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Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity

Clinical cancer research, 2018-06, Vol.24 (11), p.2631-2641

2018

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Modeling Approach to Predict the Impact of Inflammation on the Pharmacokinetics of CYP2C19 and CYP3A4 Substrates

Pharmaceutical research, 2021-03, Vol.38 (3), p.415-428

2021

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Impact of Interleukin-6 on Drug-Metabolizing Enzymes and Transporters in Intestinal Cells

The AAPS journal, 2019-12, Vol.22 (1), p.16, Article 16

2019

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Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation

Investigational new drugs, 2020-12, Vol.38 (6), p.1796-1806

2020

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A Physiologically Based Pharmacokinetic Model for Strontium Exposure in Rat

Pharmaceutical research, 2013-06, Vol.30 (6), p.1536-1552

2013

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Modeling restoration of gefitinib efficacy by co‐administration of MET inhibitors in an EGFR inhibitor‐resistant NSCLC xenograft model: A tumor‐in‐host DEB‐based approach

CPT: pharmacometrics and systems pharmacology, 2021-11, Vol.10 (11), p.1396-1411

2021

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Bioavailability of three novel oral, sustained‐release pellets, relative to an immediate‐release tablet containing 500 mg flucytosine: A randomized, open‐label, crossover study in healthy volunteers

Clinical and translational science, 2024-03, Vol.17 (3), p.e13756-n/a

2024

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Application of Hematological Toxicity Modeling in Clinical Development of Abexinostat (S-78454, PCI-24781), A New Histone Deacetylase Inhibitor

Pharmaceutical research, 2013-10, Vol.30 (10), p.2640-2653

2013

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Impact of Hepatic CYP3A4 Ontogeny Functions on Drug–Drug Interaction Risk in Pediatric Physiologically‐Based Pharmacokinetic/Pharmacodynamic Modeling: Critical Literature Review and Ivabradine Case Study

Clinical pharmacology and therapeutics, 2021-06, Vol.109 (6), p.1618-1630

2021

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Development of a physiologically-based pharmacokinetic model of the rat central nervous system

Pharmaceutics, 2014-03, Vol.6 (1), p.97-136

2014

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Reduced physiologically-based pharmacokinetic model of dabigatran etexilate-dabigatran and its application for prediction of intestinal P-gp-mediated drug-drug interactions

European journal of pharmaceutical sciences, 2021-10, Vol.165, p.105932-105932, Article 105932

2021

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Pharmacogenetics and population pharmacokinetics: impact of the design on three tests using the SAEM algorithm

Journal of pharmacokinetics and pharmacodynamics, 2009-08, Vol.36 (4), p.317-339

2009

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Virtual patients, digital twins and causal disease models: Paving the ground for in silico clinical trials

Drug discovery today, 2023-07, Vol.28 (7), p.103605-103605, Article 103605

2023

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Simultaneous Ivabradine Parent-Metabolite PBPK/PD Modelling Using a Bayesian Estimation Method

The AAPS journal, 2020-10, Vol.22 (6), Article 129

2020

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Application of Item Response Theory to Model Disease Progression and Agomelatine Effect in Patients with Major Depressive Disorder

The AAPS journal, 2020-01, Vol.22 (1), p.4, Article 4

2020

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How to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an Example

Clinical pharmacology and therapeutics, 2023-02, Vol.113 (2), p.310-320

2023

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Pharmacokinetic Modeling of Free Amoxicillin Concentrations in Rat Muscle Extracellular Fluids Determined by Microdialysis

Antimicrobial Agents and Chemotherapy, 2005-09, Vol.49 (9), p.3702-3706

2005

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Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling

European journal of pharmaceutical sciences, 2017-08, Vol.106, p.122-132

2017

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Impact of interleukin‐6 on drug transporters and permeability in the hCMEC/D3 blood–brain barrier model

Fundamental & clinical pharmacology, 2021-04, Vol.35 (2), p.397-409

2021

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Norfloxacin Blood-Brain Barrier Transport in Rats Is Not Affected by Probenecid Coadministration

Antimicrobial Agents and Chemotherapy, 2006-01, Vol.50 (1), p.371-373

2006

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Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm

Clinical pharmacology and therapeutics, 2021-03, Vol.109 (3), p.605-618

2021

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Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy

Drug metabolism and disposition, 2019-06, Vol.47 (6), p.648-656

2019

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Transforming Translation Through Quantitative Pharmacology for High‐Impact Decision Making in Drug Discovery and Development

Clinical pharmacology and therapeutics, 2020-06, Vol.107 (6), p.1285-1289

2020

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Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use

Clinical pharmacology and therapeutics, 2018-03, Vol.103 (3), p.378-383

2018

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Comparison of Nonlinear Mixed Effects Models and Noncompartmental Approaches in Detecting Pharmacogenetic Covariates

The AAPS journal, 2015-05, Vol.17 (3), p.597-608

2015

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Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity

Modeling Approach to Predict the Impact of Inflammation on the Pharmacokinetics of CYP2C19 and CYP3A4 Substrates

Impact of Interleukin-6 on Drug-Metabolizing Enzymes and Transporters in Intestinal Cells

Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation

A Physiologically Based Pharmacokinetic Model for Strontium Exposure in Rat

Modeling restoration of gefitinib efficacy by co‐administration of MET inhibitors in an EGFR inhibitor‐resistant NSCLC xenograft model: A tumor‐in‐host DEB‐based approach

Bioavailability of three novel oral, sustained‐release pellets, relative to an immediate‐release tablet containing 500 mg flucytosine: A randomized, open‐label, crossover study in healthy volunteers

Application of Hematological Toxicity Modeling in Clinical Development of Abexinostat (S-78454, PCI-24781), A New Histone Deacetylase Inhibitor

Impact of Hepatic CYP3A4 Ontogeny Functions on Drug–Drug Interaction Risk in Pediatric Physiologically‐Based Pharmacokinetic/Pharmacodynamic Modeling: Critical Literature Review and Ivabradine Case Study

Development of a physiologically-based pharmacokinetic model of the rat central nervous system

Reduced physiologically-based pharmacokinetic model of dabigatran etexilate-dabigatran and its application for prediction of intestinal P-gp-mediated drug-drug interactions

Pharmacogenetics and population pharmacokinetics: impact of the design on three tests using the SAEM algorithm

Virtual patients, digital twins and causal disease models: Paving the ground for in silico clinical trials

Simultaneous Ivabradine Parent-Metabolite PBPK/PD Modelling Using a Bayesian Estimation Method

Application of Item Response Theory to Model Disease Progression and Agomelatine Effect in Patients with Major Depressive Disorder

How to Successfully Generate an Alternative Approach to a Thorough QT Study: GLPG1972 as an Example

Pharmacokinetic Modeling of Free Amoxicillin Concentrations in Rat Muscle Extracellular Fluids Determined by Microdialysis

Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling

Impact of interleukin‐6 on drug transporters and permeability in the hCMEC/D3 blood–brain barrier model

Norfloxacin Blood-Brain Barrier Transport in Rats Is Not Affected by Probenecid Coadministration

Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm

Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy

Transforming Translation Through Quantitative Pharmacology for High‐Impact Decision Making in Drug Discovery and Development

Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use

Comparison of Nonlinear Mixed Effects Models and Noncompartmental Approaches in Detecting Pharmacogenetic Covariates

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