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Subcellular β-Adrenergic Receptor Signaling in Cardiac Physiology and Disease

Journal of cardiovascular pharmacology, 2022-09, Vol.80 (3), p.334-341

2022

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G-protein βγ subunits as multi-functional scaffolds and transducers in G-protein-coupled receptor signaling

Cellular and molecular life sciences : CMLS, 2019-11, Vol.76 (22), p.4447-4459

2019

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Targeting G protein-coupled receptor signalling by blocking G proteins

Nature reviews. Drug discovery, 2018-11, Vol.17 (11), p.789-803

2018

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Internalized β2-Adrenergic Receptors Oppose PLC-Dependent Hypertrophic Signaling

Circulation research, 2024-07, Vol.135 (2), p.e24

2024

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Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy

Cell, 2013-03, Vol.153 (1), p.216-227

2013

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Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics

Trends in pharmacological sciences (Regular ed.), 2013-05, Vol.34 (5), p.290-298

Smrcka, Alan V

2013

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A universal allosteric mechanism for G protein activation

Molecular cell, 2021-04, Vol.81 (7), p.1384-1396.e6

2021

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Biasing G βγ Downstream Signaling with Gallein Inhibits Development of Morphine Tolerance and Potentiates Morphine-Induced Nociception in a Tolerant State

Molecular pharmacology, 2024-06, Vol.106 (1), p.47

2024

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Role of phospholipase Cε in physiological phosphoinositide signaling networks

Cellular signalling, 2012-06, Vol.24 (6), p.1333-1343

2012

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Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting

Molecular pharmacology, 2011-10, Vol.80 (4), p.551-557

2011

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Identification of the Activity‐Dependent Neuroprotective Protein (ADNP) as a Novel Effector of Gαi1

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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A PACAP-activated network for secretion requires coordination of Ca2+ influx and Ca2+ mobilization

Molecular biology of the cell, 2024-07, Vol.35 (7), p.ar92

2024

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Coincident Regulation of PLC β Signaling by Gq-Coupled and μ -Opioid Receptors Opposes Opioid-Mediated Antinociception

Molecular pharmacology, 2022-12, Vol.102 (6), p.269-279

2022

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Uveal melanoma-associated mutations in PLCβ4 are constitutively activating and promote melanocyte proliferation and tumorigenesis

Science signaling, 2021-12, Vol.14 (713), p.eabj4243

2021

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Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

Molecular pharmacology, 2018-05, Vol.93 (5), p.477-488

2018

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Biophysical characterization of the CXC chemokine receptor 2 ligands

PloS one, 2024-04, Vol.19 (4), p.e0298418-e0298418

2024

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A Small Contribution to a Large System: The Leptin Receptor Complex

The journal of physical chemistry. B, 2023-03, Vol.127 (11), p.2457-2465

2023

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Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites

Immunity (Cambridge, Mass.), 2019-08, Vol.51 (2), p.298-309.e6

2019

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Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection

American journal of physiology. Heart and circulatory physiology, 2022-12, Vol.323 (6), p.H1376-H1387

2022

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Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils

Molecular pharmacology, 2020-03, Vol.97 (3), p.226-236

2020

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A Chemical Biology Approach Demonstrates G Protein βγ Subunits Are Sufficient to Mediate Directional Neutrophil Chemotaxis

The Journal of biological chemistry, 2014-06, Vol.289 (25), p.17791-17801

2014

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Regulation of Phosphatidylinositol-specific Phospholipase C at the Nuclear Envelope in Cardiac Myocytes

Journal of cardiovascular pharmacology, 2015-03, Vol.65 (3), p.203-210

Smrcka, Alan V

2015

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A naturally occurring membrane-anchored Gαs variant, XLαs, activates phospholipase Cβ4

The Journal of biological chemistry, 2022-08, Vol.298 (8), p.102134-102134, Article 102134

2022

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Fingerprinting G protein-coupled receptor signaling

Science signaling, 2015-12, Vol.8 (405), p.fs20

Smrcka, Alan V

2015

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Stabilization of interdomain interactions in G protein α subunits as a determinant of Gαi subtype signaling specificity

The Journal of biological chemistry, 2024-05, Vol.300 (5), p.107211-107211, Article 107211

2024

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Subcellular β-Adrenergic Receptor Signaling in Cardiac Physiology and Disease

G-protein βγ subunits as multi-functional scaffolds and transducers in G-protein-coupled receptor signaling

Targeting G protein-coupled receptor signalling by blocking G proteins

Internalized β2-Adrenergic Receptors Oppose PLC-Dependent Hypertrophic Signaling

Phospholipase Cε Hydrolyzes Perinuclear Phosphatidylinositol 4-Phosphate to Regulate Cardiac Hypertrophy

Molecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics

A universal allosteric mechanism for G protein activation

Biasing G βγ Downstream Signaling with Gallein Inhibits Development of Morphine Tolerance and Potentiates Morphine-Induced Nociception in a Tolerant State

Role of phospholipase Cε in physiological phosphoinositide signaling networks

Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting

Identification of the Activity‐Dependent Neuroprotective Protein (ADNP) as a Novel Effector of Gαi1

A PACAP-activated network for secretion requires coordination of Ca2+ influx and Ca2+ mobilization

Coincident Regulation of PLC β Signaling by Gq-Coupled and μ -Opioid Receptors Opposes Opioid-Mediated Antinociception

Uveal melanoma-associated mutations in PLCβ4 are constitutively activating and promote melanocyte proliferation and tumorigenesis

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

Biophysical characterization of the CXC chemokine receptor 2 ligands

A Small Contribution to a Large System: The Leptin Receptor Complex

Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites

Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils

A Chemical Biology Approach Demonstrates G Protein βγ Subunits Are Sufficient to Mediate Directional Neutrophil Chemotaxis

Regulation of Phosphatidylinositol-specific Phospholipase C at the Nuclear Envelope in Cardiac Myocytes

A naturally occurring membrane-anchored Gαs variant, XLαs, activates phospholipase Cβ4

Fingerprinting G protein-coupled receptor signaling

Stabilization of interdomain interactions in G protein α subunits as a determinant of Gαi subtype signaling specificity

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