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Local Drug Delivery for the Treatment of Neurotology Disorders

Frontiers in cellular neuroscience, 2019-06, Vol.13, p.238-238

2019

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Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear

Frontiers in cellular neuroscience, 2019-07, Vol.13, p.347-347

2019

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Hearing loss: The final frontier of pharmacology

Pharmacology research & perspectives, 2022-06, Vol.10 (3), p.e00970-n/a

2022

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Dose-Dependent Sustained Release of Dexamethasone in Inner Ear Cochlear Fluids Using a Novel Local Delivery Approach

Audiology & neurotology, 2009-01, Vol.14 (6), p.393-401

2009

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Synthesis, Structure−Activity Relationships, and Characterization of Novel Nonsteroidal and Selective Androgen Receptor Modulators

Journal of medicinal chemistry, 2009-11, Vol.52 (22), p.7186-7191

2009

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Sa1892 COMBINATION THERAPY OF THE FXR AGONIST FXR314 WITH TOFACITINIB IN MODELS OF INFLAMMATORY BOWEL DISEASE

Gastroenterology (New York, N.Y. 1943), 2024-05, Vol.166 (5), p.S-568-S-568

2024

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Identification of the First Synthetic Steroidogenic Factor 1 Inverse Agonists: Pharmacological Modulation of Steroidogenic Enzymes

Molecular pharmacology, 2008-03, Vol.73 (3), p.900-908

2008

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EVALUATION OF THE CLINICAL STAGE FXR AGONIST FXR314 IN HUMAN PRIMARY CELL 3D MODELS OF CROHN’S DISEASE AND ULCERATIVE COLITIS

Gastroenterology (New York, N.Y. 1943), 2024-02, Vol.166 (3), p.S80-S81

2024

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Broad modulation of neuropathic pain states by a selective estrogen receptor beta agonist

European journal of pharmacology, 2008-08, Vol.590 (1), p.423-429

2008

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EVALUATION OF THE CLINICAL STAGE FXR AGONIST FXR314 IN HUMAN PRIMARY CELL 3D MODELS OF CROHN’S DISEASE AND ULCERATIVE COLITIS

Inflammatory bowel diseases, 2024-01, Vol.30 (Supplement_1), p.S59-S59

2024

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Discovery of a Potent, Orally Available, and Isoform-Selective Retinoic Acid β2 Receptor Agonist

Journal of medicinal chemistry, 2005-12, Vol.48 (24), p.7517-7519

2005

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AP-1 Repressor Protein JDP-2: Inhibition of UV-Mediated Apoptosis through p53 Down-Regulation

Molecular and Cellular Biology, 2001-05, Vol.21 (9), p.3012-3024

2001

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Identification of novel subtype selective RAR agonists

Biochemical pharmacology, 2005-12, Vol.71 (1), p.156-162

2005

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A neurotrophic approach to treating hearing loss: Translation from animal models to clinical proof-of-concepta

The Journal of the Acoustical Society of America, 2022-06, Vol.151 (6), p.3937-3946

2022

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Monitoring Interactions between Receptor Tyrosine Kinases and Their Downstream Effector Proteins in Living Cells Using Bioluminescence Resonance Energy Transfer

Molecular pharmacology, 2007-12, Vol.72 (6), p.1440-1446

2007

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Integrative functional assays, chemical genomics and high throughput screening: harnessing signal transduction pathways to a common HTS readout

Current pharmaceutical design, 2006-05, Vol.12 (14), p.1717

2006

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A neurotrophic approach to treating hearing loss: Translation from animal models to clinical proof-of-concept

The Journal of the Acoustical Society of America, 2022-06, Vol.151 (6), p.3937-3946

2022

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Pharmacology and Signaling Properties of Epidermal Growth Factor Receptor Isoforms Studied by Bioluminescence Resonance Energy Transfer

Molecular pharmacology, 2007-02, Vol.71 (2), p.508-518

2007

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Distribution of Dexamethasone and Preservation of Inner Ear Function following Intratympanic Delivery of a Gel-Based Formulation

Audiology & neurotology, 2011-01, Vol.16 (5), p.323-335

2011

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Dissection of the cytoplasmic domains of cytokine receptors involved in STAT and Ras dependent proliferation

Oncogene, 2002-05, Vol.21 (22), p.3579-3591

2002

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The Sustained-Exposure Dexamethasone Formulation OTO-104 Offers Effective Protection against Cisplatin-Induced Hearing Loss

Audiology & neurotology, 2016-01, Vol.21 (1), p.22-29

2016

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Intratympanic Administration of OTO-313 Reduces Tinnitus in Patients With Moderate to Severe, Persistent Tinnitus: A Phase 1/2 Study

Otology & neurotology, 2021-12, Vol.42 (10), p.e1625

2021

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Dexamethasone and Dexamethasone Phosphate Entry into Perilymph Compared for Middle Ear Applications in Guinea Pigs

Audiology & neurotology, 2018-01, Vol.23 (4), p.245-257

2018

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Principles of inner ear sustained release following intratympanic administration

The Laryngoscope, 2011-02, Vol.121 (2), p.385-391

2011

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The Sustained-Exposure Dexamethasone Formulation OTO-104 Offers Effective Protection against Noise-Induced Hearing Loss

Audiology & neurotology, 2016-01, Vol.21 (1), p.12-21

2016

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Local Drug Delivery for the Treatment of Neurotology Disorders

Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear

Hearing loss: The final frontier of pharmacology

Dose-Dependent Sustained Release of Dexamethasone in Inner Ear Cochlear Fluids Using a Novel Local Delivery Approach

Synthesis, Structure−Activity Relationships, and Characterization of Novel Nonsteroidal and Selective Androgen Receptor Modulators

Sa1892 COMBINATION THERAPY OF THE FXR AGONIST FXR314 WITH TOFACITINIB IN MODELS OF INFLAMMATORY BOWEL DISEASE

Identification of the First Synthetic Steroidogenic Factor 1 Inverse Agonists: Pharmacological Modulation of Steroidogenic Enzymes

EVALUATION OF THE CLINICAL STAGE FXR AGONIST FXR314 IN HUMAN PRIMARY CELL 3D MODELS OF CROHN’S DISEASE AND ULCERATIVE COLITIS

Broad modulation of neuropathic pain states by a selective estrogen receptor beta agonist

EVALUATION OF THE CLINICAL STAGE FXR AGONIST FXR314 IN HUMAN PRIMARY CELL 3D MODELS OF CROHN’S DISEASE AND ULCERATIVE COLITIS

Discovery of a Potent, Orally Available, and Isoform-Selective Retinoic Acid β2 Receptor Agonist

AP-1 Repressor Protein JDP-2: Inhibition of UV-Mediated Apoptosis through p53 Down-Regulation

Identification of novel subtype selective RAR agonists

A neurotrophic approach to treating hearing loss: Translation from animal models to clinical proof-of-concepta

Monitoring Interactions between Receptor Tyrosine Kinases and Their Downstream Effector Proteins in Living Cells Using Bioluminescence Resonance Energy Transfer

Integrative functional assays, chemical genomics and high throughput screening: harnessing signal transduction pathways to a common HTS readout

A neurotrophic approach to treating hearing loss: Translation from animal models to clinical proof-of-concept

Pharmacology and Signaling Properties of Epidermal Growth Factor Receptor Isoforms Studied by Bioluminescence Resonance Energy Transfer

Distribution of Dexamethasone and Preservation of Inner Ear Function following Intratympanic Delivery of a Gel-Based Formulation

Dissection of the cytoplasmic domains of cytokine receptors involved in STAT and Ras dependent proliferation

The Sustained-Exposure Dexamethasone Formulation OTO-104 Offers Effective Protection against Cisplatin-Induced Hearing Loss

Intratympanic Administration of OTO-313 Reduces Tinnitus in Patients With Moderate to Severe, Persistent Tinnitus: A Phase 1/2 Study

Dexamethasone and Dexamethasone Phosphate Entry into Perilymph Compared for Middle Ear Applications in Guinea Pigs

Principles of inner ear sustained release following intratympanic administration

The Sustained-Exposure Dexamethasone Formulation OTO-104 Offers Effective Protection against Noise-Induced Hearing Loss

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