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Assembly of allosteric macromolecular switches: lessons from PKA

Nature reviews. Molecular cell biology, 2012-10, Vol.13 (10), p.646-658

2012

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Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

Cell, 2013-08, Vol.154 (5), p.1036-1046

2013

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Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

Cell, 2020-09, Vol.182 (6), p.1531-1544.e15

2020

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Dynamic architecture of a protein kinase

Proceedings of the National Academy of Sciences - PNAS, 2014-10, Vol.111 (43), p.E4623-E4631

2014

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Deciphering the structural basis of eukaryotic protein kinase regulation

PLoS biology, 2013-10, Vol.11 (10), p.e1001680

2013

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Defining the conserved internal architecture of a protein kinase

Biochimica et biophysica acta, 2010-03, Vol.1804 (3), p.440-444

2010

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LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains

PLoS biology, 2022-02, Vol.20 (2), p.e3001427-e3001427

2022

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The “violin model”: Looking at community networks for dynamic allostery

The Journal of Chemical Physics, 2023-02, Vol.158 (8), p.081001-081001

2023

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Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

Genes & development, 2013-06, Vol.27 (11), p.1223-1232

2013

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helix scaffold for the assembly of active protein kinases

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (38), p.14377-14382

2008

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AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission

The Journal of neuroscience, 2018-09, Vol.38 (38), p.8233-8242

2018

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Crystal structure of the WD40 domain dimer of LRRK2

Proceedings of the National Academy of Sciences - PNAS, 2019-01, Vol.116 (5), p.1579-1584

2019

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Dynamic allostery-based molecular workings of kinase: peptide complexes

Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (30), p.15052-15061

2019

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How an intrinsically disordered regulatory subunit assembles a PP1:eIF2 complex

Cell reports (Cambridge), 2024-04, Vol.43 (4), p.114011-114011, Article 114011

2024

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ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function

The Journal of biological chemistry, 2011-01, Vol.286 (4), p.2918-2932

2011

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Dynamics connect substrate recognition to catalysis in protein kinase A

Nature chemical biology, 2010-11, Vol.6 (11), p.821-828

2010

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Signaling through dynamic linkers as revealed by PKA

Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (35), p.14231-14236

2013

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Uniform nomenclature for the mitochondrial contact site and cristae organizing system

The Journal of cell biology, 2014-03, Vol.204 (7), p.1083-1086

2014

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Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (17), p.6969-6974

2011

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Surface Comparison of Active and Inactive Protein Kinases Identifies a Conserved Activation Mechanism

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (47), p.17783-17788

2006

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Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase's enzymatic cycle

Nature communications, 2019-02, Vol.10 (1), p.799-799, Article 799

2019

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A dynamic hydrophobic core orchestrates allostery in protein kinases

Science advances, 2017-04, Vol.3 (4), p.e1600663-e1600663

2017

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hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module

Proceedings of the National Academy of Sciences - PNAS, 2007-01, Vol.104 (4), p.1272-1277

2007

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Structural and functional diversity of the microbial kinome

PLoS biology, 2007-03, Vol.5 (3), p.e17-e17

2007

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GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

eLife, 2019-05, Vol.8

2019

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Assembly of allosteric macromolecular switches: lessons from PKA

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

Dynamic architecture of a protein kinase

Deciphering the structural basis of eukaryotic protein kinase regulation

Defining the conserved internal architecture of a protein kinase

LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains

The “violin model”: Looking at community networks for dynamic allostery

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

helix scaffold for the assembly of active protein kinases

AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission

Crystal structure of the WD40 domain dimer of LRRK2

Dynamic allostery-based molecular workings of kinase: peptide complexes

How an intrinsically disordered regulatory subunit assembles a PP1:eIF2 complex

ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function

Dynamics connect substrate recognition to catalysis in protein kinase A

Signaling through dynamic linkers as revealed by PKA

Uniform nomenclature for the mitochondrial contact site and cristae organizing system

Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy

Surface Comparison of Active and Inactive Protein Kinases Identifies a Conserved Activation Mechanism

Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase's enzymatic cycle

A dynamic hydrophobic core orchestrates allostery in protein kinases

hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module

Structural and functional diversity of the microbial kinome

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

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