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Systems pharmacology – Towards the modeling of network interactions

European journal of pharmaceutical sciences, 2016-10, Vol.94, p.4-14

Danhof, Meindert

2016

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Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations

The AAPS journal, 2017-07, Vol.19 (4), p.891-909

2017

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Pharmacology-based toxicity assessment: towards quantitative risk prediction in humans

Mutagenesis, 2016-05, Vol.31 (3), p.359-374

2016

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Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats

The AAPS journal, 2012-09, Vol.14 (3), p.543-553

2012

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The implications of target saturation for the use of drug-target residence time

Nature reviews. Drug discovery, 2019-01, Vol.18 (1), p.82-84

2019

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A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

Pharmaceutical research, 2017-02, Vol.34 (2), p.333-351

2017

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Maturation of the Glomerular Filtration Rate in Neonates, as Reflected by Amikacin Clearance

Clinical pharmacokinetics, 2012-02, Vol.51 (2), p.105-117

2012

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Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling

DRUG METABOLISM AND PHARMACOKINETICS, 2009-01, Vol.24 (1), p.3-15

2009

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Extensions to the Visual Predictive Check to facilitate model performance evaluation

Journal of pharmacokinetics and pharmacodynamics, 2008-04, Vol.35 (2), p.185-202

2008

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Prediction of methotrexate CNS distribution in different species – Influence of disease conditions

European journal of pharmaceutical sciences, 2014-06, Vol.57, p.11-24

2014

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Predicting Drug Concentration‐Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically‐Based Pharmacokinetic Model

CPT: pharmacometrics and systems pharmacology, 2017-11, Vol.6 (11), p.765-777

2017

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Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults

Journal of clinical pharmacology, 2014-06, Vol.54 (6), p.619-629

2014

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Pharmacokinetic–Pharmacodynamic Modeling of the Effectiveness and Safety of Buprenorphine and Fentanyl in Rats

Pharmaceutical research, 2008-01, Vol.25 (1), p.183-193

2008

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Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients

Therapeutic drug monitoring, 2009-04, Vol.31 (2), p.187

2009

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Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics

The Journal of pharmacology and experimental therapeutics, 2005-06, Vol.313 (3), p.1136

2005

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Developmental pharmacokinetics of propylene glycol in preterm and term neonates

British journal of clinical pharmacology, 2013-01, Vol.75 (1), p.162-171

2013

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Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models

Journal of Pharmacokinetics and Pharmacodynamics, 2015-10, Vol.42 (5), p.447-462

Danhof, Meindert

2015

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Ontogeny of hepatic glucuronidation; methods and results

Current drug metabolism, 2012-07, Vol.13 (6), p.728

2012

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Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling

The AAPS journal, 2017-12, Vol.20 (1), p.11-11, Article 11

2017

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Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers

Anesthesiology (Philadelphia), 2006-06, Vol.104 (6), p.1232-1242

2006

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Sensitivity of the individual items of the Hamilton depression rating scale to response and its consequences for the assessment of efficacy

Journal of psychiatric research, 2008-10, Vol.42 (12), p.1000-1009

2008

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Population Pharmacokinetics and Pharmacodynamics of Propofol in Morbidly Obese Patients

Clinical pharmacokinetics, 2011-11, Vol.50 (11), p.739-750

2011

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Pharmacokinetics of Clindamycin in Pregnant Women in the Peripartum Period

Antimicrobial Agents and Chemotherapy, 2010-05, Vol.54 (5), p.2175-2181

2010

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Pharmacokinetic Modeling of Non-Linear Brain Distribution of Fluvoxamine in the Rat

Pharmaceutical research, 2008-04, Vol.25 (4), p.792-804

2008

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A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying type 2 diabetes mellitus

Journal of pharmacokinetics and pharmacodynamics, 2006-06, Vol.33 (3), p.313-343

2006

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Systems pharmacology – Towards the modeling of network interactions

Microdialysis: the Key to Physiologically Based Model Prediction of Human CNS Target Site Concentrations

Pharmacology-based toxicity assessment: towards quantitative risk prediction in humans

Physiologically Based Pharmacokinetic Modeling to Investigate Regional Brain Distribution Kinetics in Rats

The implications of target saturation for the use of drug-target residence time

A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations

Maturation of the Glomerular Filtration Rate in Neonates, as Reflected by Amikacin Clearance

Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling

Extensions to the Visual Predictive Check to facilitate model performance evaluation

Prediction of methotrexate CNS distribution in different species – Influence of disease conditions

Predicting Drug Concentration‐Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically‐Based Pharmacokinetic Model

Population pharmacokinetics of paracetamol across the human age-range from (pre)term neonates, infants, children to adults

Pharmacokinetic–Pharmacodynamic Modeling of the Effectiveness and Safety of Buprenorphine and Fentanyl in Rats

Explaining variability in tacrolimus pharmacokinetics to optimize early exposure in adult kidney transplant recipients

Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics

Developmental pharmacokinetics of propylene glycol in preterm and term neonates

Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models

Ontogeny of hepatic glucuronidation; methods and results

Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling

Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers

Sensitivity of the individual items of the Hamilton depression rating scale to response and its consequences for the assessment of efficacy

Population Pharmacokinetics and Pharmacodynamics of Propofol in Morbidly Obese Patients

Pharmacokinetics of Clindamycin in Pregnant Women in the Peripartum Period

Pharmacokinetic Modeling of Non-Linear Brain Distribution of Fluvoxamine in the Rat

A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying type 2 diabetes mellitus

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