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Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

Bioconjugate chemistry, 2010-12, Vol.21 (12), p.2153-2163

2010

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Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods

Journal of pharmaceutical sciences, 2009-12, Vol.98 (12), p.4941-4961

2009

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Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism‐Based Prediction of Volume of Distribution

Journal of pharmaceutical sciences, 2002-01, Vol.91 (1), p.129-156

2002

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Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: What have we learned?

mAbs, 2011-01, Vol.3 (1), p.61-66

2011

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Physiologically based pharmacokinetic models of small molecules and therapeutic antibodies: a mini-review on fundamental concepts and applications

Biopharmaceutics & drug disposition, 2016-03, Vol.37 (2), p.75-92

2016

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Prediction of Pharmacokinetics Prior to In Vivo Studies. II. Generic Physiologically Based Pharmacokinetic Models of Drug Disposition

Journal of pharmaceutical sciences, 2002-05, Vol.91 (5), p.1358-1370

2002

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A strategy for risk mitigation of antibodies with fast clearance

mAbs, 2012-11, Vol.4 (6), p.753-760

2012

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Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats

Bioconjugate chemistry, 2011-10, Vol.22 (10), p.1994-2004

2011

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Confounding Parameters in Preclinical Assessment of Blood–Brain Barrier Permeation: An Overview With Emphasis on Species Differences and Effect of Disease States

Molecular pharmaceutics, 2013-05, Vol.10 (5), p.1581-1595

2013

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A possible mechanism for the emergence of an additional band gap due to a Ti-O-C bond in the TiO2-graphene hybrid system for enhanced photodegradation of methylene blue under visible light

RSC advances, 2014, Vol.4 (104), p.59890

2014

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Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins

Journal of Immunology Research, 2016-01, Vol.2016 (2016), p.1-9

2016

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A Priori Prediction of Tissue:Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically‐Based Pharmacokinetic Models in Drug Discovery

Journal of pharmaceutical sciences, 2000-01, Vol.89 (1), p.16-35

2000

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Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

Expert opinion on drug metabolism & toxicology, 2008-09, Vol.4 (9), p.1143-1152

2008

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Maximizing tumour exposure to anti‐neuropilin‐1 antibody requires saturation of non‐tumour tissue antigenic sinks in mice

British journal of pharmacology, 2012-05, Vol.166 (1), p.368-377

2012

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Prediction of adipose tissue: Plasma partition coefficients for structurally unrelated drugs

Journal of pharmaceutical sciences, 2001-04, Vol.90 (4), p.436-447

2001

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Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model

Molecular cancer therapeutics, 2012-03, Vol.11 (3), p.752-762

2012

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Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection

Toxicology letters, 2003-02, Vol.138 (1), p.29-49

2003

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Current challenges and opportunities in nonclinical safety testing of biologics

Drug discovery today, 2013-12, Vol.18 (23-24), p.1138-1143

2013

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Subcutaneous bioavailability of therapeutic antibodies as a function  of FcRn binding affinity in mice

mAbs, 2012-01, Vol.4 (1), p.101-109

2012

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Recent Advances in Assessing Immunogenicity of Therapeutic Proteins: Impact on Biotherapeutic Development

Journal of Immunology Research, 2016-01, Vol.2016, p.8141269-2

2016

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An Algorithm for Evaluating Potential Tissue Drug Distribution in Toxicology Studies from Readily Available Pharmacokinetic Parameters

Journal of pharmaceutical sciences, 2013-10, Vol.102 (10), p.3816-3829

2013

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Effects of anti-VEGF on predicted antibody biodistribution: roles of vascular volume, interstitial volume, and blood flow

PloS one, 2011-03, Vol.6 (3), p.e17874

2011

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Highlights From a Recent BIO Survey on Therapeutic Protein-Drug Interactions

Journal of clinical pharmacology, 2012-11, Vol.52 (11), p.1755-1763

2012

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New challenges and opportunities in nonclinical safety testing of biologics

Regulatory toxicology and pharmacology, 2014-07, Vol.69 (2), p.226-233

2014

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Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods

Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism‐Based Prediction of Volume of Distribution

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: What have we learned?

Physiologically based pharmacokinetic models of small molecules and therapeutic antibodies: a mini-review on fundamental concepts and applications

Prediction of Pharmacokinetics Prior to In Vivo Studies. II. Generic Physiologically Based Pharmacokinetic Models of Drug Disposition

A strategy for risk mitigation of antibodies with fast clearance

Impact of Drug Conjugation on Pharmacokinetics and Tissue Distribution of Anti-STEAP1 Antibody–Drug Conjugates in Rats

Confounding Parameters in Preclinical Assessment of Blood–Brain Barrier Permeation: An Overview With Emphasis on Species Differences and Effect of Disease States

A possible mechanism for the emergence of an additional band gap due to a Ti-O-C bond in the TiO2-graphene hybrid system for enhanced photodegradation of methylene blue under visible light

Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins

A Priori Prediction of Tissue:Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically‐Based Pharmacokinetic Models in Drug Discovery

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development

Maximizing tumour exposure to anti‐neuropilin‐1 antibody requires saturation of non‐tumour tissue antigenic sinks in mice

Prediction of adipose tissue: Plasma partition coefficients for structurally unrelated drugs

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model

Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection

Current challenges and opportunities in nonclinical safety testing of biologics

Subcutaneous bioavailability of therapeutic antibodies as a function  of FcRn binding affinity in mice

Recent Advances in Assessing Immunogenicity of Therapeutic Proteins: Impact on Biotherapeutic Development

An Algorithm for Evaluating Potential Tissue Drug Distribution in Toxicology Studies from Readily Available Pharmacokinetic Parameters

Effects of anti-VEGF on predicted antibody biodistribution: roles of vascular volume, interstitial volume, and blood flow

Highlights From a Recent BIO Survey on Therapeutic Protein-Drug Interactions

New challenges and opportunities in nonclinical safety testing of biologics

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