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Drug Repurposing for Viral Infectious Diseases: How Far Are We?

Trends in microbiology (Regular ed.), 2018-10, Vol.26 (10), p.865-876

2018

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Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase

Proceedings of the National Academy of Sciences - PNAS, 2012-04, Vol.109 (16), p.6247-6252

2012

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HPV16 E6 and E7 upregulate the histone lysine demethylase KDM2B through the c-MYC/miR-146a-5p axys

Oncogene, 2018-03, Vol.37 (12), p.1654-1668

2018

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Targeted Disruption of E6/p53 Binding Exerts Broad Activity and Synergism with Paclitaxel and Topotecan against HPV-Transformed Cancer Cells

Cancers, 2021-12, Vol.14 (1), p.193

2021

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Discovery of Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant

Molecules (Basel, Switzerland), 2022-09, Vol.27 (19), p.6426

2022

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Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity

European journal of medicinal chemistry, 2017-09, Vol.138, p.128-139

2017

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Discovery of highly potent and selective influenza virus neuraminidase inhibitors targeting 150-cavity

European journal of medicinal chemistry, 2021-02, Vol.212, p.113097, Article 113097

2021

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Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives

Organic & biomolecular chemistry, 2017, Vol.15 (37), p.7944-7955

2017

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A novel N -heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation

Journal of enzyme inhibition and medicinal chemistry, 2023-12, Vol.38 (1), p.2277135-2277135

2023

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The Dimeric Form of HPV16 E6 Is Crucial to Drive YAP/TAZ Upregulation through the Targeting of hScrib

Cancers, 2021-08, Vol.13 (16), p.4083

2021

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Structural Investigation of Cycloheptathiophene-3-carboxamide Derivatives Targeting Influenza Virus Polymerase Assembly

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10118-10131

2013

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Contemporary medicinal chemistry strategies for the discovery and optimization of influenza inhibitors targeting vRNP constituent proteins

Acta pharmaceutica Sinica. B, 2022-04, Vol.12 (4), p.1805-1824

2022

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Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy In Vivo

mBio, 2023-02, Vol.14 (1), p.e0309722-e0309722

2023

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Divide et impera: An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication

Viruses, 2021-05, Vol.13 (5), p.941

2021

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Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses

Antimicrobial Agents and Chemotherapy, 2012-11, Vol.56 (11), p.6009-6013

2012

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A point mutation in a herpesvirus polymerase determines neuropathogenicity

PLoS pathogens, 2007-11, Vol.3 (11), p.e160-e160

2007

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Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on "The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts"

Viruses, 2019-01, Vol.11 (2), p.117

2019

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HPV-induced cancers: preclinical therapeutic advancements

Expert opinion on investigational drugs, 2022-01, Vol.31 (1), p.79-93

2022

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Human cytomegalovirus DNA replication: antiviral targets and drugs

Reviews in medical virology, 2008-05, Vol.18 (3), p.177-210

2008

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The human cytomegalovirus DNA polymerase processivity factor UL44 is modified by SUMO in a DNA-dependent manner

PloS one, 2012-11, Vol.7 (11), p.e49630-e49630

2012

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Daclatasvir plasma level and resistance selection in HIV patients with hepatitis C virus cirrhosis treated with daclatasvir, sofosbuvir, and ribavirin

International journal of infectious diseases, 2016-08, Vol.49 (C), p.151-153

2016

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Analysis of the Association of the Human Cytomegalovirus DNA Polymerase Subunit UL44 with the Viral DNA Replication Factor UL84

Journal of Virology, 2009-08, Vol.83 (15), p.7581-7589

2009

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Sulfated Derivatives of Escherichia coli K5 Capsular Polysaccharide Are Potent Inhibitors of Human Cytomegalovirus

Antimicrobial Agents and Chemotherapy, 2010-11, Vol.54 (11), p.4561-4567

2010

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The 6-Aminoquinolone WC5 Inhibits Human Cytomegalovirus Replication at an Early Stage by Interfering with the Transactivating Activity of Viral Immediate-Early 2 Protein

Antimicrobial Agents and Chemotherapy, 2010-05, Vol.54 (5), p.1930-1940

2010

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The Carboxy-Terminal Segment of the Human Cytomegalovirus DNA Polymerase Accessory Subunit UL44 Is Crucial for Viral Replication

Journal of Virology, 2010-11, Vol.84 (21), p.11563-11568

2010

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Drug Repurposing for Viral Infectious Diseases: How Far Are We?

Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase

HPV16 E6 and E7 upregulate the histone lysine demethylase KDM2B through the c-MYC/miR-146a-5p axys

Targeted Disruption of E6/p53 Binding Exerts Broad Activity and Synergism with Paclitaxel and Topotecan against HPV-Transformed Cancer Cells

Discovery of Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant

Exploring the cycloheptathiophene-3-carboxamide scaffold to disrupt the interactions of the influenza polymerase subunits and obtain potent anti-influenza activity

Discovery of highly potent and selective influenza virus neuraminidase inhibitors targeting 150-cavity

Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives

A novel N -heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation

The Dimeric Form of HPV16 E6 Is Crucial to Drive YAP/TAZ Upregulation through the Targeting of hScrib

Structural Investigation of Cycloheptathiophene-3-carboxamide Derivatives Targeting Influenza Virus Polymerase Assembly

Contemporary medicinal chemistry strategies for the discovery and optimization of influenza inhibitors targeting vRNP constituent proteins

Small-Molecule Inhibitor of Flaviviral NS3-NS5 Interaction with Broad-Spectrum Activity and Efficacy In Vivo

Divide et impera: An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication

Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses

A point mutation in a herpesvirus polymerase determines neuropathogenicity

Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on "The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts"

HPV-induced cancers: preclinical therapeutic advancements

Human cytomegalovirus DNA replication: antiviral targets and drugs

The human cytomegalovirus DNA polymerase processivity factor UL44 is modified by SUMO in a DNA-dependent manner

Daclatasvir plasma level and resistance selection in HIV patients with hepatitis C virus cirrhosis treated with daclatasvir, sofosbuvir, and ribavirin

Analysis of the Association of the Human Cytomegalovirus DNA Polymerase Subunit UL44 with the Viral DNA Replication Factor UL84

Sulfated Derivatives of Escherichia coli K5 Capsular Polysaccharide Are Potent Inhibitors of Human Cytomegalovirus

The 6-Aminoquinolone WC5 Inhibits Human Cytomegalovirus Replication at an Early Stage by Interfering with the Transactivating Activity of Viral Immediate-Early 2 Protein

The Carboxy-Terminal Segment of the Human Cytomegalovirus DNA Polymerase Accessory Subunit UL44 Is Crucial for Viral Replication

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