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Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

Advanced drug delivery reviews, 2011-10, Vol.63 (13), p.1118-1159

2011

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Evaluating the Role of the Air-Solution Interface on the Mechanism of Subvisible Particle Formation Caused by Mechanical Agitation for an IgG1 mAb

Journal of pharmaceutical sciences, 2016-05, Vol.105 (5), p.1643-1656

2016

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Vaccine instability in the cold chain: Mechanisms, analysis and formulation strategies

Biologicals, 2014-09, Vol.42 (5), p.237-259

2014

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High-Throughput Biophysical Analysis of Protein Therapeutics to Examine Interrelationships Between Aggregate Formation and Conformational Stability

The AAPS journal, 2014-01, Vol.16 (1), p.48-64

2014

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Effects of Protein Conformation, Apparent Solubility, and Protein–Protein Interactions on the Rates and Mechanisms of Aggregation for an IgG1Monoclonal Antibody

The journal of physical chemistry. B, 2016-07, Vol.120 (29), p.7062-7075

2016

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A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Nature communications, 2023-04, Vol.14 (1), p.2149-2149, Article 2149

2023

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Structural Characterization of IgG1 mAb Aggregates and Particles Generated Under Various Stress Conditions

Journal of pharmaceutical sciences, 2014-03, Vol.103 (3), p.796-809

2014

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Structural Changes and Aggregation Mechanisms of Two Different Dimers of an IgG2 Monoclonal Antibody

Biochemistry (Easton), 2018-09, Vol.57 (37), p.5466-5479

2018

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Effect of solution properties on the counting and sizing of subvisible particle standards as measured by light obscuration and digital imaging methods

European journal of pharmaceutical sciences, 2014-03, Vol.53, p.95-108

2014

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Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity

mAbs, 2016-11, Vol.8 (8), p.1561-1574

2016

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Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication

Human vaccines & immunotherapeutics, 2022-12, Vol.18 (7), p.2154100-2154100

2022

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Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration

Journal of pharmaceutical sciences, 2020-01, Vol.109 (1), p.407-421

2020

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Characterization of Excipient Effects on Reversible Self-Association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 1

Journal of pharmaceutical sciences, 2020-01, Vol.109 (1), p.340-352

2020

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Effects of Salts from the Hofmeister Series on the Conformational Stability, Aggregation Propensity, and Local Flexibility of an IgG1 Monoclonal Antibody

Biochemistry (Easton), 2013-05, Vol.52 (19), p.3376-3389

2013

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Development of a Microflow Digital Imaging Assay to Characterize Protein Particulates During Storage of a High Concentration IgG1 Monoclonal Antibody Formulation

Journal of pharmaceutical sciences, 2010-08, Vol.99 (8), p.3343-3361

2010

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Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Nature communications, 2023-10, Vol.14 (1), p.6211-6211, Article 6211

2023

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Addressing the Cold Reality of mRNA Vaccine Stability

Journal of pharmaceutical sciences, 2021-03, Vol.110 (3), p.997-1001

2021

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Evaluation of Hydrogen Exchange Mass Spectrometry as a Stability-Indicating Method for Formulation Excipient Screening for an IgG4 Monoclonal Antibody

Journal of pharmaceutical sciences, 2018-04, Vol.107 (4), p.1009-1019

2018

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Impact of Glycosylation on the Local Backbone Flexibility of Well-Defined IgG1-Fc Glycoforms Using Hydrogen Exchange-Mass Spectrometry

Journal of pharmaceutical sciences, 2018-09, Vol.107 (9), p.2315-2324

2018

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The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate

Malaria journal, 2019-11, Vol.18 (1), p.356-356, Article 356

2019

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Improved data visualization techniques for analyzing macromolecule structural changes

Protein science, 2012-10, Vol.21 (10), p.1540-1553

2012

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Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life

mAbs, 2015-01, Vol.7 (1), p.84-95

2015

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Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants

Human vaccines & immunotherapeutics, 2022-11, Vol.18 (5), p.2079346-2079346

2022

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Production, Characterization, and Biological Evaluation of Well-Defined IgG1 Fc Glycoforms as a Model System for Biosimilarity Analysis

Journal of pharmaceutical sciences, 2016-02, Vol.105 (2), p.559-574

2016

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Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD)

Human vaccines & immunotherapeutics, 2023-08, Vol.19 (2), p.2264594-2264594

2023

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Protein–excipient interactions: Mechanisms and biophysical characterization applied to protein formulation development

Evaluating the Role of the Air-Solution Interface on the Mechanism of Subvisible Particle Formation Caused by Mechanical Agitation for an IgG1 mAb

Vaccine instability in the cold chain: Mechanisms, analysis and formulation strategies

High-Throughput Biophysical Analysis of Protein Therapeutics to Examine Interrelationships Between Aggregate Formation and Conformational Stability

Effects of Protein Conformation, Apparent Solubility, and Protein–Protein Interactions on the Rates and Mechanisms of Aggregation for an IgG1Monoclonal Antibody

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Structural Characterization of IgG1 mAb Aggregates and Particles Generated Under Various Stress Conditions

Structural Changes and Aggregation Mechanisms of Two Different Dimers of an IgG2 Monoclonal Antibody

Effect of solution properties on the counting and sizing of subvisible particle standards as measured by light obscuration and digital imaging methods

Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity

Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication

Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration

Characterization of Excipient Effects on Reversible Self-Association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 1

Effects of Salts from the Hofmeister Series on the Conformational Stability, Aggregation Propensity, and Local Flexibility of an IgG1 Monoclonal Antibody

Development of a Microflow Digital Imaging Assay to Characterize Protein Particulates During Storage of a High Concentration IgG1 Monoclonal Antibody Formulation

Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

Addressing the Cold Reality of mRNA Vaccine Stability

Evaluation of Hydrogen Exchange Mass Spectrometry as a Stability-Indicating Method for Formulation Excipient Screening for an IgG4 Monoclonal Antibody

Impact of Glycosylation on the Local Backbone Flexibility of Well-Defined IgG1-Fc Glycoforms Using Hydrogen Exchange-Mass Spectrometry

The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate

Improved data visualization techniques for analyzing macromolecule structural changes

Correlations between changes in conformational dynamics and physical stability in a mutant IgG1 mAb engineered for extended serum half-life

Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants

Production, Characterization, and Biological Evaluation of Well-Defined IgG1 Fc Glycoforms as a Model System for Biosimilarity Analysis

Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD)

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