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Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction

Medicinal chemistry research, 2020-05, Vol.29 (5), p.846-867

2020

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Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

Medicinal research reviews, 2012-07, Vol.32 (4), p.687-726

2012

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Insects: an underrepresented resource for the discovery of biologically active natural products

Acta pharmaceutica Sinica. B, 2017-07, Vol.7 (4), p.409-426

2017

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Design of anticancer prodrugs for reductive activation

Medicinal research reviews, 2009-01, Vol.29 (1), p.29-64

2009

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Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

Acta pharmaceutica Sinica. B, 2015-07, Vol.5 (4), p.285-299

2015

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Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations

Medicinal chemistry research, 2022, Vol.31 (10), p.1647-1662

2022

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Message from the new Editor-in-Chief

Medicinal chemistry research, 2020-02, Vol.29 (2), p.179-179

Hu, Longqin (Long)

2020

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Design, synthesis, and structure–activity relationships of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as inhibitors of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) immune checkpoint pathway

Medicinal chemistry research, 2022-10, Vol.31 (10), p.1716-1739

2022

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Design, Synthesis, Evaluation, and Structural Studies of C2-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction

Journal of medicinal chemistry, 2019-08, Vol.62 (15), p.7250-7263

2019

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Synthesis and evaluation of new peptide-linked doxorubicin conjugates as prodrugs activated by prostate-specific antigen

Medicinal chemistry research, 2020-07, Vol.29 (7), p.1280-1299

2020

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Immunomodulators targeting the PD‐1/PD‐L1 protein‐protein interaction: From antibodies to small molecules

Medicinal research reviews, 2019-01, Vol.39 (1), p.265-301

2019

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Synthesis and evaluation of new 4-peptidamido-2-fluorobenzyl phosphoramide mustard conjugates as prodrugs activated by prostate-specific antigen

Medicinal chemistry research, 2020-07, Vol.29 (7), p.1264-1279

2020

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Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors

Medicinal chemistry research, 2023-07, Vol.32 (7), p.1391-1399

2023

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Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

Bioorganic & medicinal chemistry letters, 2013-05, Vol.23 (10), p.3039-3043

2013

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Design, synthesis, and evaluation of potential carbamate prodrugs of 5′-methylthioadenosine (MTA)

Medicinal chemistry research, 2021-07, Vol.30 (7), p.1358-1365

2021

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In honor of Professor Robert P. Hanzlik on the occasion of his retirement

Medicinal chemistry research, 2020-07, Vol.29 (7), p.1091-1092

2020

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Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction

Journal of biomolecular screening, 2012-04, Vol.17 (4), p.435-447

2012

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Special issue of Medicinal Chemistry Research in honor of Professor Gary L. Grunewald

Medicinal chemistry research, 2021-07, Vol.30 (7), p.1317-1320

2021

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Potent Inhibitors of Human Organic Anion Transporters 1 and 3 from Clinical Drug Libraries: Discovery and Molecular Characterization

Molecular pharmaceutics, 2012-11, Vol.9 (11), p.3340-3346

2012

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Exploiting the Drug-Activating Properties of a Novel Trypanosomal Nitroreductase

Antimicrobial Agents and Chemotherapy, 2010-03, Vol.54 (3), p.1193-1199

2010

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Efficient Baylis−Hillman Reaction Using Stoichiometric Base Catalyst and an Aqueous Medium

Journal of organic chemistry, 2001-08, Vol.66 (16), p.5413-5418

2001

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Targeted Prodrug Approaches for Hormone Refractory Prostate Cancer

Medicinal research reviews, 2015-05, Vol.35 (3), p.554-585

2015

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Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation

Bioorganic & medicinal chemistry letters, 2012-11, Vol.22 (21), p.6583-6586

2012

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Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction

Bioorganic & medicinal chemistry, 2020-03, Vol.28 (6), p.115343, Article 115343

2020

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Successful Baylis−Hillman Reaction of Acrylamide with Aromatic Aldehydes

Journal of organic chemistry, 2002-01, Vol.67 (1), p.219-223

2002

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Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction

Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents

Insects: an underrepresented resource for the discovery of biologically active natural products

Design of anticancer prodrugs for reductive activation

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations

Message from the new Editor-in-Chief

Design, synthesis, and structure–activity relationships of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as inhibitors of the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) immune checkpoint pathway

Design, Synthesis, Evaluation, and Structural Studies of C2-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction

Synthesis and evaluation of new peptide-linked doxorubicin conjugates as prodrugs activated by prostate-specific antigen

Immunomodulators targeting the PD‐1/PD‐L1 protein‐protein interaction: From antibodies to small molecules

Synthesis and evaluation of new 4-peptidamido-2-fluorobenzyl phosphoramide mustard conjugates as prodrugs activated by prostate-specific antigen

Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors

Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction

Design, synthesis, and evaluation of potential carbamate prodrugs of 5′-methylthioadenosine (MTA)

In honor of Professor Robert P. Hanzlik on the occasion of his retirement

Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction

Special issue of Medicinal Chemistry Research in honor of Professor Gary L. Grunewald

Potent Inhibitors of Human Organic Anion Transporters 1 and 3 from Clinical Drug Libraries: Discovery and Molecular Characterization

Exploiting the Drug-Activating Properties of a Novel Trypanosomal Nitroreductase

Efficient Baylis−Hillman Reaction Using Stoichiometric Base Catalyst and an Aqueous Medium

Targeted Prodrug Approaches for Hormone Refractory Prostate Cancer

Design, synthesis, and evaluation of potential prodrugs of DFMO for reductive activation

Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction

Successful Baylis−Hillman Reaction of Acrylamide with Aromatic Aldehydes

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