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Abstract 4396: Conjugation site modulates the stability and biological activity of antibody drug conjugates

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.4396-4396

2010

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Abstract 696: Anti-NRP1 tumor uptake is impacted by normal tissue sinks in a tumor bearing mouse model

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.696-696

2010

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Abstract A136: Nonclinical disposition, metabolism, and in vitro drug-drug interaction assessment of DM1, a component of trastuzumab emtansine (T-DM1)

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.A136-A136

2011

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Abstract LB242: Characterizing the fate<tissue distribution and excretion route> of cancer vaccine lipoplex-RNA following intravenous injection of 14C-DOTMA-lipoplex-mRNA in mice

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (8_Supplement), p.LB242-LB242

2023

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Anti-Lymphocyte Antigen 6 Complex, Locus E- Seco -Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α 1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals

Drug metabolism and disposition, 2020-12, Vol.48 (12), p.1247-1256

2020

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Bioanalytical approaches for characterizing catabolism of antibody-drug conjugates

Bioanalysis, 2015-01, Vol.7 (13), p.1583-1604

2015

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A case study on Sema3E-Fc aggregation and assay-dependent differences in quantitation

Bioanalysis, 2012-03, Vol.4 (6), p.703-711

2012

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Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism

Current drug metabolism, 2012-09, Vol.13 (7), p.901-910

2012

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Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti- Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats

Drug metabolism and disposition, 2020-11, Vol.48 (11), p.1161-1168

2020

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ChemInform Abstract: A Copper‐Catalyzed Domino Reaction to Construct Functionalized Indolizinones

ChemInform, 2016-03, Vol.47 (15), p.no-no

2016

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Clinical pharmacology strategies to accelerate the development of polatuzumab vedotin and summary of key findings

Advanced drug delivery reviews, 2024-04, Vol.207, p.115193, Article 115193

2024

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Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

Pharmacology research & perspectives, 2020-04, Vol.8 (2), p.e00573-n/a

2020

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A copper-catalyzed domino reaction to construct functionalized indolizinones

RSC advances, 2015, Vol.5 (121), p.100097-100101

2015

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A copper-catalyzed domino reaction to construct functionalized indolizinonesElectronic supplementary information (ESI) available: Synthetic procedures of indolizinones, and copies of NMR spectra of all new compounds. CCDC 1428333 and 1428334. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5ra20119e

2015-11

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Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

mAbs, 2014-11, Vol.6 (6), p.1631-1637

2014

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Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

mAbs, 2014, Vol.6 (6), p.1631-1637

2014

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Effect of immune complex formation on the distribution of a novel antibody to the ovarian tumor antigen CA125

Drug metabolism and disposition, 2010-12, Vol.38 (12), p.2309-2319

2010

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Effects of Lovastatin on Trafficking of Cystic Fibrosis Transmembrane Conductance Regulator in Human Tracheal Epithelium (∗)

The Journal of biological chemistry, 1995-10, Vol.270 (42), p.25102-25106

1995

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Effects of lovastatin on trafficking of cystic fibrosis transmembrane conductance regulator in human tracheal epithelium

The Journal of biological chemistry, 1996-01, Vol.271 (2), p.1250-1250

1996

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Exaggerated Hypotensive Effect of Vascular Endothelial Growth Factor in Spontaneously Hypertensive Rats

Hypertension (Dallas, Tex. 1979), 2002-03, Vol.39 (3), p.815-820

2002

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Hepatocyte growth factor stimulates the differentiation of human tracheal epithelia in vitro

American journal of physiology. Lung cellular and molecular physiology, 1997-06, Vol.16 (6), p.L1115-L1120

1997

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Hepatocyte growth factor stimulates the differentiation of human tracheal epithelia in vitro

American journal of physiology. Lung cellular and molecular physiology, 1997-06, Vol.272 (6), p.1115-L1120

1997

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Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4

mAbs, 2011-07, Vol.3 (4), p.376-386

2011

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Abstract 4396: Conjugation site modulates the stability and biological activity of antibody drug conjugates

Abstract 696: Anti-NRP1 tumor uptake is impacted by normal tissue sinks in a tumor bearing mouse model

Abstract A136: Nonclinical disposition, metabolism, and in vitro drug-drug interaction assessment of DM1, a component of trastuzumab emtansine (T-DM1)

Abstract LB242: Characterizing the fate<tissue distribution and excretion route> of cancer vaccine lipoplex-RNA following intravenous injection of 14C-DOTMA-lipoplex-mRNA in mice

Anti-Lymphocyte Antigen 6 Complex, Locus E- Seco -Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α 1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals

Bioanalytical approaches for characterizing catabolism of antibody-drug conjugates

A case study on Sema3E-Fc aggregation and assay-dependent differences in quantitation

Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism

Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti- Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats

ChemInform Abstract: A Copper‐Catalyzed Domino Reaction to Construct Functionalized Indolizinones

Clinical pharmacology strategies to accelerate the development of polatuzumab vedotin and summary of key findings

Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

A copper-catalyzed domino reaction to construct functionalized indolizinones

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice

Effect of immune complex formation on the distribution of a novel antibody to the ovarian tumor antigen CA125

Effects of Lovastatin on Trafficking of Cystic Fibrosis Transmembrane Conductance Regulator in Human Tracheal Epithelium (∗)

Effects of lovastatin on trafficking of cystic fibrosis transmembrane conductance regulator in human tracheal epithelium

Exaggerated Hypotensive Effect of Vascular Endothelial Growth Factor in Spontaneously Hypertensive Rats

Hepatocyte growth factor stimulates the differentiation of human tracheal epithelia in vitro

Hepatocyte growth factor stimulates the differentiation of human tracheal epithelia in vitro

Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4

A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides

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