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Adaptive Designs for Clinical Trials

The New England journal of medicine, 2016-07, Vol.375 (1), p.65-74

2016

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Adaptive increase in sample size when interim results are promising: A practical guide with examples

Statistics in medicine, 2011-12, Vol.30 (28), p.3267-3284

2011

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Multi-proteomic approach to predict specific cardiovascular events in patients with diabetes and myocardial infarction: findings from the EXAMINE trial

Clinical research in cardiology, 2021-07, Vol.110 (7), p.1006-1019

2021

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Design and Monitoring of Multi-Arm Multi-Stage Clinical Trials

Biometrics, 2017-12, Vol.73 (4), p.1289-1299

2017

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A Gatekeeping Procedure to Test a Primary and a Secondary Endpoint in a Group Sequential Design with Multiple Interim Looks

Biometrics, 2018-03, Vol.74 (1), p.40-48

2018

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Optimal promising zone designs

Biometrical journal, 2019-09, Vol.61 (5), p.1175-1186

2019

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Serial Measurement of High-Sensitivity Troponin I and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus in the EXAMINE Trial (Examination of Cardiovascular Outcomes With Alogliptin Versus Standard of Care)

Circulation (New York, N.Y.), 2017-05, Vol.135 (20), p.1911-1921

2017

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Pathophysiological Sex Differences in Heart Failure Progression After Acute Coronary Syndrome: Insights From the EXAMINE Trial

Journal of cardiac failure, 2023-11

2023

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External validation and extension of the TIMI risk score for heart failure in diabetes for patients with recent acute coronary syndrome: An analysis of the EXAMINE trial

Diabetes, obesity & metabolism, 2023-01, Vol.25 (1), p.229-237

2023

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A Randomized, Controlled Trial of Oral Propranolol in Infantile Hemangioma

The New England journal of medicine, 2015-02, Vol.372 (8), p.735-746

2015

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Adaptive clinical trial designs with pre-specified rules for modifying the sample size: a different perspective

Statistics in medicine, 2013-04, Vol.32 (8), p.1276-1279

Mehta, Cyrus R.

2013

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Relationship of glycated haemoglobin and reported hypoglycaemia to cardiovascular outcomes in patients with type 2 diabetes and recent acute coronary syndrome events: The EXAMINE trial

Diabetes, obesity & metabolism, 2017-05, Vol.19 (5), p.664-671

2017

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Comments on "Some Challenges with Statistical Inference in Adaptive Designs" by Hung, Wang, and Yang

Journal of biopharmaceutical statistics, 2016-03, Vol.26 (2), p.402-404

Mehta, Cyrus R.

2016

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Alogliptin after acute coronary syndrome in patients with type 2 diabetes: a renal function stratified analysis of the EXAMINE trial

BMC medicine, 2020-06, Vol.18 (1), p.165-165, Article 165

2020

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Testing a Primary and a Secondary Endpoint in a Group Sequential Design

Biometrics, 2010-12, Vol.66 (4), p.1174-1184

2010

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Fasiglifam-Induced Liver Injury in Patients With Type 2 Diabetes: Results of a Randomized Controlled Cardiovascular Outcomes Safety Trial

Diabetes care, 2018-12, Vol.41 (12), p.2603-2609

2018

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Reassessing the Role of Surrogate End Points in Drug Development for Heart Failure

Circulation (New York, N.Y.), 2018-09, Vol.138 (10), p.1039-1053

2018

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Influence of sex, age and race on coronary and heart failure events in patients with diabetes and post-acute coronary syndrome

Clinical research in cardiology, 2021-10, Vol.110 (10), p.1612-1624

2021

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Adaptive extensions of a two-stage group sequential procedure for testing primary and secondary endpoints (I): unknown correlation between the endpoints

Statistics in medicine, 2012-08, Vol.31 (19), p.2027-2040

2012

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Efficiency Considerations for Group Sequential Designs with Adaptive Unblinded Sample Size Re-assessment

Statistics in biosciences, 2018-08, Vol.10 (2), p.405-419

2018

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Body weight changes in patients with type 2 diabetes and a recent acute coronary syndrome: an analysis from the EXAMINE trial

Cardiovascular diabetology, 2021-09, Vol.20 (1), p.187-187, Article 187

2021

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The distance of the femoral neurovascular bundle from the hip joint: an intraoperative guide to reduce iatrogenic injury

Journal of orthopaedic surgery and research, 2018-06, Vol.13 (1), p.135-135, Article 135

2018

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Exact Confidence Bounds Following Adaptive Group Sequential Tests

Biometrics, 2009-06, Vol.65 (2), p.539-546

2009

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Adaptive extensions of a two-stage group sequential procedure for testing primary and secondary endpoints (II): sample size re-estimation

Statistics in medicine, 2012-08, Vol.31 (19), p.2041-2054

2012

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Adaptive Designs for Clinical Trials

Adaptive increase in sample size when interim results are promising: A practical guide with examples

Multi-proteomic approach to predict specific cardiovascular events in patients with diabetes and myocardial infarction: findings from the EXAMINE trial

Design and Monitoring of Multi-Arm Multi-Stage Clinical Trials

The potential role and rationale for treatment of heart failure with sodium–glucose co‐transporter 2 inhibitors

A Gatekeeping Procedure to Test a Primary and a Secondary Endpoint in a Group Sequential Design with Multiple Interim Looks

Optimal promising zone designs

Serial Measurement of High-Sensitivity Troponin I and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus in the EXAMINE Trial (Examination of Cardiovascular Outcomes With Alogliptin Versus Standard of Care)

Pathophysiological Sex Differences in Heart Failure Progression After Acute Coronary Syndrome: Insights From the EXAMINE Trial

External validation and extension of the TIMI risk score for heart failure in diabetes for patients with recent acute coronary syndrome: An analysis of the EXAMINE trial

A Randomized, Controlled Trial of Oral Propranolol in Infantile Hemangioma

Adaptive clinical trial designs with pre-specified rules for modifying the sample size: a different perspective

Relationship of glycated haemoglobin and reported hypoglycaemia to cardiovascular outcomes in patients with type 2 diabetes and recent acute coronary syndrome events: The EXAMINE trial

Comments on "Some Challenges with Statistical Inference in Adaptive Designs" by Hung, Wang, and Yang

Alogliptin after acute coronary syndrome in patients with type 2 diabetes: a renal function stratified analysis of the EXAMINE trial

Testing a Primary and a Secondary Endpoint in a Group Sequential Design

Fasiglifam-Induced Liver Injury in Patients With Type 2 Diabetes: Results of a Randomized Controlled Cardiovascular Outcomes Safety Trial

Reassessing the Role of Surrogate End Points in Drug Development for Heart Failure

Influence of sex, age and race on coronary and heart failure events in patients with diabetes and post-acute coronary syndrome

Adaptive extensions of a two-stage group sequential procedure for testing primary and secondary endpoints (I): unknown correlation between the endpoints

Efficiency Considerations for Group Sequential Designs with Adaptive Unblinded Sample Size Re-assessment

Body weight changes in patients with type 2 diabetes and a recent acute coronary syndrome: an analysis from the EXAMINE trial

The distance of the femoral neurovascular bundle from the hip joint: an intraoperative guide to reduce iatrogenic injury

Exact Confidence Bounds Following Adaptive Group Sequential Tests

Adaptive extensions of a two-stage group sequential procedure for testing primary and secondary endpoints (II): sample size re-estimation

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