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Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Science (American Association for the Advancement of Science), 2020-06, Vol.368 (6498), p.1499-1504

2020

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Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

Nature communications, 2021-06, Vol.12 (1), p.3623-3623, Article 3623

2021

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Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2

Cell research, 2021-11, Vol.31 (11), p.1212-1214

2021

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SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target

Cell research, 2021-08, Vol.31 (8), p.847-860

2021

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Biological Activities of Artemisinin Derivatives Beyond Malaria

Current topics in medicinal chemistry, 2019-01, Vol.19 (3), p.205-222

2019

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The complete synthesis of favipiravir from 2-aminopyrazine

Chemical papers, 2019-05, Vol.73 (5), p.1043-1051

2019

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Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir

Nature communications, 2023-10, Vol.14 (1), p.6463-6463, Article 6463

2023

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Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus

Neurobiology of learning and memory, 2020-01, Vol.167, p.107136, Article 107136

2020

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Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model

Signal transduction and targeted therapy, 2022-04, Vol.7 (1), p.123-123, Article 123

2022

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Astemizole Arrests the Proliferation of Cancer Cells by Disrupting the EZH2-EED Interaction of Polycomb Repressive Complex 2

Journal of medicinal chemistry, 2014-11, Vol.57 (22), p.9512-9521

2014

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9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation

Inflammation, 2021-10, Vol.44 (5), p.1793-1802

2021

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Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir, Its Parent Nucleoside and β-d-N4-hydroxycytidine

Virologica Sinica, 2021-10, Vol.36 (5), p.997-1005

2021

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An Improved and Practical Synthesis of Rivaroxaban

Heterocycles, 2022-10, Vol.104 (10), p.1854

2022

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Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors

Journal of medicinal chemistry, 2011-08, Vol.54 (15), p.5607-5611

2011

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Combination of miR159 Mimics and Irinotecan Utilizing Lipid Nanoparticles for Enhanced Treatment of Colorectal Cancer

Pharmaceutics, 2024-04, Vol.16 (4), p.570

2024

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A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir

Signal transduction and targeted therapy, 2023-09, Vol.8 (1), p.360-360, Article 360

2023

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The novel small-molecule TPN10456 inhibits Th17 cell differentiation and protects against experimental autoimmune encephalomyelitis

Cellular & molecular immunology, 2020-12, Vol.17 (12), p.1290-1293

2020

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Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review

Current drug targets, 2016-01, Vol.17 (13), p.1560-1576

2016

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Impurity study of tecovirimat

Heliyon, 2024-05, Vol.10 (9), p.e29559-e29559, Article e29559

2024

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Direct esterification of amides by the dimethylsulfate-mediated activation of amide C-N bonds

Communications chemistry, 2024-04, Vol.7 (1), p.93-93, Article 93

2024

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Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity

Journal of chemical information and modeling, 2010-04, Vol.50 (4), p.615-625

2010

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Repurposing of Rutan showed effective treatment for COVID-19 disease

Frontiers in medicine, 2023-11, Vol.10, p.1310129-1310129

2023

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Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2

Signal transduction and targeted therapy, 2023-04, Vol.8 (1), p.169-8, Article 169

2023

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Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives

Journal of medicinal chemistry, 2020-12, Vol.63 (24), p.15153-15186

2020

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Synthesis of telmisartan via oxidative cyclization

Tetrahedron, 2023-01, Vol.130, p.133168, Article 133168

2023

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Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease

Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target

Biological Activities of Artemisinin Derivatives Beyond Malaria

The complete synthesis of favipiravir from 2-aminopyrazine

Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir

Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus

Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model

Astemizole Arrests the Proliferation of Cancer Cells by Disrupting the EZH2-EED Interaction of Polycomb Repressive Complex 2

9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation

Significant Inhibition of Porcine Epidemic Diarrhea Virus In Vitro by Remdesivir, Its Parent Nucleoside and β-d-N4-hydroxycytidine

An Improved and Practical Synthesis of Rivaroxaban

Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors

Combination of miR159 Mimics and Irinotecan Utilizing Lipid Nanoparticles for Enhanced Treatment of Colorectal Cancer

A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir

The novel small-molecule TPN10456 inhibits Th17 cell differentiation and protects against experimental autoimmune encephalomyelitis

Nucleoside Inhibitors of Hepatitis C Virus NS5B Polymerase: A Systematic Review

Impurity study of tecovirimat

Direct esterification of amides by the dimethylsulfate-mediated activation of amide C-N bonds

Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity

Repurposing of Rutan showed effective treatment for COVID-19 disease

Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2

Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives

Synthesis of telmisartan via oxidative cyclization

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