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Targeting the Insulin-like Growth Factor Receptor-1R Pathway for Cancer Therapy

Clinical cancer research, 2010-05, Vol.16 (9), p.2512-2517

2010

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Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors

Advances in anatomic pathology, 2017-11, Vol.24 (6), p.311-335

2017

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Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research

Advances in anatomic pathology, 2017-09, Vol.24 (5), p.235-251

2017

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Randomized Phase II Trial of Onartuzumab in Combination With Erlotinib in Patients With Advanced Non–Small-Cell Lung Cancer

Journal of clinical oncology, 2013-11, Vol.31 (32), p.4105-4114

2013

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Uniform nomenclature for the mitochondrial contact site and cristae organizing system

The Journal of cell biology, 2014-03, Vol.204 (7), p.1083-1086

2014

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Therapeutic antibody targeting of individual Notch receptors

Nature (London), 2010-04, Vol.464 (7291), p.1052-1057

2010

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An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer

Cancer research (Chicago, Ill.), 2012-11, Vol.72 (22), p.5812-5823

2012

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Evaluation of EML4-ALK Fusion Proteins in Non–Small Cell Lung Cancer Using Small Molecule Inhibitors

Neoplasia (New York, N.Y.), 2011, Vol.13 (1), p.1-IN1

2011

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Somatic mutations lead to an oncogenic deletion of met in lung cancer

Cancer research (Chicago, Ill.), 2006, Vol.66 (1), p.283-289

2006

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The mitochondrial inner membrane protein mitofilin controls cristae morphology

Molecular biology of the cell, 2005-03, Vol.16 (3), p.1543-1554

2005

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MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival

Cancer research (Chicago, Ill.), 2008-06, Vol.68 (11), p.4360-4368

2008

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Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis

Journal for immunotherapy of cancer, 2018-03, Vol.6 (1), p.20-20, Article 20

2018

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Navitoclax Enhances the Efficacy of Taxanes in Non―Small Cell Lung Cancer Models

Clinical cancer research, 2011-03, Vol.17 (6), p.1394-1404

2011

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Posttranslational N-Myristoylation of BID as a Molecular Switch for Targeting Mitochondria and Apoptosis

Science (American Association for the Advancement of Science), 2000-12, Vol.290 (5497), p.1761-1765

2000

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The Double-Histone-Acetyltransferase Complex ATAC Is Essential for Mammalian Development

Molecular and Cellular Biology, 2009-03, Vol.29 (5), p.1176-1188

2009

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Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells

The Journal of biological chemistry, 1999-08, Vol.274 (32), p.22532-22538

1999

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Oncogenic BRAF is required for tumor growth and maintenance in melanoma models

Cancer research (Chicago, Ill.), 2006-01, Vol.66 (2), p.999-1006

2006

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847 Optimal dose selection of ADG126 (a masked anti-CTLA-4 SAFEbody®) with significantly widened therapeutic index compared to ipilimumab in combination with anti-PD-1 antibodies informed by QSP modeling

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A945-A945

2023

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Molecular predictors of response to a humanized anti–insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer

Molecular cancer therapeutics, 2009-08, Vol.8 (8), p.2110-2121

2009

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Bad-Deficient Mice Develop Diffuse Large B Cell Lymphoma

Proceedings of the National Academy of Sciences - PNAS, 2003-08, Vol.100 (16), p.9324-9329

2003

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Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma

Proceedings of the National Academy of Sciences - PNAS, 2007-02, Vol.104 (9), p.3466-3471

2007

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Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

Developmental biology, 2006-02, Vol.290 (1), p.66-80

2006

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Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer

Oncotarget, 2018-05, Vol.9 (33), p.22960-22975

2018

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Characterization of ML-IAP protein stability and physiological role in vivo

Biochemical journal, 2012-11, Vol.447 (3), p.427-436

2012

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Targeting the Insulin-like Growth Factor Receptor-1R Pathway for Cancer Therapy

Randomized Phase II Trial of Onartuzumab in Combination With Erlotinib in Patients With Advanced Non–Small-Cell Lung Cancer

Uniform nomenclature for the mitochondrial contact site and cristae organizing system

Therapeutic antibody targeting of individual Notch receptors

Biomarker Analyses from a Placebo-Controlled Phase II Study Evaluating Erlotinib ± Onartuzumab in Advanced Non-Small Cell Lung Cancer: MET Expression Levels Are Predictive of Patient Benefit

An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer

Evaluation of EML4-ALK Fusion Proteins in Non–Small Cell Lung Cancer Using Small Molecule Inhibitors

Somatic mutations lead to an oncogenic deletion of met in lung cancer

The mitochondrial inner membrane protein mitofilin controls cristae morphology

MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival

Measuring multiple parameters of CD8+ tumor-infiltrating lymphocytes in human cancers by image analysis

Navitoclax Enhances the Efficacy of Taxanes in Non―Small Cell Lung Cancer Models

Posttranslational N-Myristoylation of BID as a Molecular Switch for Targeting Mitochondria and Apoptosis

The Double-Histone-Acetyltransferase Complex ATAC Is Essential for Mammalian Development

Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells

Oncogenic BRAF is required for tumor growth and maintenance in melanoma models

847 Optimal dose selection of ADG126 (a masked anti-CTLA-4 SAFEbody®) with significantly widened therapeutic index compared to ipilimumab in combination with anti-PD-1 antibodies informed by QSP modeling

Molecular predictors of response to a humanized anti–insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer

Bad-Deficient Mice Develop Diffuse Large B Cell Lymphoma

Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation

Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer

Characterization of ML-IAP protein stability and physiological role in vivo

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