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Pharmacokinetic-Pharmacodynamic Relationships of Imatinib and Its Main Metabolite in Patients with Advanced Gastrointestinal Stromal Tumors

Clinical cancer research, 2006-10, Vol.12 (20), p.6073-6078

2006

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Metabolism of sanguinarine in human and in rat: Characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography–tandem mass spectrometry

Journal of pharmaceutical and biomedical analysis, 2010-07, Vol.52 (3), p.391-397

2010

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Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice

Drug metabolism and disposition, 2008-08, Vol.36 (8), p.1570

2008

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Comparative transplacental transfer of taxanes using the human perfused cotyledon placental model

American journal of obstetrics and gynecology, 2012-12, Vol.207 (6), p.514.e1-514.e7

2012

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Metabolism of Irinotecan (CPT-11) by CYP3A4 and CYP3A5 in Humans

Clinical cancer research, 2000-05, Vol.6 (5), p.2012

2000

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New ifosfamide analogs designed for lower associated neurotoxicity and nephrotoxicity with modified alkylating kinetics leading to enhanced in vitro anticancer activity

The Journal of pharmacology and experimental therapeutics, 2009-02, Vol.328 (2), p.598

2009

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Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues

European journal of medicinal chemistry, 2021-11, Vol.223, p.113656-113656, Article 113656

2021

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Induction of glutathione synthesis explains pharmacodynamics of high-dose busulfan in mice and highlights putative mechanisms of drug interaction

Drug metabolism and disposition, 2007-02, Vol.35 (2), p.306

2007

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1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation

Journal of medicinal chemistry, 2019-02, Vol.62 (4), p.1902-1916

2019

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Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors

European journal of medicinal chemistry, 2022-10, Vol.240, p.114573-114573, Article 114573

2022

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Pharmacokinetics, metabolism, and routes of excretion of intravenous irofulven in patients with advanced solid tumors

Drug metabolism and disposition, 2006-11, Vol.34 (11), p.1918

2006

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Poly-isoprenylated ifosfamide analogs: Preactivated antitumor agents as free formulation or nanoassemblies

International journal of pharmaceutics, 2017-11, Vol.532 (2), p.748-756

2017

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Busulfan disposition and hepatic veno-occlusive disease in children undergoing bone marrow transplantation

Cancer chemotherapy and pharmacology, 1996-01, Vol.37 (3), p.247-253

1996

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Oxazaphosphorines: new therapeutic strategies for an old class of drugs

Expert opinion on drug metabolism & toxicology, 2010-08, Vol.6 (8), p.919-938

2010

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Iron Overload Exacerbates Busulfan-Melphalan Toxicity Through a Pharmacodynamic Interaction in Mice

Pharmaceutical research, 2016-08, Vol.33 (8), p.1913-1922

2016

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Abstract 4537: Geranyloxy-ifosfamide: A pre-activated ifosfamide analogue showing an increased therapeutic index

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.4537-4537

2015

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Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography–tandem mass spectrometry in mouse plasma and its application to a pharmacokinetic study

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015-06, Vol.992, p.30-35

2015

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Self-association and Domains of Interactions of an Amphipathic Helix Peptide Inhibitor of HIV-1 Integrase Assessed by Analytical Ultracentrifugation and NMR Experiments in Trifluoroethanol/H2O Mixtures

The Journal of biological chemistry, 1999-11, Vol.274 (48), p.34174-34185

1999

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Preactivated Oxazaphosphorines Designed for Isophosphoramide Mustard Delivery as Bulk Form or Nanoassemblies: Synthesis and Proof of Concept

Journal of medicinal chemistry, 2015-01, Vol.58 (2), p.705-717

2015

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Liquid chromatography–tandem mass spectrometry assay of reduced and oxidized glutathione and main precursors in mice liver

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006-02, Vol.832 (1), p.67-74

2006

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Abstract 3358: Pharmacokinetic investigation of unbound vandetanib in patients with medullary thyroid carcinoma using liquid chromatography-tandem mass spectrometry

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.3358-3358

2013

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Abstract 5671: Enhanced activity of pre-activated oxazaphosphorine prodrugs designed for drug delivery strategy: influence of the length of the engrafted group

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.5671-5671

2013

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Abstract 5471: Pharmacokinetic investigation of vandetanib in patients with medullary thyroid carcinoma using liquid chromatography-tandem mass spectrometry

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.5471-5471

2011

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Metabolism evaluation of biomimetic prodrugs by in vitro models and mass spectrometry

International journal of pharmaceutics, 2009-09, Vol.379 (2), p.235-243

2009

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Simultaneous determination of gemcitabine and gemcitabine-squalene by liquid chromatography–tandem mass spectrometry in human plasma

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007-10, Vol.858 (1), p.71-78

2007

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Pharmacokinetic-Pharmacodynamic Relationships of Imatinib and Its Main Metabolite in Patients with Advanced Gastrointestinal Stromal Tumors

Metabolism of sanguinarine in human and in rat: Characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography–tandem mass spectrometry

Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice

Comparative transplacental transfer of taxanes using the human perfused cotyledon placental model

Metabolism of Irinotecan (CPT-11) by CYP3A4 and CYP3A5 in Humans

New ifosfamide analogs designed for lower associated neurotoxicity and nephrotoxicity with modified alkylating kinetics leading to enhanced in vitro anticancer activity

Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues

Induction of glutathione synthesis explains pharmacodynamics of high-dose busulfan in mice and highlights putative mechanisms of drug interaction

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation

Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors

Pharmacokinetics, metabolism, and routes of excretion of intravenous irofulven in patients with advanced solid tumors

Poly-isoprenylated ifosfamide analogs: Preactivated antitumor agents as free formulation or nanoassemblies

Busulfan disposition and hepatic veno-occlusive disease in children undergoing bone marrow transplantation

Oxazaphosphorines: new therapeutic strategies for an old class of drugs

Iron Overload Exacerbates Busulfan-Melphalan Toxicity Through a Pharmacodynamic Interaction in Mice

Abstract 4537: Geranyloxy-ifosfamide: A pre-activated ifosfamide analogue showing an increased therapeutic index

Simultaneous quantification of preactivated ifosfamide derivatives and of 4-hydroxyifosfamide by high performance liquid chromatography–tandem mass spectrometry in mouse plasma and its application to a pharmacokinetic study

Self-association and Domains of Interactions of an Amphipathic Helix Peptide Inhibitor of HIV-1 Integrase Assessed by Analytical Ultracentrifugation and NMR Experiments in Trifluoroethanol/H2O Mixtures

Preactivated Oxazaphosphorines Designed for Isophosphoramide Mustard Delivery as Bulk Form or Nanoassemblies: Synthesis and Proof of Concept

Liquid chromatography–tandem mass spectrometry assay of reduced and oxidized glutathione and main precursors in mice liver

Abstract 3358: Pharmacokinetic investigation of unbound vandetanib in patients with medullary thyroid carcinoma using liquid chromatography-tandem mass spectrometry

Abstract 5671: Enhanced activity of pre-activated oxazaphosphorine prodrugs designed for drug delivery strategy: influence of the length of the engrafted group

Abstract 5471: Pharmacokinetic investigation of vandetanib in patients with medullary thyroid carcinoma using liquid chromatography-tandem mass spectrometry

Metabolism evaluation of biomimetic prodrugs by in vitro models and mass spectrometry

Simultaneous determination of gemcitabine and gemcitabine-squalene by liquid chromatography–tandem mass spectrometry in human plasma

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