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Amyloid beta： structure, biology and structure-based therapeutic development

Acta pharmacologica Sinica, 2017-09, Vol.38 (9), p.1205-1235

2017

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Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin

Nature structural & molecular biology, 2021-03, Vol.28 (3), p.319-325

2021

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Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

Nature communications, 2020-02, Vol.11 (1), p.807-807, Article 807

2020

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Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Science (American Association for the Advancement of Science), 2020-06, Vol.368 (6498), p.1499-1504

2020

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Structure and dynamics of the active human parathyroid hormone receptor-1

Science (American Association for the Advancement of Science), 2019-04, Vol.364 (6436), p.148-153

2019

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Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy

Nature communications, 2020-08, Vol.11 (1), p.4121-4121, Article 4121

2020

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Structural biology of G protein‐coupled receptor signaling complexes

Protein science, 2019-03, Vol.28 (3), p.487-501

2019

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A complex structure of arrestin-2 bound to a G protein-coupled receptor

Cell research, 2019-12, Vol.29 (12), p.971-983

2019

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Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor

Nature communications, 2021-08, Vol.12 (1), p.5064-5064, Article 5064

2021

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Structural basis of leukotriene B4 receptor 1 activation

Nature communications, 2022-03, Vol.13 (1), p.1156-1156, Article 1156

2022

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Structural insights into the peptide selectivity and activation of human neuromedin U receptors

Nature communications, 2022-04, Vol.13 (1), p.2045-2045, Article 2045

2022

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Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex

Cell, 2020-02, Vol.180 (4), p.645-654.e13

2020

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Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors

Nature communications, 2022-02, Vol.13 (1), p.1057-1057, Article 1057

2022

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Structure and Physiological Regulation of AMPK

International journal of molecular sciences, 2018-11, Vol.19 (11), p.3534

2018

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Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2

Nature communications, 2022-02, Vol.13 (1), p.1054-1054, Article 1054

2022

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Androgen receptor： structure, role in prostate cancer and drug discovery

Acta pharmacologica Sinica, 2015-01, Vol.36 (1), p.3-23

2015

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MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function

Molecular and cellular biology, 2014-11, Vol.34 (22), p.4130-4142

2014

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Structural basis for the tethered peptide activation of adhesion GPCRs

Nature (London), 2022-04, Vol.604 (7907), p.763-770

2022

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Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2

Cell research, 2021-11, Vol.31 (11), p.1212-1214

2021

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Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins

Nature communications, 2020-03, Vol.11 (1), p.1598-1598, Article 1598

2020

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Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B

Nature (London), 2020-10, Vol.586 (7827), p.151-155

2020

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Structural basis for molecular recognition of folic acid by folate receptors

Nature (London), 2013-08, Vol.500 (7463), p.486-489

2013

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Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor

Nature chemical biology, 2021-12, Vol.17 (12), p.1238-1244

2021

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Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

Nature communications, 2021-06, Vol.12 (1), p.3763-3763, Article 3763

2021

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Molecular mechanisms of fentanyl mediated β-arrestin biased signaling

PLoS computational biology, 2020-04, Vol.16 (4), p.e1007394-e1007394

2020

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Amyloid beta： structure, biology and structure-based therapeutic development

Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir

Structure and dynamics of the active human parathyroid hormone receptor-1

Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy

Structural biology of G protein‐coupled receptor signaling complexes

A complex structure of arrestin-2 bound to a G protein-coupled receptor

Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor

Structural basis of leukotriene B4 receptor 1 activation

Structural insights into the peptide selectivity and activation of human neuromedin U receptors

Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex

Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors

Structure and Physiological Regulation of AMPK

Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2

Androgen receptor： structure, role in prostate cancer and drug discovery

MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function

Structural basis for the tethered peptide activation of adhesion GPCRs

Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2

Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins

Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B

Structural basis for molecular recognition of folic acid by folate receptors

Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

Molecular mechanisms of fentanyl mediated β-arrestin biased signaling

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