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Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954

International journal of molecular sciences, 2023-03, Vol.24 (6), p.5987

2023

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Viral gene therapy strategies: from basic science to clinical application

The Journal of pathology, 2006-01, Vol.208 (2), p.299-318

2006

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Minimal RB-responsive E1A Promoter Modification to Attain Potency, Selectivity, and Transgene-arming Capacity in Oncolytic Adenoviruses

Molecular therapy, 2010-11, Vol.18 (11), p.1960-1971

2010

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Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells

International immunology, 2007-12, Vol.19 (12), p.1383-1394

2007

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Vectors based on reducible polycations facilitate intracellular release of nucleic acids

The journal of gene medicine, 2003-03, Vol.5 (3), p.232-245

2003

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Oxygen‐insensitive nitroreductase E. coli NfsA, but not NfsB, is inhibited by fumarate

Proteins, structure, function, and bioinformatics, 2023-05, Vol.91 (5), p.585-592

2023

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Virus-Directed Enzyme Prodrug Therapy: Intratumoral Administration of a Replication-Deficient Adenovirus Encoding Nitroreductase to Patients With Resectable Liver Cancer

Journal of clinical oncology, 2004-05, Vol.22 (9), p.1546-1552

2004

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The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN

Biochemical journal, 2021-07, Vol.478 (13), p.2601-2617

2021

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The 3D‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism

FEBS letters, 2022-09, Vol.596 (18), p.2425-2440

2022

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CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus

Molecular cancer, 2010-03, Vol.9 (1), p.52-52, Article 52

2010

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A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984

Molecular therapy, 2009-07, Vol.17 (7), p.1292-1299

2009

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A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984]

Molecular therapy, 2009-07, Vol.17 (7), p.1292-1299

2009

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Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme

The Journal of biological chemistry, 2005-04, Vol.280 (14), p.13256-13264

2005

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Long-term proliferation of functional human NK cells, with conversion of CD56(dim) NK cells to a CD56 (bright) phenotype, induced by carcinoma cells co-expressing 4-1BBL and IL-12

Cancer immunology, immunotherapy, 2012-05, Vol.61 (5), p.615-628

2012

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Human Leukocyte Antigen (HLA) A1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma

Cancer immunology research, 2015-10, Vol.3 (10), p.1138-1147

2015

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Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs

Bioorganic & medicinal chemistry letters, 2011-07, Vol.21 (13), p.3986-3991

2011

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Kinetic and Structural Characterisation of Escherichia coli Nitroreductase Mutants Showing Improved Efficacy for the Prodrug Substrate CB1954

Journal of molecular biology, 2007-04, Vol.368 (2), p.481-492

2007

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Steady-State and Stopped-Flow Kinetic Studies of Three Escherichia coli NfsB Mutants with Enhanced Activity for the Prodrug CB1954

Biochemistry (Easton), 2009-08, Vol.48 (32), p.7665-7672

2009

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Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer : Construction and testing of a tissue-specific adenovirus vector

Cancer research (Chicago, Ill.), 2000-01, Vol.60 (2), p.334-341

2000

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Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: Effects of combining beneficial single mutations

Biochemical pharmacology, 2010-01, Vol.79 (2), p.102-111

2010

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4-1BBL costimulation retrieves CD28 expression in activated T cells

Cellular immunology, 2009, Vol.256 (1), p.39-46

2009

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Synergistic anti-tumor effects of nitroreductase mutants and p53

Journal of cancer research and therapeutics, 2014-07, Vol.10 (3), p.665-670

2014

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NITROREDUCTASE: A PRODRUG-ACTIVATING ENZYME FOR CANCER GENE THERAPY

Clinical and experimental pharmacology & physiology, 2004-11, Vol.31 (11), p.811-816

2004

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Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954

Cancer research (Chicago, Ill.), 2003-09, Vol.63 (17), p.5532-5537

2003

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The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 Å, 1.8 Å and 2.4 Å resolution

Journal of molecular biology, 2001-05, Vol.309 (1), p.203-213

2001

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Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954

Viral gene therapy strategies: from basic science to clinical application

Minimal RB-responsive E1A Promoter Modification to Attain Potency, Selectivity, and Transgene-arming Capacity in Oncolytic Adenoviruses

Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells

Vectors based on reducible polycations facilitate intracellular release of nucleic acids

Oxygen‐insensitive nitroreductase E. coli NfsA, but not NfsB, is inhibited by fumarate

Virus-Directed Enzyme Prodrug Therapy: Intratumoral Administration of a Replication-Deficient Adenovirus Encoding Nitroreductase to Patients With Resectable Liver Cancer

The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN

The 3D‐structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP+ provide glimpses of its catalytic mechanism

CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus

A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984

A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984]

Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme

Long-term proliferation of functional human NK cells, with conversion of CD56(dim) NK cells to a CD56 (bright) phenotype, induced by carcinoma cells co-expressing 4-1BBL and IL-12

Human Leukocyte Antigen (HLA) A1101-Restricted Epstein-Barr Virus-Specific T-cell Receptor Gene Transfer to Target Nasopharyngeal Carcinoma

Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs

Kinetic and Structural Characterisation of Escherichia coli Nitroreductase Mutants Showing Improved Efficacy for the Prodrug Substrate CB1954

Steady-State and Stopped-Flow Kinetic Studies of Three Escherichia coli NfsB Mutants with Enhanced Activity for the Prodrug CB1954

Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer : Construction and testing of a tissue-specific adenovirus vector

Testing double mutants of the enzyme nitroreductase for enhanced cell sensitisation to prodrugs: Effects of combining beneficial single mutations

4-1BBL costimulation retrieves CD28 expression in activated T cells

Synergistic anti-tumor effects of nitroreductase mutants and p53

NITROREDUCTASE: A PRODRUG-ACTIVATING ENZYME FOR CANCER GENE THERAPY

Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954

The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 Å, 1.8 Å and 2.4 Å resolution

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