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The host STING pathway at the interface of cancer and immunity

The Journal of clinical investigation, 2016-07, Vol.126 (7), p.2404-2411

2016

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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

Cell reports (Cambridge), 2015-05, Vol.11 (7), p.1018-1030

2015

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SLC19A1 transports immunoreactive cyclic dinucleotides

Nature (London), 2019-09, Vol.573 (7774), p.434-438

2019

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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

Science translational medicine, 2015-04, Vol.7 (283), p.283ra52

2015

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Combination of the STING Agonist MIW815 (ADU-S100) and PD-1 Inhibitor Spartalizumab in Advanced/Metastatic Solid Tumors or Lymphomas: An Open-Label, Multicenter, Phase Ib Study

Clinical cancer research, 2023-01, Vol.29 (1), p.110-121

2023

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Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila

PLoS pathogens, 2009-11, Vol.5 (11), p.e1000665-e1000665

2009

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Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA

The Journal of immunology (1950), 2016-04, Vol.196 (7), p.3191-3198

2016

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IFN-Regulatory Factor 3-Dependent Gene Expression Is Defective in Tbk1-Deficient Mouse Embryonic Fibroblasts

Proceedings of the National Academy of Sciences - PNAS, 2004-01, Vol.101 (1), p.233-238

2004

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Induction of type I interferons by bacteria

Cellular microbiology, 2010-07, Vol.12 (7), p.881-890

2010

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Circulating tumor cells in hepatocellular carcinoma: a pilot study of detection, enumeration, and next-generation sequencing in cases and controls

BMC cancer, 2015-03, Vol.15 (1), p.206-206, Article 206

2015

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STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection

Cell reports (Cambridge), 2018-05, Vol.23 (5), p.1435-1447

2018

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A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

The Journal of experimental medicine, 2009-08, Vol.206 (9), p.1899-1911

2009

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Caenorhabditis elegans ETR-1/CELF has broad effects on the muscle cell transcriptome, including genes that regulate translation and neuroblast migration

BMC genomics, 2022-01, Vol.23 (1), p.13-13, Article 13

2022

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Modulation of Kinase Activities In Vitro by Hepatitis C Virus Protease NS3/NS4A Mediated-Cleavage of Key Immune Modulator Kinases

Cells (Basel, Switzerland), 2023-01, Vol.12 (3), p.406

2023

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Interferon Regulatory Factor 3 Is Regulated by a Dual Phosphorylation-dependent Switch

The Journal of biological chemistry, 2007-08, Vol.282 (31), p.22816-22822

2007

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Nucleic Acid Sensors as Therapeutic Targets for Human Disease

Immunity (Cambridge, Mass.), 2020-07, Vol.53 (1), p.78-97

2020

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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

Cell reports (Cambridge), 2018-12, Vol.25 (11), p.3074-3085.e5

2018

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IKKε and TBK1 are essential components of the IRF3 signaling pathway

Nature immunology, 2003-05, Vol.4 (5), p.491-496

2003

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MK5 activates Rag transcription via Foxo1 in developing B cells

The Journal of experimental medicine, 2013-07, Vol.210 (8), p.1621-1634

2013

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Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas

Clinical cancer research, 2022-02, Vol.28 (4), p.677-688

2022

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Crystallographic Analysis of CD40 Recognition and Signaling by Human TRAF2

Proceedings of the National Academy of Sciences - PNAS, 1999-07, Vol.96 (15), p.8408-8413

1999

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Gfi1 and gfi1b repress rag transcription in plasmacytoid dendritic cells in vitro

PloS one, 2013-09, Vol.8 (9), p.e75891-e75891

2013

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NK cells mediate clearance of CD8 + T cell-resistant tumors in response to STING agonists

Science immunology, 2020-03, Vol.5 (45)

2020

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Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1

The Journal of experimental medicine, 2012-01, Vol.209 (1), p.187-199

2012

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Connecting Mitochondria and Innate Immunity

Cell, 2005-09, Vol.122 (5), p.645-647

2005

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The host STING pathway at the interface of cancer and immunity

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

SLC19A1 transports immunoreactive cyclic dinucleotides

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

Combination of the STING Agonist MIW815 (ADU-S100) and PD-1 Inhibitor Spartalizumab in Advanced/Metastatic Solid Tumors or Lymphomas: An Open-Label, Multicenter, Phase Ib Study

Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila

Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA

IFN-Regulatory Factor 3-Dependent Gene Expression Is Defective in Tbk1-Deficient Mouse Embryonic Fibroblasts

Induction of type I interferons by bacteria

Circulating tumor cells in hepatocellular carcinoma: a pilot study of detection, enumeration, and next-generation sequencing in cases and controls

STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

Caenorhabditis elegans ETR-1/CELF has broad effects on the muscle cell transcriptome, including genes that regulate translation and neuroblast migration

Modulation of Kinase Activities In Vitro by Hepatitis C Virus Protease NS3/NS4A Mediated-Cleavage of Key Immune Modulator Kinases

Interferon Regulatory Factor 3 Is Regulated by a Dual Phosphorylation-dependent Switch

Nucleic Acid Sensors as Therapeutic Targets for Human Disease

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

IKKε and TBK1 are essential components of the IRF3 signaling pathway

MK5 activates Rag transcription via Foxo1 in developing B cells

Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas

Crystallographic Analysis of CD40 Recognition and Signaling by Human TRAF2

Gfi1 and gfi1b repress rag transcription in plasmacytoid dendritic cells in vitro

NK cells mediate clearance of CD8 + T cell-resistant tumors in response to STING agonists

Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1

Connecting Mitochondria and Innate Immunity

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