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Structure- and Property-Based Design of Aminooxazoline Xanthenes as Selective, Orally Efficacious, and CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer’s Disease

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9156-9169

2012

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Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (16), p.3817-3824

2017

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement

ACS medicinal chemistry letters, 2016-12, Vol.7 (12), p.1062-1067

2016

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.5990-6017

2017

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Neuroactive Steroid N‑Methyl‑d‑aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity

Journal of medicinal chemistry, 2019-08, Vol.62 (16), p.7526-7542

2019

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Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.5969-5989

2017

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Catalytic Asymmetric Ring-Opening Metathesis/Cross Metathesis (AROM/CM) Reactions. Mechanism and Application to Enantioselective Synthesis of Functionalized Cyclopentanes

Journal of the American Chemical Society, 2001-08, Vol.123 (32), p.7767-7778

2001

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Catalytic Enantioselective Ring-Closing Metathesis by a Chiral Biphen−Mo Complex

Journal of the American Chemical Society, 1998-04, Vol.120 (16), p.4041-4042

1998

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Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9009-9024

2012

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Chiral Mo−Binol Complexes: Activity, Synthesis, and Structure. Efficient Enantioselective Six-Membered Ring Synthesis through Catalytic Metathesis

Journal of the American Chemical Society, 1999-09, Vol.121 (36), p.8251-8259

1999

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The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (15), p.3477-3485

2017

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1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (11), p.2103-2108

2018

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Mo-Catalyzed Asymmetric Synthesis of Dihydrofurans. Catalytic Kinetic Resolution and Enantioselective Desymmetrization through Ring-Closing Metathesis

Journal of the American Chemical Society, 1998-09, Vol.120 (37), p.9720-9721

1998

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Chromenes through Metal-Catalyzed Reactions of Styrenyl Ethers. Mechanism and Utility in Synthesis

Journal of the American Chemical Society, 1998-03, Vol.120 (10), p.2343-2351

1998

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1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of Na V 1.7 inhibition

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (11), p.2103-2108

2018

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Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9025-9044

2012

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Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.5969-5989

2017

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Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Journal of medicinal chemistry, 2017-07, Vol.60 (14), p.5990-6017

2017

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The discovery of benzoxazine sulfonamide inhibitors of Na V 1.7: Tools that bridge efficacy and target engagement

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (15), p.3477-3485

2017

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Applications of Zr-Catalyzed Carbomagnesation and Mo-Catalyzed Macrocyclic Ring Closing Metathesis in Asymmetric Synthesis. Enantioselective Total Synthesis of Sch 38516 (Fluvirucin B1)

Journal of the American Chemical Society, 1997-10, Vol.119 (43), p.10302-10316

1997

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Discovery of triazine-benzimidazoles as selective inhibitors of mTOR

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (7), p.2064-2070

2011

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Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement

ACS medicinal chemistry letters, 2016-12, Vol.7 (12), p.1062-1067

2016

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Correction to "Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement"

ACS medicinal chemistry letters, 2017-03, Vol.8 (3), p.378-378

2017

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Correction to “Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement”

ACS medicinal chemistry letters, 2017-03, Vol.8 (3), p.378-378

2017

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Novel 2,3-Dihydro-1,4-Benzoxazines as Potent and Orally Bioavailable Inhibitors of Tumor-Driven Angiogenesis

Journal of medicinal chemistry, 2008-03, Vol.51 (6), p.1695-1705

2008

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Structure- and Property-Based Design of Aminooxazoline Xanthenes as Selective, Orally Efficacious, and CNS Penetrable BACE Inhibitors for the Treatment of Alzheimer’s Disease

Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

Neuroactive Steroid N‑Methyl‑d‑aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity

Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities

Catalytic Asymmetric Ring-Opening Metathesis/Cross Metathesis (AROM/CM) Reactions. Mechanism and Application to Enantioselective Synthesis of Functionalized Cyclopentanes

Catalytic Enantioselective Ring-Closing Metathesis by a Chiral Biphen−Mo Complex

Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

Chiral Mo−Binol Complexes: Activity, Synthesis, and Structure. Efficient Enantioselective Six-Membered Ring Synthesis through Catalytic Metathesis

The discovery of benzoxazine sulfonamide inhibitors of NaV1.7: Tools that bridge efficacy and target engagement

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition

Mo-Catalyzed Asymmetric Synthesis of Dihydrofurans. Catalytic Kinetic Resolution and Enantioselective Desymmetrization through Ring-Closing Metathesis

Chromenes through Metal-Catalyzed Reactions of Styrenyl Ethers. Mechanism and Utility in Synthesis

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of Na V 1.7 inhibition

Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency and Pharmacokinetics While Mitigating Metabolic Liabilities

Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency, Pharmacokinetics, and Metabolic Properties to Obtain Atropisomeric Quinolinone (AM-0466) that Affords Robust in Vivo Activity

The discovery of benzoxazine sulfonamide inhibitors of Na V 1.7: Tools that bridge efficacy and target engagement

Applications of Zr-Catalyzed Carbomagnesation and Mo-Catalyzed Macrocyclic Ring Closing Metathesis in Asymmetric Synthesis. Enantioselective Total Synthesis of Sch 38516 (Fluvirucin B1)

Discovery of triazine-benzimidazoles as selective inhibitors of mTOR

Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement

Correction to "Sulfonamides as Selective Na V 1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement"

Correction to “Sulfonamides as Selective NaV1.7 Inhibitors: Optimizing Potency and Pharmacokinetics to Enable in Vivo Target Engagement”

Novel 2,3-Dihydro-1,4-Benzoxazines as Potent and Orally Bioavailable Inhibitors of Tumor-Driven Angiogenesis

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