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Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes

Cell chemical biology, 2019-11, Vol.26 (11), p.1559-1572.e9

2019

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High-throughput screening: new technology for the 21st century

Current Opinion in Chemical Biology, 2000-08, Vol.4 (4), p.445-451

2000

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Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor

ACS combinatorial science, 2015-12, Vol.17 (12), p.722-731

2015

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Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic–Industry Partnership

ACS infectious diseases, 2018-03, Vol.4 (3), p.349-359

2018

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Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens

Journal of biomolecular screening, 2012-12, Vol.17 (10), p.1279-1292

2012

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Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation

ACS infectious diseases, 2019-10, Vol.5 (10), p.1738-1753

2019

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A novel approach applying a chemical biology strategy in phenotypic screening reveals pathway-selective regulators of histone 3 K27 tri-methylation

Molecular bioSystems, 2014-02, Vol.10 (2), p.251-257

2014

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A High-Content Imaging Screen for Cellular Regulators of β-Catenin Protein Abundance

Journal of biomolecular screening, 2016-03, Vol.21 (3), p.260-268

2016

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Single-molecule detection technologies in miniaturized high-throughput screening: fluorescence intensity distribution analysis

Journal of biomolecular screening, 2003-02, Vol.8 (1), p.19-33

2003

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The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase

Bioorganic & medicinal chemistry letters, 2002-11, Vol.12 (21), p.3171-3174

2002

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Perspectives on the discovery of small-molecule modulators for epigenetic processes

Journal of biomolecular screening, 2012-06, Vol.17 (5), p.555-571

2012

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SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp: I. Fermentation, Isolation and Properties

The Journal of Antibiotics, 2000/04/25, Vol.53(4), pp.345-350

2000

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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens

Journal of medicinal chemistry, 2002-05, Vol.45 (10), p.1959-1962

2002

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Development of phenotypic screening assays for γ-globin induction using primary human bone marrow day 7 erythroid progenitor cells

Journal of biomolecular screening, 2013-12, Vol.18 (10), p.1212-1222

2013

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Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase

The Journal of Antibiotics, 2000/11/25, Vol.53(11), pp.1282-1292

2000

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Rational Design of Femtomolar Inhibitors of Isoleucyl tRNA Synthetase from a Binding Model for Pseudomonic Acid-A

Biochemistry (Easton), 2000-05, Vol.39 (20), p.6003-6011

2000

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Fluorescence correlation spectroscopy: lead discovery by miniaturized HTS

Drug discovery today, 1998-10, Vol.3 (10), p.457-465

1998

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Kinetics of the vacuolar H+-pyrophosphatase. The roles of magnesium, pyrophosphate, and their complexes as substrates, activators, and inhibitors

Plant physiology (Bethesda), 1992-12, Vol.100 (4), p.1698-1705

1992

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Developments in fluorescence lifetime-based analysis for ultra-HTS

Drug Discovery Today, 2001, Vol.6 (12), p.27-39

2001

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Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1265-1268

2003

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Single-Molecule Detection Technologies in Miniaturized High Throughput Screening: Binding Assays for G Protein–Coupled Receptors Using Fluorescence Intensity Distribution Analysis and Fluorescence Anisotropy

SLAS discovery, 2001-02, Vol.6 (1), p.29-37

2001

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Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Nature communications, 2017-07, Vol.8 (1), p.16081-16081, Article 16081

2017

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Introduction LANCE™ vs. HTRF® Technologies (or Vice Versa)

SLAS discovery, 1999-12, Vol.4 (6), p.301-302

Pope, Andrew J.

1999

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Real experiences of uHTS: a prototypic 1536-well fluorescence anisotropy-based uHTS screen and application of well-level quality control procedures

Journal of biomolecular screening, 2001-10, Vol.6 (5), p.275-290

2001

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A standard operating procedure for assessing liquid handler performance in high-throughput screening

Journal of biomolecular screening, 2002-12, Vol.7 (6), p.554-569

2002

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Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes

High-throughput screening: new technology for the 21st century

Cell-Based Selection Expands the Utility of DNA-Encoded Small-Molecule Library Technology to Cell Surface Drug Targets: Identification of Novel Antagonists of the NK3 Tachykinin Receptor

Inhibitors of LexA Autoproteolysis and the Bacterial SOS Response Discovered by an Academic–Industry Partnership

Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens

Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation

A novel approach applying a chemical biology strategy in phenotypic screening reveals pathway-selective regulators of histone 3 K27 tri-methylation

A High-Content Imaging Screen for Cellular Regulators of β-Catenin Protein Abundance

Single-molecule detection technologies in miniaturized high-throughput screening: fluorescence intensity distribution analysis

The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase

Perspectives on the discovery of small-molecule modulators for epigenetic processes

SB-219383, a Novel Tyrosyl tRNA Synthetase Inhibitor from a Micromonospora sp: I. Fermentation, Isolation and Properties

Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens

Development of phenotypic screening assays for γ-globin induction using primary human bone marrow day 7 erythroid progenitor cells

Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase

Rational Design of Femtomolar Inhibitors of Isoleucyl tRNA Synthetase from a Binding Model for Pseudomonic Acid-A

Fluorescence correlation spectroscopy: lead discovery by miniaturized HTS

Kinetics of the vacuolar H+-pyrophosphatase. The roles of magnesium, pyrophosphate, and their complexes as substrates, activators, and inhibitors

Developments in fluorescence lifetime-based analysis for ultra-HTS

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity

Single-Molecule Detection Technologies in Miniaturized High Throughput Screening: Binding Assays for G Protein–Coupled Receptors Using Fluorescence Intensity Distribution Analysis and Fluorescence Anisotropy

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Introduction LANCE™ vs. HTRF® Technologies (or Vice Versa)

Real experiences of uHTS: a prototypic 1536-well fluorescence anisotropy-based uHTS screen and application of well-level quality control procedures

A standard operating procedure for assessing liquid handler performance in high-throughput screening

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