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The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro-to-In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research

Journal of pharmaceutical sciences, 2016-02, Vol.105 (2), p.497-508

2016

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Advancing Prediction of Tissue Distribution and Volume of Distribution of Highly Lipophilic Compounds from a Simplified Tissue-Composition-Based Model as a Mechanistic Animal Alternative Method

Journal of pharmaceutical sciences, 2012-06, Vol.101 (6), p.2250-2261

2012

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Is Single-stage Revision According to a Strict Protocol Effective in Treatment of Chronic Knee Arthroplasty Infections?

Clinical orthopaedics and related research, 2015-01, Vol.473 (1), p.8-14

2015

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Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes

Journal of pharmaceutical sciences, 2011-10, Vol.100 (10), p.4501-4517

2011

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Supplemental Analysis of the Prediction of Hepatic Clearance of Binary Mixtures of Bisphenol A and Naproxen Determined in an Isolated Perfused Rat Liver Model to Promote the Understanding of Potential Albumin-Facilitated Hepatic Uptake Mechanism

Journal of pharmaceutical sciences, 2017-11, Vol.106 (11), p.3207-3214

2017

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Midterm Assessment of Causes and Results of Revision Total Knee Arthroplasty

Clinical orthopaedics and related research, , Vol.468 (5), p.1221-1228

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Physiological Daily Inhalation Rates for Health Risk Assessment in Overweight/Obese Children, Adults, and Elderly

Risk analysis, 2014-03, Vol.34 (3), p.567-582

2014

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Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies

Journal of pharmaceutical sciences, 2013-08, Vol.102 (8), p.2806-2818

2013

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Human inhalation exposures to toluene, ethylbenzene, and m-xylene and physiologically based pharmacokinetic modeling of exposure biomarkers in exhaled air, blood, and urine

Toxicological sciences, 2015-04, Vol.144 (2), p.414-424

2015

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Second Trimester Ultrasound: Reference Values for Two-Dimensional Speckle Tracking–Derived Longitudinal Strain, Strain Rate and Time to Peak Deformation of the Fetal Heart

Journal of the American Society of Echocardiography, 2012-12, Vol.25 (12), p.1333-1341

2012

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Changes in Fetal Left and Right Ventricular Strain Mechanics during Normal Pregnancy

Journal of the American Society of Echocardiography, 2013-10, Vol.26 (10), p.1193-1200

2013

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Development and Validation of a Method for the Simultaneous Quantification of 21 Microbial Volatile Organic Compounds in Ambient and Exhaled Air by Thermal Desorption and Gas Chromatography–Mass Spectrometry

Atmosphere, 2022-09, Vol.13 (9), p.1432

2022

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CETP inhibitor evacetrapib enters mouse brain tissue

Frontiers in pharmacology, 2023-07, Vol.14, p.1171937-1171937

2023

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Tutorial: methods for three-dimensional visualization of archival tissue material

Nature protocols, 2021-11, Vol.16 (11), p.4945-4962

2021

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A New Guidance for the Prediction of Hepatic Clearance in the Early Drug Discovery and Development from the in Vitro-to-in Vivo Extrapolation Method and an Approach for Exploring Whether an Albumin-Mediated Hepatic Uptake Phenomenon Could be Present Under in Vivo Conditions

Journal of pharmaceutical sciences, 2021-07, Vol.110 (7), p.2841-2858

2021

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Toxicokinetic modeling of persistent organic pollutant levels in blood from birth to 45 months of age in longitudinal birth cohort studies

Environmental health perspectives, 2013-01, Vol.121 (1), p.131-131

2013

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Comparative Assessment of In Vitro–In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs

Journal of pharmaceutical sciences, 2012-11, Vol.101 (11), p.4308-4326

2012

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Early Clinical and Radiological Outcomes of the Metaphyseally Fixed Totally Stabilized Knee Prosthesis in Primary Total Knee Arthroplasty

The Journal of knee surgery, 2020-07, Vol.33 (7), p.678

2020

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Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mechanistic Insights

Journal of pharmaceutical sciences, 2018-07, Vol.107 (7), p.1791-1797

2018

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A Physiologically Based Pharmacokinetic Model for the Assessment of Infant Exposure to Persistent Organic Pollutants in Epidemiologic Studies

Environmental health perspectives, 2009-03, Vol.117 (3), p.481-487

2009

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Albumin and Uptake of Drugs in Cells: Additional Validation Exercises of a Recently Published Equation that Quantifies the Albumin-Facilitated Uptake Mechanism(s) in Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling Research

Journal of pharmaceutical sciences, 2015-12, Vol.104 (12), p.4448-4458

2015

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Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients

Infection and drug resistance, 2020-01, Vol.13, p.1961-1970

2020

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DNA Repair and Immune Response Pathways Are Deregulated in Melanocyte-Keratinocyte Co-cultures Derived From the Healthy Skin of Familial Melanoma Patients

Frontiers in medicine, 2021-10, Vol.8, p.692341-692341

2021

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Evaluating the neurotoxic effects of lactational exposure to persistent organic pollutants (POPs) in Spanish children

Neurotoxicology (Park Forest South), 2013-01, Vol.34, p.9-15

2013

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Toward a new paradigm for the efficient in vitro–in vivo extrapolation of metabolic clearance in humans from hepatocyte data

Journal of pharmaceutical sciences, 2013-09, Vol.102 (9), p.3239-3251

2013

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The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro-to-In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research

Advancing Prediction of Tissue Distribution and Volume of Distribution of Highly Lipophilic Compounds from a Simplified Tissue-Composition-Based Model as a Mechanistic Animal Alternative Method

Is Single-stage Revision According to a Strict Protocol Effective in Treatment of Chronic Knee Arthroplasty Infections?

Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes

Supplemental Analysis of the Prediction of Hepatic Clearance of Binary Mixtures of Bisphenol A and Naproxen Determined in an Isolated Perfused Rat Liver Model to Promote the Understanding of Potential Albumin-Facilitated Hepatic Uptake Mechanism

Midterm Assessment of Causes and Results of Revision Total Knee Arthroplasty

Physiological Daily Inhalation Rates for Health Risk Assessment in Overweight/Obese Children, Adults, and Elderly

Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies

Human inhalation exposures to toluene, ethylbenzene, and m-xylene and physiologically based pharmacokinetic modeling of exposure biomarkers in exhaled air, blood, and urine

Second Trimester Ultrasound: Reference Values for Two-Dimensional Speckle Tracking–Derived Longitudinal Strain, Strain Rate and Time to Peak Deformation of the Fetal Heart

Changes in Fetal Left and Right Ventricular Strain Mechanics during Normal Pregnancy

Development and Validation of a Method for the Simultaneous Quantification of 21 Microbial Volatile Organic Compounds in Ambient and Exhaled Air by Thermal Desorption and Gas Chromatography–Mass Spectrometry

CETP inhibitor evacetrapib enters mouse brain tissue

Tutorial: methods for three-dimensional visualization of archival tissue material

A New Guidance for the Prediction of Hepatic Clearance in the Early Drug Discovery and Development from the in Vitro-to-in Vivo Extrapolation Method and an Approach for Exploring Whether an Albumin-Mediated Hepatic Uptake Phenomenon Could be Present Under in Vivo Conditions

Toxicokinetic modeling of persistent organic pollutant levels in blood from birth to 45 months of age in longitudinal birth cohort studies

Comparative Assessment of In Vitro–In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs

Early Clinical and Radiological Outcomes of the Metaphyseally Fixed Totally Stabilized Knee Prosthesis in Primary Total Knee Arthroplasty

Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mechanistic Insights

A Physiologically Based Pharmacokinetic Model for the Assessment of Infant Exposure to Persistent Organic Pollutants in Epidemiologic Studies

Albumin and Uptake of Drugs in Cells: Additional Validation Exercises of a Recently Published Equation that Quantifies the Albumin-Facilitated Uptake Mechanism(s) in Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling Research

Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients

DNA Repair and Immune Response Pathways Are Deregulated in Melanocyte-Keratinocyte Co-cultures Derived From the Healthy Skin of Familial Melanoma Patients

Evaluating the neurotoxic effects of lactational exposure to persistent organic pollutants (POPs) in Spanish children

Toward a new paradigm for the efficient in vitro–in vivo extrapolation of metabolic clearance in humans from hepatocyte data

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