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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Nature communications, 2020-10, Vol.11 (1), p.5047-5047, Article 5047

2020

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Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance

The Journal of biological chemistry, 2009-01, Vol.284 (2), p.1202-1212

2009

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Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Journal of visualized experiments, 2021-05 (171)

2021

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Crystal Structures of Complexes of Bacterial dd-Peptidases with Peptidoglycan-Mimetic Ligands: The Substrate Specificity Puzzle

Journal of molecular biology, 2008-08, Vol.381 (2), p.383-393

2008

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SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Cell stem cell, 2022-02, Vol.29 (2), p.217-231.e8

2022

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Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding

Journal of molecular biology, 2006-05, Vol.359 (1), p.122-136

2006

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Turning high-throughput structural biology into predictive inhibitor design

Proceedings of the National Academy of Sciences - PNAS, 2023-03, Vol.120 (11), p.e2214168120-e2214168120

2023

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Crystallographic fragment screening of SARS-CoV-2 drug discovery targets

Acta crystallographica. Section A, Foundations and advances, 2021-08, Vol.77 (a2), p.C196-C196

2021

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Crystal Structures of the Lytic Transglycosylase MltA from N. gonorrhoeae and E. coli : Insights into Interdomain Movements and Substrate Binding

Journal of molecular biology, 2006-05, Vol.359 (1), p.122-136

2006

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Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

Science advances, 2021-04, Vol.7 (16)

2021

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Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic ResistanceS

The Journal of biological chemistry, 2009-01, Vol.284 (2), p.1202-1212

2009

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Structural Studies on a Broad-Specifity Alcohol Dehydrogenase

Powell, Ailsa J

2002

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Tu1762 A CORE TRANSCRIPTIONAL RESISTOME, CHARACTERISED BY NEUTROPHIL DEGRANULATION AND EXTRACELLULAR MATRIX DYSREGULATION, PREDICTS RESISTANCE TO MULTIPLE THERAPIES IN UC

Gastroenterology (New York, N.Y. 1943), 2024-05, Vol.166 (5), p.S-1411-S-1411

2024

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Sa1859 EXTRACELLULAR MATRIX DYSREGULATION AND NEUTROPHIL DEGRANULATION ARE CORE PATHWAYS DRIVING TREATMENT RESISTANCE IN ULCERATIVE COLITIS

Gastroenterology (New York, N.Y. 1943), 2023-05, Vol.164 (6), p.S-466-S-466

2023

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Tu1761 GENE CORRELATION NETWORK ANALYSES REVEAL TRANSCRIPT MODULES AND PATHOGENIC MECHANISMS ASSOCIATED WITH RESISTANCE AND RESPONSE TO USTEKINUMAB THERAPY IN ULCERATIVE COLITIS

Gastroenterology (New York, N.Y. 1943), 2024-05, Vol.166 (5), p.S-1410-S-1410

2024

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O29 A core transcriptional resistome, characterised by neutrophil degranulation and extracellular matrix dysregulation, predicts resistance to multiple therapies in UC

Gut, 2024-06, Vol.73 (Suppl 1), p.A16-A17

2024

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Systematic review: the association between the gut microbiota and medical therapies in inflammatory bowel disease

Alimentary pharmacology & therapeutics, 2022-01, Vol.55 (1), p.26-48

2022

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COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP): a multicentre, prospective, case-control study

The lancet. Gastroenterology & hepatology, 2022-04, Vol.7 (4), p.342-352

2022

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O39 IL22 producing iNKT and CD4+ T-cells drive dysregulation of the extracellular matrix in perianal fistulas

Gut, 2022-06, Vol.71 (Suppl 1), p.A23-A23

2022

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Su1117: HARNESSING TRANSCRIPTOMIC PROFILING TO DEFINE THE BIOLOGICAL MECHANISMS CONTRIBUTING TO PERIANAL FISTULIZING DISEASE

Gastroenterology (New York, N.Y. 1943), 2022-05, Vol.162 (7), p.S-509-S-509

2022

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Dance movement psychotherapy intervention protocol for the caregivers of children on the autism spectrum: Development and fidelity evaluation

The Arts in psychotherapy, 2023-11, Vol.86, p.102082, Article 102082

2023

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The impact of COVID-19 lockdown measures on older residents' social connections and everyday wellbeing within housing schemes that provide care and support in England and Wales

Journal of aging studies, 2023-06, Vol.65, p.101126-101126, Article 101126

2023

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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Crystal Structures of Complexes of Bacterial dd-Peptidases with Peptidoglycan-Mimetic Ligands: The Substrate Specificity Puzzle

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Crystal structures of the lytic transglycosylase MltA from N.gonorrhoeae and E.coli: insights into interdomain movements and substrate binding

Turning high-throughput structural biology into predictive inhibitor design

Crystallographic fragment screening of SARS-CoV-2 drug discovery targets

Crystal Structures of the Lytic Transglycosylase MltA from N. gonorrhoeae and E. coli : Insights into Interdomain Movements and Substrate Binding

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic ResistanceS

Structural Studies on a Broad-Specifity Alcohol Dehydrogenase

British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic

Tu1762 A CORE TRANSCRIPTIONAL RESISTOME, CHARACTERISED BY NEUTROPHIL DEGRANULATION AND EXTRACELLULAR MATRIX DYSREGULATION, PREDICTS RESISTANCE TO MULTIPLE THERAPIES IN UC

Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab

Sa1859 EXTRACELLULAR MATRIX DYSREGULATION AND NEUTROPHIL DEGRANULATION ARE CORE PATHWAYS DRIVING TREATMENT RESISTANCE IN ULCERATIVE COLITIS

Tu1761 GENE CORRELATION NETWORK ANALYSES REVEAL TRANSCRIPT MODULES AND PATHOGENIC MECHANISMS ASSOCIATED WITH RESISTANCE AND RESPONSE TO USTEKINUMAB THERAPY IN ULCERATIVE COLITIS

O29 A core transcriptional resistome, characterised by neutrophil degranulation and extracellular matrix dysregulation, predicts resistance to multiple therapies in UC

Vaccine escape, increased breakthrough and reinfection in infliximab-treated patients with IBD during the Omicron wave of the SARS-CoV-2 pandemic

Systematic review: the association between the gut microbiota and medical therapies in inflammatory bowel disease

COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP): a multicentre, prospective, case-control study

O39 IL22 producing iNKT and CD4+ T-cells drive dysregulation of the extracellular matrix in perianal fistulas

Su1117: HARNESSING TRANSCRIPTOMIC PROFILING TO DEFINE THE BIOLOGICAL MECHANISMS CONTRIBUTING TO PERIANAL FISTULIZING DISEASE

Dance movement psychotherapy intervention protocol for the caregivers of children on the autism spectrum: Development and fidelity evaluation

The impact of COVID-19 lockdown measures on older residents' social connections and everyday wellbeing within housing schemes that provide care and support in England and Wales

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