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HBV replication inhibitors

Antiviral research, 2020-07, Vol.179, p.104815-104815, Article 104815

2020

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The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2′-α-chloro-2′-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors

Bioorganic & medicinal chemistry letters, 2017-09, Vol.27 (18), p.4323-4330

2017

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Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase

Bioorganic & medicinal chemistry letters, 2016-09, Vol.26 (18), p.4536-4541

2016

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Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

Antimicrobial Agents and Chemotherapy, 2001-01, Vol.45 (1), p.229-235

2001

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2′-C-Methyl Branched Pyrimidine Ribonucleoside Analogues: Potent Inhibitors of RNA Virus Replication

Antiviral chemistry & chemotherapy, 2007-08, Vol.18 (4), p.225-242

2007

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Synthesis and Pharmacokinetics of Valopicitabine (NM283), an Efficient Prodrug of the Potent Anti-HCV Agent 2‘-C-Methylcytidine

Journal of medicinal chemistry, 2006-11, Vol.49 (22), p.6614-6620

2006

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Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor

Bioorganic & medicinal chemistry letters, 2017-06, Vol.27 (11), p.2634-2640

2017

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Corrigendum to “Synthesis of unnatural 3′-phospha-2′-deoxyfuranose nucleoside analogues” [Tetrahedron Lett. 55 (2014) 6328–6330]

Tetrahedron letters, 2015-04, Vol.56 (15), p.2035-2035

2015

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Synthesis of Unnatural Phosphonosugar Analogues

European journal of organic chemistry, 2014-02, Vol.2014 (6), p.1333-1337

2014

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Corrigendum to “Synthesis of unnatural 2- and 3-deoxyfuranose analogues” [Tetrahedron Lett. 55 (2014) 3706–3708]

Tetrahedron letters, 2015-04, Vol.56 (15), p.2034-2034

2015

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Synthesis, Physicochemical and Pharmacokinetic Studies of Potential Prodrugs of β-L-2′-Deoxycytidine, a Selective and Specific Anti-HBV Agent

Antiviral chemistry & chemotherapy, 2004-10, Vol.15 (5), p.269-279

2004

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Synthesis of unnatural 3′-phospha-2′-deoxyfuranose nucleoside analogues

Tetrahedron letters, 2014-11, Vol.55 (46), p.6328-6330

2014

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Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor

Future medicinal chemistry, 2015-09, Vol.7 (13), p.1675-1700

2015

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Synthesis of unnatural 2- and 3-deoxyfuranose analogues

Tetrahedron letters, 2014-07, Vol.55 (27), p.3706-3708

2014

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Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition statesElectronic supplementary information (ESI) available: Copies of the relevant spectra or analyses (1H NMR, 13C NMR, 31P NMR, MS, HRMS). See DOI: 10.1039/c2ob25131k

2012-05

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Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

Organic & biomolecular chemistry, 2012-05, Vol.10 (17), p.3448-3454

2012

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Synthesis and Anti-HIV Activity of d-peptide Analogs as HIV Fusion Inhibitors

Antiviral research, 2011-05, Vol.90 (2), p.A28-A29

2011

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Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

Antimicrobial Agents and Chemotherapy, 2000-04, Vol.44 (4), p.853-858

2000

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Synthesis and antiviral evaluation of thieno[3,4- d]pyrimidine C-nucleoside analogues of 2′,3′-dideoxy- and 2′,3′-dideoxy-2′,3′-didehydro-adenosine and -inosine

Bioorganic & medicinal chemistry, 2009-03, Vol.17 (6), p.2321-2326

2009

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NM 283, AN EFFICIENT PRODRUG OF THE POTENT ANTI-HCV AGENT 2′-C-METHYLCYTIDINE

Nucleosides, nucleotides & nucleic acids, 2005-01, Vol.24 (5-7), p.767-770

2005

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Synthesis and antiviral evaluation of the 2′-C-methyl branched derivative of a nucleoside analog inhibitor of RNA viral infections, T-1106

Collection of Czechoslovak chemical communications, 2011-01, Vol.76 (11), p.1327-1333

2011

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Synthesis and Antiviral Activity of Oxaselenolane Nucleosides

Journal of medicinal chemistry, 2000-10, Vol.43 (21), p.3906-3912

2000

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Enzymatic synthesis of unlabeled and beta-(32)P-labeled beta-L-2', 3'-dideoxyadenosine-5'-triphosphate as a potent inhibitor of adenylyl cyclases and its use as reversible binding ligand

The Journal of biological chemistry, 1999-12, Vol.274 (49), p.34735

1999

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Synthesis of 2'-C-Methylcytidine and 2'-C-Methyluridine Derivatives Modified in the 3'-Position as Potential Antiviral Agents

Collection of Czechoslovak chemical communications, 2006-01, Vol.71 (7), p.991-1010

2006

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Enzymatic Properties of the Unnatural β-l-Enantiomers of 2‘,3‘-Dideoxyadenosine and 2‘,3‘-Didehydro-2‘,3‘-dideoxyadenosine

Journal of medicinal chemistry, 1997-11, Vol.40 (24), p.3969-3973

1997

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HBV replication inhibitors

The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2′-α-chloro-2′-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors

Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase

Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

2′-C-Methyl Branched Pyrimidine Ribonucleoside Analogues: Potent Inhibitors of RNA Virus Replication

Synthesis and Pharmacokinetics of Valopicitabine (NM283), an Efficient Prodrug of the Potent Anti-HCV Agent 2‘-C-Methylcytidine

Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor

Corrigendum to “Synthesis of unnatural 3′-phospha-2′-deoxyfuranose nucleoside analogues” [Tetrahedron Lett. 55 (2014) 6328–6330]

Synthesis of Unnatural Phosphonosugar Analogues

Corrigendum to “Synthesis of unnatural 2- and 3-deoxyfuranose analogues” [Tetrahedron Lett. 55 (2014) 3706–3708]

Synthesis, Physicochemical and Pharmacokinetic Studies of Potential Prodrugs of β-L-2′-Deoxycytidine, a Selective and Specific Anti-HBV Agent

Synthesis of unnatural 3′-phospha-2′-deoxyfuranose nucleoside analogues

Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor

Synthesis of unnatural 2- and 3-deoxyfuranose analogues

Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition statesElectronic supplementary information (ESI) available: Copies of the relevant spectra or analyses (1H NMR, 13C NMR, 31P NMR, MS, HRMS). See DOI: 10.1039/c2ob25131k

Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states

Synthesis and Anti-HIV Activity of d-peptide Analogs as HIV Fusion Inhibitors

Intracellular Metabolism of β-l-2′,3′-Dideoxyadenosine: Relevance to Its Limited Antiviral Activity

Synthesis and antiviral evaluation of thieno[3,4- d]pyrimidine C-nucleoside analogues of 2′,3′-dideoxy- and 2′,3′-dideoxy-2′,3′-didehydro-adenosine and -inosine

NM 283, AN EFFICIENT PRODRUG OF THE POTENT ANTI-HCV AGENT 2′-C-METHYLCYTIDINE

Synthesis and antiviral evaluation of the 2′-C-methyl branched derivative of a nucleoside analog inhibitor of RNA viral infections, T-1106

Synthesis and Antiviral Activity of Oxaselenolane Nucleosides

Enzymatic synthesis of unlabeled and beta-(32)P-labeled beta-L-2', 3'-dideoxyadenosine-5'-triphosphate as a potent inhibitor of adenylyl cyclases and its use as reversible binding ligand

Synthesis of 2'-C-Methylcytidine and 2'-C-Methyluridine Derivatives Modified in the 3'-Position as Potential Antiviral Agents

Enzymatic Properties of the Unnatural β-l-Enantiomers of 2‘,3‘-Dideoxyadenosine and 2‘,3‘-Didehydro-2‘,3‘-dideoxyadenosine

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