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Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans

Drug metabolism and disposition, 2009-03, Vol.37 (3), p.536

2009

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Strategies and chemical design approaches to reduce the potential for formation of reactive metabolic species

Current topics in medicinal chemistry, 2011-02, Vol.11 (4), p.419

2011

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Physiologically based pharmacokinetic modeling for assessing the clinical drug–drug interaction of alisporivir

European journal of pharmaceutical sciences, 2014-10, Vol.63, p.103-112

2014

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Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects

Drug metabolism and disposition, 2004-05, Vol.32 (5), p.566

2004

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Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions

Drug metabolism and disposition, 2017-12, Vol.45 (12), p.1304-1316

2017

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N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity

Antimicrobial Agents and Chemotherapy, 2002-09, Vol.46 (9), p.2752-2764

2002

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Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline

Xenobiotica, 2017-08, Vol.47 (8), p.682-696

2017

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Disposition and metabolism of [14C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects

Xenobiotica, 2016-11, Vol.46 (11), p.986-1000

2016

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Pharmacokinetics and metabolism of nateglinide in humans

Drug metabolism and disposition, 2001-04, Vol.29 (4 Pt 1), p.415

2001

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Compelling Relationship of CYP3A Induction to Levels of the Putative Biomarker 4β-Hydroxycholesterol and Changes in Midazolam Exposure

Clinical pharmacology in drug development, 2016-07, Vol.5 (4), p.245-249

2016

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KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.672-682

2016

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Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent

Drug metabolism and disposition, 2016-10, Vol.44 (10), p.1697-1708

2016

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Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.653-664

2016

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An industry perspective on tiered approach to the investigation of metabolites in drug development

Bioanalysis, 2014-03, Vol.6 (5), p.617-628

2014

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Clinical pharmacology of lumiracoxib : A selective cyclo-oxygenase-2 inhibitor

Clinical pharmacokinetics, 2005-01, Vol.44 (12), p.1247-1266

2005

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Compelling Relationship of CYP3A Induction to Levels of the Putative Biomarker 4[beta]-Hydroxycholesterol and Changes in Midazolam Exposure

Clinical pharmacology in drug development, 2016-07, Vol.5 (4), p.245

2016

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Synthesis and enantioselective mutagenicity of azidoalanine in Salmonella typhimurium

Chemico-biological interactions, 1986-11, Vol.60 (2), p.183-190

1986

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Oxidative Metabolism of Epothilones A and B (Patupilone) by Cytochromes P450: Involvement of CYP3A and CYP2C

The open drug metabolism journal, 2008-12, Vol.2 (1), p.14-23

2008

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Stereochemical aspects of conjugation reactions catalyzed by rat liver glutathione S-transferase isozymes

Journal of medicinal chemistry, 1983-01, Vol.26 (1), p.66-71

1983

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Conformationally defined aromatic amino acids. Synthesis and stereochemistry of 2-endo- and 2-exo-amino-1,2,3,4-tetrahydro-1,4-ethanonaphthalene-2-carboxylic acids (2-endo- and 2-exo-aminobenzobicyclo[2.2.2]octene-2-carboxylic acids)

Journal of medicinal chemistry, 1980-07, Vol.23 (7), p.754-758

1980

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Sulfation of Di- and Tricyclic Phenols by Rat Liver Aryl Sulfotransferase Isozymes

Archives of biochemistry and biophysics, 1994-05, Vol.310 (2), p.325-331

1994

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Self-catalyzed irreversible inactivation of rat hepatic aryl sulfotransferase IV by Nhydroxy-2-acetylaminofluorene

Carcinogenesis (New York), 1990-09, Vol.11 (9), p.1563-1567

1990

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Sulfation of mono- and diaryl oximes by aryl sulfotransferase isozymes

Biochimica et biophysica acta. General subjects, 1989-06, Vol.991 (3), p.453-458

1989

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Selective protein arylation by acetaminophen and 2,6-dimethylacetaminophen in cultured hepatocytes from phenobarbital-induced and uninduced mice: Relationship to cytotoxicity

Biochemical pharmacology, 1989-12, Vol.38 (24), p.4429-4438

1989

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Self-catalyzed irreversible inactivation of rat hepatic aryl sulfotransferase IV by N-hydroxy-2-acetylaminofluorene

Carcinogenesis (New York), 1990-09, Vol.11 (9), p.1563-1567

1990

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Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans

Strategies and chemical design approaches to reduce the potential for formation of reactive metabolic species

Physiologically based pharmacokinetic modeling for assessing the clinical drug–drug interaction of alisporivir

Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects

Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions

N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity

Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline

Disposition and metabolism of [14C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects

Pharmacokinetics and metabolism of nateglinide in humans

Compelling Relationship of CYP3A Induction to Levels of the Putative Biomarker 4β-Hydroxycholesterol and Changes in Midazolam Exposure

KAE609 (Cipargamin), a New Spiroindolone Agent for the Treatment of Malaria: Evaluation of the Absorption, Distribution, Metabolism, and Excretion of a Single Oral 300-mg Dose of [14C]KAE609 in Healthy Male Subjects

Utilization of Stable Isotope Labeling to Facilitate the Identification of Polar Metabolites of KAF156, an Antimalarial Agent

Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans

An industry perspective on tiered approach to the investigation of metabolites in drug development

Clinical pharmacology of lumiracoxib : A selective cyclo-oxygenase-2 inhibitor

Compelling Relationship of CYP3A Induction to Levels of the Putative Biomarker 4[beta]-Hydroxycholesterol and Changes in Midazolam Exposure

Synthesis and enantioselective mutagenicity of azidoalanine in Salmonella typhimurium

Oxidative Metabolism of Epothilones A and B (Patupilone) by Cytochromes P450: Involvement of CYP3A and CYP2C

Stereochemical aspects of conjugation reactions catalyzed by rat liver glutathione S-transferase isozymes

Conformationally defined aromatic amino acids. Synthesis and stereochemistry of 2-endo- and 2-exo-amino-1,2,3,4-tetrahydro-1,4-ethanonaphthalene-2-carboxylic acids (2-endo- and 2-exo-aminobenzobicyclo[2.2.2]octene-2-carboxylic acids)

Sulfation of Di- and Tricyclic Phenols by Rat Liver Aryl Sulfotransferase Isozymes

Self-catalyzed irreversible inactivation of rat hepatic aryl sulfotransferase IV by Nhydroxy-2-acetylaminofluorene

Sulfation of mono- and diaryl oximes by aryl sulfotransferase isozymes

Selective protein arylation by acetaminophen and 2,6-dimethylacetaminophen in cultured hepatocytes from phenobarbital-induced and uninduced mice: Relationship to cytotoxicity

Self-catalyzed irreversible inactivation of rat hepatic aryl sulfotransferase IV by N-hydroxy-2-acetylaminofluorene

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