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Opioid research in the time of the opioid crisis

British journal of pharmacology, 2023-04, Vol.180 (7), p.793-796

2023

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Challenges for opioid receptor nomenclature: IUPHAR Review 9

British journal of pharmacology, 2015-01, Vol.172 (2), p.317-323

2015

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Disruption of the Na⁺ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (51), p.18369-18374

2014

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Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (26), p.10830-10835

2013

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In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs

Scientific reports, 2022-03, Vol.12 (1), p.5320-12, Article 5320

2022

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The Role of G-proteins and G-protein Regulating Proteins in Depressive Disorders

Frontiers in pharmacology, 2018-11, Vol.9, p.1289-1289

2018

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Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor

eLife, 2018-06, Vol.7

2018

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Opioid receptor interacting proteins and the control of opioid signaling

Current pharmaceutical design, 2013, Vol.19 (42), p.7333-7347

2013

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Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management

Frontiers in molecular neuroscience, 2020-01, Vol.13, p.5-5

2020

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Comparison of the antinociceptive response to morphine and morphine-like compounds in male and female Sprague-Dawley rats

The Journal of pharmacology and experimental therapeutics, 2006-03, Vol.316 (3), p.1195-1201

2006

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Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators

Frontiers in chemistry, 2021-10, Vol.9, p.671483

2021

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Reply to Zhuang et al.: Potential side effects of positive allosteric modulators of the mu-opioid receptor

Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (28)

Traynor, John R

2021

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Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy

Frontiers in pharmacology, 2023-07, Vol.14, p.1230053-1230053

2023

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Allostery at opioid receptors: modulation with small molecule ligands

British journal of pharmacology, 2018-07, Vol.175 (14), p.2846-2856

2018

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The Intriguing Effects of Substituents in the N -Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of "Tail Wags Dog" Experiments

Molecules (Basel, Switzerland), 2020-06, Vol.25 (11), p.2640

2020

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Gi/o-coupled receptors compete for signaling to adenylyl cyclase in SH-SY5Y cells and reduce opioid-mediated cAMP overshoot

Molecular pharmacology, 2011-03, Vol.79 (3), p.461-471

2011

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Nucleus accumbens shell excitability is decreased by methamphetamine self-administration and increased by 5-HT2C receptor inverse agonism and agonism

Neuropharmacology, 2015-02, Vol.89, p.113-121

2015

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Structural insights into µ-opioid receptor activation

Nature (London), 2015-08, Vol.524 (7565), p.315-321

2015

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Identification of Small-Molecule Inhibitors of RGS4 Using a High-Throughput Flow Cytometry Protein Interaction Assay

Molecular pharmacology, 2007-01, Vol.71 (1), p.169-175

2007

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RGS inhibition at Gαi₂ selectively potentiates 5-HT1A-mediated antidepressant effects

Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (24), p.11086-11091

2010

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RGS9-2: probing an intracellular modulator of behavior as a drug target

Trends in pharmacological sciences (Regular ed.), 2009-03, Vol.30 (3), p.105-111

2009

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Structure Activity Relationships of Illicit Fentanyl Analogs

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (16), p.1

2021

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Application of Mixed-Solvent Molecular Dynamics Simulations for Prediction of Allosteric Sites on G Protein-Coupled Receptors

Molecular pharmacology, 2023-05, Vol.103 (5), p.274-285

2023

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Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors

Molecular pharmacology, 2018-02, Vol.93 (2), p.157-167

2018

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Opioid research in the time of the opioid crisis

Challenges for opioid receptor nomenclature: IUPHAR Review 9

Disruption of the Na⁺ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor

Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor

In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs

The Role of G-proteins and G-protein Regulating Proteins in Depressive Disorders

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor

Opioid receptor interacting proteins and the control of opioid signaling

Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling as a Potential Target for Pain Management

Comparison of the antinociceptive response to morphine and morphine-like compounds in male and female Sprague-Dawley rats

Allosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators

Reply to Zhuang et al.: Potential side effects of positive allosteric modulators of the mu-opioid receptor

Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy

Allostery at opioid receptors: modulation with small molecule ligands

The Intriguing Effects of Substituents in the N -Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of "Tail Wags Dog" Experiments

Gi/o-coupled receptors compete for signaling to adenylyl cyclase in SH-SY5Y cells and reduce opioid-mediated cAMP overshoot

Nucleus accumbens shell excitability is decreased by methamphetamine self-administration and increased by 5-HT2C receptor inverse agonism and agonism

Structural insights into µ-opioid receptor activation

Identification of Small-Molecule Inhibitors of RGS4 Using a High-Throughput Flow Cytometry Protein Interaction Assay

RGS inhibition at Gαi₂ selectively potentiates 5-HT1A-mediated antidepressant effects

RGS9-2: probing an intracellular modulator of behavior as a drug target

Structure Activity Relationships of Illicit Fentanyl Analogs

Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects

Application of Mixed-Solvent Molecular Dynamics Simulations for Prediction of Allosteric Sites on G Protein-Coupled Receptors

Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors

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