-secretase inhibitor data

Optimization of human dose prediction by using quantitative and translational pharmacology in drug discovery

Validation of a Model Predicting Anti-infective Lung Penetration in the Epithelial Lining Fluid of Humans

Model‐Informed Drug Discovery and Development: Current Industry Good Practice and Regulatory Expectations and Future Perspectives

Decreased axonal transport rates in the Tg2576 APP transgenic mouse: improvement with the gamma-secretase inhibitor MRK-560 as detected by manganese-enhanced MRI

Belantamab mafodotin concentration–QTc relationships in patients with relapsed or refractory multiple myeloma from the DREAMM‐1 and ‐2 studies

A Model‐Informed Drug Discovery and Development Strategy for the Novel Glucose‐Responsive Insulin MK‐2640 Enabled Rapid Decision Making

Population PKPD Modeling of BACE1 Inhibitor-Induced Reduction in Aβ Levels In Vivo and Correlation to In Vitro Potency in Primary Cortical Neurons from Mouse and Guinea Pig

Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions

Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use

Clinical Evaluation of MK‐2640: An Insulin Analog With Glucose‐Responsive Properties

Toward Progress in Quantitative Translational Medicine: A Call to Action

The virtue of translational PKPD modeling in drug discovery: selecting the right clinical candidate while sparing animal lives

MID3: Mission Impossible or Model‐Informed Drug Discovery and Development? Point‐Counterpoint Discussions on Key Challenges

Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid

Pharmacokinetic-Pharmacodynamic Modeling of the Inhibitory Effects of Naproxen on the Time-Courses of Inflammatory Pain, Fever, and the Ex Vivo Synthesis of TXB2 and PGE2 in Rats

Assessment of translational risk in drug research: Role of biomarker classification and mechanism-based PKPD concepts

Model-based drug discovery: implementation and impact

Translational pharmacokinetic–pharmacodynamic modeling of QTc effects in dog and human

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