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Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Journal for immunotherapy of cancer, 2018-02, Vol.6 (1), p.17-15, Article 17

2018

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Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19

Microbiology spectrum, 2022-04, Vol.10 (2), p.e0216721-e0216721

2022

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Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation

Drug metabolism and disposition, 2014-09, Vol.42 (9), p.1367

2014

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Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches

Respiratory research, 2011-04, Vol.12 (53), p.54-54, Article 54

2011

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The Titration Paradox Turns Pharmacology Upside Down

Clinical pharmacology and therapeutics, 2021-08, Vol.110 (2), p.292-293

2021

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Input characteristics and bioavailability after administration of immediate and a new extended-release formulation of hydromorphone in healthy volunteers

Anesthesiology (Philadelphia), 2002-10, Vol.97 (4), p.827-836

2002

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Pharmacodynamics of orally administered sustained-release hydromorphone in humans

Anesthesiology (Philadelphia), 2001, Vol.94 (1), p.63-73

2001

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Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach

The Journal of pharmacology and experimental therapeutics, 2017-02, Vol.360 (2), p.356

2017

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Lumbar Epidural morphine in humans and supraspinal analgesia to experimental heat pain

Anesthesiology (Philadelphia), 2000-02, Vol.92 (2), p.312-324

2000

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Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans

Anesthesiology (Philadelphia), 1997-10, Vol.87 (4), p.884-899

1997

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Individualized treatment strategies for hyperuricemia informed by a semi‐mechanistic exposure‐response model of uric acid dynamics

Physiological reports, 2018-03, Vol.6 (5), p.e13614-n/a

2018

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A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect

Clinical pharmacology and therapeutics, 1997-01, Vol.61 (1), p.45-58

1997

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The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers

Anesthesiology (Philadelphia), 1993-11, Vol.79 (5), p.881-892

1993

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Fostering Culture and Optimizing Organizational Structure for Implementing Model-Based Drug Development

Journal of clinical pharmacology, 2010-09, Vol.50 (S9), p.146S-150S

2010

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Communicating With the FDA: The "Third Rail" of a New Model for Drug Development

Journal of clinical pharmacology, 2008-02, Vol.48 (2), p.144-145

2008

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Characterization and validation of a pharmacokinetic model for controlled‐release oxycodone

British journal of clinical pharmacology, 1996-12, Vol.42 (6), p.747-756

1996

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Pharmacokinetic-pharmacodynamic modeling in drug development: Application to the investigational opioid trefentanil

Clinical pharmacology and therapeutics, 1994-09, Vol.56 (3), p.261-271

1994

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Enriched analgesic efficacy studies: An assessment by clinical trial simulation

Contemporary clinical trials, 2006-04, Vol.27 (2), p.165-173

2006

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Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat

The Journal of pharmacology and experimental therapeutics, 1997-12, Vol.283 (3), p.1051

1997

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Inadequate anaesthesia in lethal injection for execution

The Lancet (British edition), 2005-09, Vol.366 (9491), p.1073-1073

Groner, Jonathan I

2005

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Getting the dose right : Report from the tenth european federation of pharmaceutical sciences (EUFEPS) conference on optimizing drug development

Journal of pharmacokinetics and pharmacodynamics, 2005-04, Vol.32 (2), p.199-211

2005

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Electroencephalographic effects of benzodiazepines. II. Pharmacodynamic modeling of the electroencephalographic effects of midazolam and diazepam

Clinical pharmacology and therapeutics, 1990-11, Vol.48 (5), p.555-567

1990

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Gerry???s Real World Guide to Pharmacokinetics and Other Things

Anesthesia and analgesia, 2006-03, Vol.102 (3), p.977

Stanski, Donald R.

2006

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Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development

Clinical pharmacology and therapeutics, 1992-04, Vol.51 (4), p.465-473

1992

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Thiopental pharmacodynamics. I: Defining the pseudo-steady state-serum concentration-EEG effect relationship

Anesthesiology (Philadelphia), 1992-08, Vol.77 (2), p.226-236

1992

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Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model

Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19

Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation

Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches

The Titration Paradox Turns Pharmacology Upside Down

Input characteristics and bioavailability after administration of immediate and a new extended-release formulation of hydromorphone in healthy volunteers

Pharmacodynamics of orally administered sustained-release hydromorphone in humans

Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach

Lumbar Epidural morphine in humans and supraspinal analgesia to experimental heat pain

Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans

Individualized treatment strategies for hyperuricemia informed by a semi‐mechanistic exposure‐response model of uric acid dynamics

A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect

The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers

Fostering Culture and Optimizing Organizational Structure for Implementing Model-Based Drug Development

Communicating With the FDA: The "Third Rail" of a New Model for Drug Development

Characterization and validation of a pharmacokinetic model for controlled‐release oxycodone

Pharmacokinetic-pharmacodynamic modeling in drug development: Application to the investigational opioid trefentanil

Enriched analgesic efficacy studies: An assessment by clinical trial simulation

Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat

Inadequate anaesthesia in lethal injection for execution

Getting the dose right : Report from the tenth european federation of pharmaceutical sciences (EUFEPS) conference on optimizing drug development

Electroencephalographic effects of benzodiazepines. II. Pharmacodynamic modeling of the electroencephalographic effects of midazolam and diazepam

Gerry???s Real World Guide to Pharmacokinetics and Other Things

Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development

Thiopental pharmacodynamics. I: Defining the pseudo-steady state-serum concentration-EEG effect relationship

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