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The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM

Journal of molecular biology, 2019-03, Vol.431 (7), p.1440-1459

2019

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Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I Nai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties

Journal of medicinal chemistry, 2016-10, Vol.59 (19), p.9005-9017

2016

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Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (13), p.3207-3211

2016

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Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (13), p.3202-3206

2016

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Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII)

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (3), p.541-546

2018

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Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.2048-2052

2009

Volltextzugriff (PDF)

Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors

Bioorganic & medicinal chemistry letters, 2009-08, Vol.19 (15), p.4070-4074

2009

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Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors

Bioorganic & medicinal chemistry letters, 2009-06, Vol.19 (11), p.3050-3053

2009

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CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (24), p.6017-6021

2004

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New fatty acid oxidation inhibitors with increased potency lacking adverse metabolic and electrophysiological properties

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (2), p.549-552

2004

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An NMR Strategy for Determination of Configuration of Remote Stereogenic Centers: 3-Methylcarboxylic Acids

Journal of the American Chemical Society, 1998-05, Vol.120 (19), p.4638-4643

1998

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An NMR method for determination of configuration of β-substituted carboxylic acids

Tetrahedron letters, 2000-04, Vol.41 (14), p.2289-2293

2000

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N-Methylputrescine Oxidation during Cocaine Biosynthesis: Study of Prochiral Methylene Hydrogen Discrimination Using the Remote Isotope Method

Organic letters, 2000-01, Vol.2 (1), p.3-5

2000

Volltextzugriff (PDF)

Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late I Na i) of the cardiac Na V 1.5 channel with improved efficacy and potency relative to ranolazine

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (13), p.3202-3206

2016

Volltextzugriff (PDF)

Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late I Na i) of the cardiac Na v 1.5 channel with improved efficacy and potency relative to ranolazine

Bioorganic & medicinal chemistry letters, 2016-07, Vol.26 (13), p.3207-3211

2016

Volltextzugriff (PDF)

The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca 2+ /CaM

Journal of molecular biology, 2019-03, Vol.431 (7), p.1440

2019

Volltextzugriff (PDF)

A new approach to the synthesis of linearly fused triquinanes

Tetrahedron letters, 1995-06, Vol.36 (26), p.4651-4654

1995

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Enzymatic Targets in the Triglyceride Synthesis Pathway

Annual Reports in Medicinal Chemistry, 2010, Vol.45, p.109-122

2010

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Synthesis of Conformationally Mobile Bicyclic Tetrahydro-1,2-oxazines by Isomerization of Isoxazolidinylmethyl Tosylates

Journal of organic chemistry, 1998-06, Vol.63 (13), p.4485-4488

1998

Volltextzugriff (PDF)

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (7), p.2048-2052

2009

Volltextzugriff (PDF)

Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (15), p.4070-4074

2009

Volltextzugriff (PDF)

Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (11), p.3050-3053

2009

Volltextzugriff (PDF)

Microwave-Assisted One-Step Synthesis of Substituted 2-Chloromethyl-1,3,4-oxadiazoles

Synthetic communications, 2004, Vol.34 (14), p.2523-2529

2004

Volltextzugriff (PDF)

Microwave-Assisted One-Step Synthesis of Substituted 2-Chloromethyl-1,3,4-oxadiazoles

ChemInform, 2004-12, Vol.35 (50), p.no-no

2004

Volltextzugriff (PDF)

New Fatty Acid Oxidation Inhibitors with Increased Potency Lacking Adverse Metabolic and Electrophysiological Properties

ChemInform, 2004-04, Vol.35 (16), p.no-no

2004

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The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca2+/CaM

Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I Nai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties

Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine

Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine

Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII)

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors

Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors

CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability

New fatty acid oxidation inhibitors with increased potency lacking adverse metabolic and electrophysiological properties

An NMR Strategy for Determination of Configuration of Remote Stereogenic Centers: 3-Methylcarboxylic Acids

An NMR method for determination of configuration of β-substituted carboxylic acids

N-Methylputrescine Oxidation during Cocaine Biosynthesis: Study of Prochiral Methylene Hydrogen Discrimination Using the Remote Isotope Method

Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late I Na i) of the cardiac Na V 1.5 channel with improved efficacy and potency relative to ranolazine

Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late I Na i) of the cardiac Na v 1.5 channel with improved efficacy and potency relative to ranolazine

The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca 2+ /CaM

A new approach to the synthesis of linearly fused triquinanes

Enzymatic Targets in the Triglyceride Synthesis Pathway

Synthesis of Conformationally Mobile Bicyclic Tetrahydro-1,2-oxazines by Isomerization of Isoxazolidinylmethyl Tosylates

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors

Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors

Microwave-Assisted One-Step Synthesis of Substituted 2-Chloromethyl-1,3,4-oxadiazoles

Microwave-Assisted One-Step Synthesis of Substituted 2-Chloromethyl-1,3,4-oxadiazoles

New Fatty Acid Oxidation Inhibitors with Increased Potency Lacking Adverse Metabolic and Electrophysiological Properties

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