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Endogenous µ‐opioid receptor activity in the lateral and capsular subdivisions of the right central nucleus of the amygdala prevents chronic postoperative pain

Journal of neuroscience research, 2022-01, Vol.100 (1), p.48-65

2022

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Cerebrolysin improves peripheral inflammatory pain: Sex differences in two models of acute and chronic mechanical hypersensitivity

Drug development research, 2019-06, Vol.80 (4), p.513-518

2019

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EPD1504: a novel μ-opioid receptor partial agonist attenuates obsessive-compulsive disorder (OCD)-like behaviors

Frontiers in psychiatry, 2023-06, Vol.14, p.1170541-1170541

2023

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Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer

Cancer research (Chicago, Ill.), 2006-08, Vol.66 (15), p.7701-7707

2006

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Gene Expression Analysis of Host Innate Immune Responses during Lethal H5N1 Infection in Ferrets

Journal of Virology, 2008-11, Vol.82 (22), p.11308-11317

2008

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Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii in the Intensive Care Unit of Uruguay's University Hospital Identifies the First rmtC Gene in the Species

Microbial drug resistance (Larchmont, N.Y.), 2018-09, Vol.24 (7), p.1012

2018

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Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs

International journal of cancer, 2009-12, Vol.125 (11), p.2586-2594

2009

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Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (18), p.5942-5947

2012

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Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles

ACS medicinal chemistry letters, 2013-06, Vol.4 (6), p.551-555

2013

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A Novel Maintenance Therapeutic for Opioid Use Disorder

The Journal of pharmacology and experimental therapeutics, 2021-08, Vol.378 (2), p.133

2021

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Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

Journal of medicinal chemistry, 2014-02, Vol.57 (4), p.1454-1472

2014

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Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications

Bioorganic & medicinal chemistry letters, 2023-08, Vol.92, p.129405, Article 129405

2023

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An inhibitory metabolite leads to dose- and time-dependent pharmacokinetics of (R)-N-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in human subjects after multiple dosing

Drug metabolism and disposition, 2009-03, Vol.37 (3), p.502

2009

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Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101)

Journal of medicinal chemistry, 2018-09, Vol.61 (17), p.7767-7784

2018

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Selective, Covalent Modification of β -Tubulin Residue Cys-239 by T138067, an Antitumor Agent with in vivo Efficacy against Multidrug-Resistant Tumors

Proceedings of the National Academy of Sciences - PNAS, 1999-05, Vol.96 (10), p.5686-5691

1999

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Discovery and in Vivo Evaluation of Macrocyclic Mcl‑1 Inhibitors Featuring an α‑Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere

Journal of medicinal chemistry, 2019-11, Vol.62 (22), p.10258-10271

2019

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Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease

Journal of medicinal chemistry, 2015-01, Vol.58 (1), p.480-511

2015

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AMG 837: A potent, orally bioavailable GPR40 agonist

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1267-1270

2012

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Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.4936-4954

2012

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An Expeditious Synthesis of the MDM2–p53 Inhibitor AM-8553

Journal of the American Chemical Society, 2012-08, Vol.134 (30), p.12855-12860

2012

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Online continuing interprofessional education on hospital-acquired infections for Latin America

The Brazilian journal of infectious diseases, 2017-03, Vol.21 (2), p.140-147

2017

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Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2472-2488

2014

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Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors

Journal of medicinal chemistry, 2016-01, Vol.59 (1), p.431-447

2016

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Role of LXRs in control of lipogenesis

Genes & development, 2000-11, Vol.14 (22), p.2831-2838

2000

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Discovery of AMG 853, a CRTH2 and DP Dual Antagonist

ACS medicinal chemistry letters, 2011-05, Vol.2 (5), p.326-330

2011

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Endogenous µ‐opioid receptor activity in the lateral and capsular subdivisions of the right central nucleus of the amygdala prevents chronic postoperative pain

Cerebrolysin improves peripheral inflammatory pain: Sex differences in two models of acute and chronic mechanical hypersensitivity

EPD1504: a novel μ-opioid receptor partial agonist attenuates obsessive-compulsive disorder (OCD)-like behaviors

Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer

Gene Expression Analysis of Host Innate Immune Responses during Lethal H5N1 Infection in Ferrets

Molecular Characterization of Carbapenem-Resistant Acinetobacter baumannii in the Intensive Care Unit of Uruguay's University Hospital Identifies the First rmtC Gene in the Species

Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs

Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus

Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles

A Novel Maintenance Therapeutic for Opioid Use Disorder

Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development

Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications

An inhibitory metabolite leads to dose- and time-dependent pharmacokinetics of (R)-N-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in human subjects after multiple dosing

Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101)

Selective, Covalent Modification of β -Tubulin Residue Cys-239 by T138067, an Antitumor Agent with in vivo Efficacy against Multidrug-Resistant Tumors

Discovery and in Vivo Evaluation of Macrocyclic Mcl‑1 Inhibitors Featuring an α‑Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere

Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease

AMG 837: A potent, orally bioavailable GPR40 agonist

Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction

An Expeditious Synthesis of the MDM2–p53 Inhibitor AM-8553

Online continuing interprofessional education on hospital-acquired infections for Latin America

Selective and Potent Morpholinone Inhibitors of the MDM2–p53 Protein–Protein Interaction

Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors

Role of LXRs in control of lipogenesis

Discovery of AMG 853, a CRTH2 and DP Dual Antagonist

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