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Evaluating the chaos game representation of proteins for applications in machine learning models: prediction of antibody affinity and specificity as a case study

Journal of molecular modeling, 2023-12, Vol.29 (12), p.377-377, Article 377

2023

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Is Lyophilization Key for Transportation and Storage of Biopharmaceutical Drug Products in Space?

Journal of pharmaceutical sciences, 2024-07, Vol.113 (7), p.1695-1700

Menzen, Tim

2024

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Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties

mAbs, 2023-12, Vol.15 (1), p.2164459-2164459

2023

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Prediction of Unwanted Crystallization of Freeze-Dried Protein Formulations Using α-Relaxation Measurements

Pharmaceutics, 2023-02, Vol.15 (2), p.703

2023

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Oil-Immersion Flow Imaging Microscopy for Quantification and Morphological Characterization of Submicron Particles in Biopharmaceuticals

The AAPS journal, 2021-01, Vol.23 (1), p.13-13, Article 13

2021

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Minimizing Oxidation of Freeze-Dried Monoclonal Antibodies in Polymeric Vials Using a Smart Packaging Approach

Pharmaceutics, 2021-10, Vol.13 (10), p.1695

2021

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Calorimetric Investigation of the Relaxation Phenomena in Amorphous Lyophilized Solids

Pharmaceutics, 2021-10, Vol.13 (10), p.1735

2021

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Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors

Pharmaceutics, 2021-05, Vol.13 (5), p.748

2021

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Genome length determination in adeno-associated virus vectors with mass photometry

Molecular therapy. Methods & clinical development, 2023-12, Vol.31, p.101162-101162, Article 101162

2023

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A model-based optimization strategy to achieve fast and robust freeze-drying cycles

International journal of pharmaceutics: X, 2023-12, Vol.5, p.100180-100180, Article 100180

2023

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High-Throughput Melting-Temperature Analysis of a Monoclonal Antibody by Differential Scanning Fluorimetry in the Presence of Surfactants

Journal of pharmaceutical sciences, 2013-02, Vol.102 (2), p.415-428

2013

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Temperature-Ramped Studies on the Aggregation, Unfolding, and Interaction of a Therapeutic Monoclonal Antibody

Journal of pharmaceutical sciences, 2014-02, Vol.103 (2), p.445-455

2014

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Systematic Studies on Stabilization of AAV Vector Formulations by Lyophilization

Journal of pharmaceutical sciences, 2022-08, Vol.111 (8), p.2288-2298

2022

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Possibilities and limitations of α-relaxation data of amorphous freeze-dried cakes to predict long term IgG1 antibody stability

International journal of pharmaceutics, 2023-11, Vol.646, p.123445-123445, Article 123445

2023

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Exploring Chemical Space for New Substances to Stabilize a Therapeutic Monoclonal Antibody

Journal of pharmaceutical sciences, 2020-01, Vol.109 (1), p.301-307

2020

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Micelle Driven Oxidation Mechansim and Novel Oxidation Markers for Different Grades of Polysorbate 20 and 80

Journal of pharmaceutical sciences, 2020-10, Vol.109 (10), p.3064-3077

2020

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Towards quantification and differentiation of protein aggregates and silicone oil droplets in the low micrometer and submicrometer size range by using oil-immersion flow imaging microscopy and convolutional neural networks

European journal of pharmaceutics and biopharmaceutics, 2021-12, Vol.169, p.97-102

2021

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SV-AUC as a stability-indicating method for the characterization of mRNA-LNPs

European journal of pharmaceutics and biopharmaceutics, 2023-01, Vol.182, p.152-156

2023

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Challenges in the analysis of pharmaceutical lentiviral vector products by orthogonal and complementary physical (nano)particle characterization techniques

European journal of pharmaceutics and biopharmaceutics, 2024-07, Vol.200, p.114340, Article 114340

2024

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Utility of Three Flow Imaging Microscopy Instruments for Image Analysis in Evaluating four Types of Subvisible Particle in Biopharmaceuticals

Journal of pharmaceutical sciences, 2022-11, Vol.111 (11), p.3017-3028

2022

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Backgrounded Membrane Imaging (BMI) for High-Throughput Characterization of Subvisible Particles During Biopharmaceutical Drug Product Development

Journal of pharmaceutical sciences, 2020-01, Vol.109 (1), p.264-276

2020

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What Makes Polysorbate Functional? Impact of Polysorbate 80 Grade and Quality on IgG Stability During Mechanical Stress

Journal of pharmaceutical sciences, 2020-01, Vol.109 (1), p.871-880

2020

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Ongoing Challenges to Develop High Concentration Monoclonal Antibody-based Formulations for Subcutaneous Administration: Quo Vadis?

Journal of pharmaceutical sciences, 2022-04, Vol.111 (4), p.861-867

2022

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Particles in Biopharmaceutical Formulations, Part 2: An Update on Analytical Techniques and Applications for Therapeutic Proteins, Viruses, Vaccines and Cells

Journal of pharmaceutical sciences, 2022-04, Vol.111 (4), p.933-950

2022

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Comparison of Submicron Particle Counting Methods with a Heat Stressed Monoclonal Antibody: Effect of Electrolytes and Implications on Sample Preparation

Journal of pharmaceutical sciences, 2022-07, Vol.111 (7), p.1992-1999

2022

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Evaluating the chaos game representation of proteins for applications in machine learning models: prediction of antibody affinity and specificity as a case study

Is Lyophilization Key for Transportation and Storage of Biopharmaceutical Drug Products in Space?

Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties

Prediction of Unwanted Crystallization of Freeze-Dried Protein Formulations Using α-Relaxation Measurements

Oil-Immersion Flow Imaging Microscopy for Quantification and Morphological Characterization of Submicron Particles in Biopharmaceuticals

Minimizing Oxidation of Freeze-Dried Monoclonal Antibodies in Polymeric Vials Using a Smart Packaging Approach

Calorimetric Investigation of the Relaxation Phenomena in Amorphous Lyophilized Solids

Comparison of Different Liquid Chromatography-Based Purification Strategies for Adeno-Associated Virus Vectors

Genome length determination in adeno-associated virus vectors with mass photometry

A model-based optimization strategy to achieve fast and robust freeze-drying cycles

High-Throughput Melting-Temperature Analysis of a Monoclonal Antibody by Differential Scanning Fluorimetry in the Presence of Surfactants

Temperature-Ramped Studies on the Aggregation, Unfolding, and Interaction of a Therapeutic Monoclonal Antibody

Systematic Studies on Stabilization of AAV Vector Formulations by Lyophilization

Possibilities and limitations of α-relaxation data of amorphous freeze-dried cakes to predict long term IgG1 antibody stability

Exploring Chemical Space for New Substances to Stabilize a Therapeutic Monoclonal Antibody

Micelle Driven Oxidation Mechansim and Novel Oxidation Markers for Different Grades of Polysorbate 20 and 80

Towards quantification and differentiation of protein aggregates and silicone oil droplets in the low micrometer and submicrometer size range by using oil-immersion flow imaging microscopy and convolutional neural networks

SV-AUC as a stability-indicating method for the characterization of mRNA-LNPs

Challenges in the analysis of pharmaceutical lentiviral vector products by orthogonal and complementary physical (nano)particle characterization techniques

Utility of Three Flow Imaging Microscopy Instruments for Image Analysis in Evaluating four Types of Subvisible Particle in Biopharmaceuticals

Backgrounded Membrane Imaging (BMI) for High-Throughput Characterization of Subvisible Particles During Biopharmaceutical Drug Product Development

What Makes Polysorbate Functional? Impact of Polysorbate 80 Grade and Quality on IgG Stability During Mechanical Stress

Ongoing Challenges to Develop High Concentration Monoclonal Antibody-based Formulations for Subcutaneous Administration: Quo Vadis?

Particles in Biopharmaceutical Formulations, Part 2: An Update on Analytical Techniques and Applications for Therapeutic Proteins, Viruses, Vaccines and Cells

Comparison of Submicron Particle Counting Methods with a Heat Stressed Monoclonal Antibody: Effect of Electrolytes and Implications on Sample Preparation

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