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A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.453-461

2018

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Systematic Study of the Glutathione Reactivity of N‑Phenylacrylamides: 2. Effects of Acrylamide Substitution

Journal of medicinal chemistry, 2020-10, Vol.63 (20), p.11602-11614

2020

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Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures

Biotechnology and bioengineering, 2015-01, Vol.112 (1), p.141-155

2015

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Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors

Biochimica et biophysica acta, 2011-12, Vol.1814 (12), p.1947-1954

2011

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Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors

Journal of medicinal chemistry, 2011-03, Vol.54 (6), p.1789-1811

2011

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The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Nature (London), 2019-11, Vol.575 (7781), p.217-223

2019

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Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.5188-5219

2012

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The Role of Sugar Substituents in Glycoside Hydrolysis

Journal of the American Chemical Society, 2000-02, Vol.122 (7), p.1270-1277

2000

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IgG1 Thioether Bond Formation in Vivo

The Journal of biological chemistry, 2013-06, Vol.288 (23), p.16371-16382

2013

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Substrate Specificity of the Escherichia coli Outer Membrane Protease OmpT

Journal of Bacteriology, 2004-09, Vol.186 (17), p.5919-5925

2004

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Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe

Journal of medicinal chemistry, 2022-03, Vol.65 (6), p.4972-4990

2022

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Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease

Journal of medicinal chemistry, 2015-01, Vol.58 (1), p.480-511

2015

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Assessment of the integrity of compounds stored in assay-ready plates using a kinase sentinel assay

Combinatorial chemistry & high throughput screening, 2013-09, Vol.16 (8), p.644-651

2013

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Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase

ACS chemical biology, 2016-10, Vol.11 (10), p.2734-2743

2016

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Development of a High-Throughput Affinity Mass Spectrometry (AMS) Platform Using Laser Diode Thermal Desorption Ionization Coupled to Mass Spectrometry (LDTD-MS)

SLAS discovery, 2021-02, Vol.26 (2), p.230-241

2021

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High-Throughput Mass Spectrometric Analysis of Covalent Protein-Inhibitor Adducts for the Discovery of Irreversible Inhibitors: A Complete Workflow

Journal of biomolecular screening, 2016-02, Vol.21 (2), p.136-144

2016

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High-throughput assays for sirtuin enzymes: A microfluidic mobility shift assay and a bioluminescence assay

Analytical biochemistry, 2008-07, Vol.378 (1), p.53-59

2008

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Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.52-65

2020

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Discovery of a Covalent Inhibitor of KRAS G12C (AMG 510) for the Treatment of Solid Tumors

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.52-65

2020

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A Structural View of the Action of Escherichia coli (lacZ) β-Galactosidase

Biochemistry (Easton), 2001-12, Vol.40 (49), p.14781-14794

2001

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Mechanisms of enzymatic glycoside hydrolysis

Current opinion in structural biology, 1994, Vol.4 (6), p.885-892

1994

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Structural, Mechanistic, and Computational Analysis of the Effects of Anomeric Fluorines on Anomeric Fluoride Departure in 5-Fluoroxylosyl Fluorides

Journal of the American Chemical Society, 2011-10, Vol.133 (40), p.15826-15829

2011

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Synthesis and Testing of 2-Deoxy-2,2-Dihaloglycosides as Mechanism-Based Inhibitors of α-Glycosidases

Journal of organic chemistry, 2008-04, Vol.73 (8), p.3070-3077

2008

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A “Click Chemistry Platform” for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation

Systematic Study of the Glutathione Reactivity of N‑Phenylacrylamides: 2. Effects of Acrylamide Substitution

Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures

Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors

Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

The Role of Sugar Substituents in Glycoside Hydrolysis

IgG1 Thioether Bond Formation in Vivo

Substrate Specificity of the Escherichia coli Outer Membrane Protease OmpT

Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe

Discovery and in Vivo Evaluation of (S)‑N‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9H‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease

Assessment of the integrity of compounds stored in assay-ready plates using a kinase sentinel assay

Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase

Development of a High-Throughput Affinity Mass Spectrometry (AMS) Platform Using Laser Diode Thermal Desorption Ionization Coupled to Mass Spectrometry (LDTD-MS)

High-Throughput Mass Spectrometric Analysis of Covalent Protein-Inhibitor Adducts for the Discovery of Irreversible Inhibitors: A Complete Workflow

High-throughput assays for sirtuin enzymes: A microfluidic mobility shift assay and a bioluminescence assay

Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

Discovery of a Covalent Inhibitor of KRAS G12C (AMG 510) for the Treatment of Solid Tumors

A Structural View of the Action of Escherichia coli (lacZ) β-Galactosidase

Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers

Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

Mechanisms of enzymatic glycoside hydrolysis

Structural, Mechanistic, and Computational Analysis of the Effects of Anomeric Fluorines on Anomeric Fluoride Departure in 5-Fluoroxylosyl Fluorides

Synthesis and Testing of 2-Deoxy-2,2-Dihaloglycosides as Mechanism-Based Inhibitors of α-Glycosidases

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