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Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity

European journal of medicinal chemistry, 2017-09, Vol.138, p.128-139

2017

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A 1,8-Naphthyridone Derivative Targets the HIV-1 Tat-Mediated Transcription and Potently Inhibits the HIV-1 Replication

Journal of medicinal chemistry, 2010-01, Vol.53 (2), p.641-648

2010

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1,2,4-Triazolo[1,5- a ]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

Molecules (Basel, Switzerland), 2020-03, Vol.25 (5), p.1183

2020

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Blocking HIV-1 replication by targeting the Tat-hijacked transcriptional machinery

Current pharmaceutical design, 2013-03, Vol.19 (10), p.1860

2013

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Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives

Organic & biomolecular chemistry, 2017, Vol.15 (37), p.7944-7955

2017

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Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells

Frontiers in immunology, 2019-08, Vol.10, p.1973-1973

2019

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Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors

International journal of molecular sciences, 2020-10, Vol.21 (19), p.7037

2020

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Structural Investigation of Cycloheptathiophene-3-carboxamide Derivatives Targeting Influenza Virus Polymerase Assembly

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10118-10131

2013

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From small to powerful: the fragments universe and its "chem-appeal"

Current medicinal chemistry, 2013-04, Vol.20 (11), p.1355

2013

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C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2020-01, Vol.35 (1), p.584-597

2020

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From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2019-01, Vol.34 (1), p.55-74

2019

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From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia

Pharmaceutics, 2022-10, Vol.14 (11), p.2295

2022

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Reducing Mutant Huntingtin Protein Expression in Living Cells by a Newly Identified RNA CAG Binder

ACS chemical neuroscience, 2018-06, Vol.9 (6), p.1399-1408

2018

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Structure−Activity Relationship Study on Anti-HIV 6-Desfluoroquinolones

Journal of medicinal chemistry, 2008-09, Vol.51 (17), p.5454-5458

2008

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Protein–protein interactions by influenza polymerase subunits as drug targets

Future medicinal chemistry, 2022-01, Vol.14 (2), p.53-56

2022

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The 6-Aminoquinolone WC5 Inhibits Human Cytomegalovirus Replication at an Early Stage by Interfering with the Transactivating Activity of Viral Immediate-Early 2 Protein

Antimicrobial Agents and Chemotherapy, 2010-05, Vol.54 (5), p.1930-1940

2010

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Polymerase Acidic Protein–Basic Protein 1 (PA–PB1) Protein–Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7699-7718

2016

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Small Molecules Targeting DNA Polymerase Theta (POLθ) as Promising Synthetic Lethal Agents for Precision Cancer Therapy

Journal of medicinal chemistry, 2023-05, Vol.66 (10), p.6498-6522

2023

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Q‑raKtion: A Semiautomated KNIME Workflow for Bioactivity Data Points Curation

Journal of chemical information and modeling, 2022-12, Vol.62 (24), p.6309-6315

2022

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Triazolopyrimidine Nuclei: Privileged Scaffolds for Developing Antiviral Agents with a Proper Pharmacokinetic Profile

Current medicinal chemistry, 2022-03, Vol.29 (8), p.1379

2022

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Synergistic activity of an RNA polymerase PA-PB1 interaction inhibitor with oseltamivir against human and avian influenza viruses in cell culture and in ovo

Antiviral research, 2024-08, p.105980, Article 105980

2024

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2‐Phenylquinolones as Inhibitors of the HIV‐1 Tat–TAR Interaction

ChemMedChem, 2009-06, Vol.4 (6), p.935-938

2009

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A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.3830-3842

2015

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Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance

Antiviral research, 2019-05, Vol.165, p.55-64

2019

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1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors

European journal of medicinal chemistry, 2021-10, Vol.221, p.113494-113494, Article 113494

2021

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Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity

A 1,8-Naphthyridone Derivative Targets the HIV-1 Tat-Mediated Transcription and Potently Inhibits the HIV-1 Replication

1,2,4-Triazolo[1,5- a ]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

Blocking HIV-1 replication by targeting the Tat-hijacked transcriptional machinery

Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives

Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells

Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors

Structural Investigation of Cycloheptathiophene-3-carboxamide Derivatives Targeting Influenza Virus Polymerase Assembly

From small to powerful: the fragments universe and its "chem-appeal"

C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors

From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia

Reducing Mutant Huntingtin Protein Expression in Living Cells by a Newly Identified RNA CAG Binder

Structure−Activity Relationship Study on Anti-HIV 6-Desfluoroquinolones

Protein–protein interactions by influenza polymerase subunits as drug targets

The 6-Aminoquinolone WC5 Inhibits Human Cytomegalovirus Replication at an Early Stage by Interfering with the Transactivating Activity of Viral Immediate-Early 2 Protein

Polymerase Acidic Protein–Basic Protein 1 (PA–PB1) Protein–Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics

Small Molecules Targeting DNA Polymerase Theta (POLθ) as Promising Synthetic Lethal Agents for Precision Cancer Therapy

Q‑raKtion: A Semiautomated KNIME Workflow for Bioactivity Data Points Curation

Triazolopyrimidine Nuclei: Privileged Scaffolds for Developing Antiviral Agents with a Proper Pharmacokinetic Profile

Synergistic activity of an RNA polymerase PA-PB1 interaction inhibitor with oseltamivir against human and avian influenza viruses in cell culture and in ovo

2‐Phenylquinolones as Inhibitors of the HIV‐1 Tat–TAR Interaction

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits

Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance

1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors

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