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The Titration Paradox Turns Pharmacology Upside Down

Clinical pharmacology and therapeutics, 2021-08, Vol.110 (2), p.292-293

2021

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Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Journal for immunotherapy of cancer, 2018-02, Vol.6 (1), p.17-15, Article 17

2018

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Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19

Microbiology spectrum, 2022-04, Vol.10 (2), p.e0216721-e0216721

2022

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Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches

Respiratory research, 2011-04, Vol.12 (53), p.54-54, Article 54

2011

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Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation

Drug metabolism and disposition, 2014-09, Vol.42 (9), p.1367

2014

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Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach

The Journal of pharmacology and experimental therapeutics, 2017-02, Vol.360 (2), p.356

2017

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Individualized treatment strategies for hyperuricemia informed by a semi‐mechanistic exposure‐response model of uric acid dynamics

Physiological reports, 2018-03, Vol.6 (5), p.e13614-n/a

2018

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Input characteristics and bioavailability after administration of immediate and a new extended-release formulation of hydromorphone in healthy volunteers

Anesthesiology (Philadelphia), 2002-10, Vol.97 (4), p.827-836

2002

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Pharmacodynamics of orally administered sustained-release hydromorphone in humans

Anesthesiology (Philadelphia), 2001, Vol.94 (1), p.63-73

2001

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Pharmacokinetic/Pharmacodynamic Modeling in Drug Research and Development

Journal of clinical pharmacology, 2000-12, Vol.40 (12), p.1399-1418

2000

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Fostering Culture and Optimizing Organizational Structure for Implementing Model-Based Drug Development

Journal of clinical pharmacology, 2010-09, Vol.50 (S9), p.146S-150S

2010

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Innovative approaches to clinical development and trial design

Annali dell'Istituto superiore di sanità, 2011, Vol.47 (1), p.8-13

2011

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Communicating With the FDA: The "Third Rail" of a New Model for Drug Development

Journal of clinical pharmacology, 2008-02, Vol.48 (2), p.144-145

2008

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Lumbar Epidural morphine in humans and supraspinal analgesia to experimental heat pain

Anesthesiology (Philadelphia), 2000-02, Vol.92 (2), p.312-324

2000

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A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect

Clinical pharmacology and therapeutics, 1997-01, Vol.61 (1), p.45-58

1997

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The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers

Anesthesiology (Philadelphia), 1993-11, Vol.79 (5), p.881-892

1993

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Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans

Anesthesiology (Philadelphia), 1997-10, Vol.87 (4), p.884-899

1997

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Application of physiologic models to predict the influence of changes in body composition and blood flows on the pharmacokinetics of fentanyl and alfentanil in patients

Anesthesiology (Philadelphia), 1998-03, Vol.88 (3), p.657-667

1998

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Enriched analgesic efficacy studies: An assessment by clinical trial simulation

Contemporary clinical trials, 2006-04, Vol.27 (2), p.165-173

2006

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Characterization and validation of a pharmacokinetic model for controlled‐release oxycodone

British journal of clinical pharmacology, 1996-12, Vol.42 (6), p.747-756

1996

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Drug-disease modeling in the pharmaceutical industry - where mechanistic systems pharmacology and statistical pharmacometrics meet

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.S39-S46

2017

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Exposure‐Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients With Prior Myocardial Infarction

Journal of clinical pharmacology, 2017-05, Vol.57 (5), p.573-583

2017

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Survival prediction using time-evolving tumor load: An approach to rationally design treatment sequencing, staging, and dosing strategies for oncology combinations

Journal of clinical oncology, 2017-05, Vol.35 (15_suppl), p.e20040-e20040

2017

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Getting the dose right : Report from the tenth european federation of pharmaceutical sciences (EUFEPS) conference on optimizing drug development

Journal of pharmacokinetics and pharmacodynamics, 2005-04, Vol.32 (2), p.199-211

2005

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The future of drug development: advancing clinical trial design

Nature reviews. Drug discovery, 2009-12, Vol.8 (12), p.949-957

2009

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The Titration Paradox Turns Pharmacology Upside Down

Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19

Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches

Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation

Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach

Individualized treatment strategies for hyperuricemia informed by a semi‐mechanistic exposure‐response model of uric acid dynamics

Input characteristics and bioavailability after administration of immediate and a new extended-release formulation of hydromorphone in healthy volunteers

Pharmacodynamics of orally administered sustained-release hydromorphone in humans

Pharmacokinetic/Pharmacodynamic Modeling in Drug Research and Development

Fostering Culture and Optimizing Organizational Structure for Implementing Model-Based Drug Development

Innovative approaches to clinical development and trial design

Communicating With the FDA: The "Third Rail" of a New Model for Drug Development

Lumbar Epidural morphine in humans and supraspinal analgesia to experimental heat pain

A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect

The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers

Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans

Application of physiologic models to predict the influence of changes in body composition and blood flows on the pharmacokinetics of fentanyl and alfentanil in patients

Enriched analgesic efficacy studies: An assessment by clinical trial simulation

Characterization and validation of a pharmacokinetic model for controlled‐release oxycodone

Drug-disease modeling in the pharmaceutical industry - where mechanistic systems pharmacology and statistical pharmacometrics meet

Exposure‐Response Analyses Supporting Ticagrelor Dosing Recommendation in Patients With Prior Myocardial Infarction

Survival prediction using time-evolving tumor load: An approach to rationally design treatment sequencing, staging, and dosing strategies for oncology combinations

Getting the dose right : Report from the tenth european federation of pharmaceutical sciences (EUFEPS) conference on optimizing drug development

The future of drug development: advancing clinical trial design

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