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Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease

Movement disorders, 2003-11, Vol.18 (11), p.1332-1337

2003

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Frequency and phenotype of SPG11 and SPG15 in complicated spastic paraplegia (HSP)

Journal of neurology, neurosurgery and psychiatry, 2009-11, Vol.80 (12)

2009

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Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients

Annals of neurology, 2016-04, Vol.79 (4), p.646-658

2016

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A New Method to Detect Related Function Among Proteins Independent of Sequence and Fold Homology

Journal of molecular biology, 2002-10, Vol.323 (2), p.387-406

2002

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High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits

Structure (London), 2016-08, Vol.24 (8), p.1398-1409

2016

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Thermodynamics of protein–ligand interactions as a reference for computational analysis: how to assess accuracy, reliability and relevance of experimental data

Journal of computer-aided molecular design, 2015-09, Vol.29 (9), p.867-883

2015

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Impact of Surface Water Layers on Protein–Ligand Binding: How Well Are Experimental Data Reproduced by Molecular Dynamics Simulations in a Thermolysin Test Case?

Journal of chemical information and modeling, 2016-01, Vol.56 (1), p.223-233

2016

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Rational Design of Thermodynamic and Kinetic Binding Profiles by Optimizing Surface Water Networks Coating Protein-Bound Ligands

Journal of medicinal chemistry, 2016-12, Vol.59 (23), p.10530-10548

2016

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Paying the Price of Desolvation in Solvent-Exposed Protein Pockets: Impact of Distal Solubilizing Groups on Affinity and Binding Thermodynamics in a Series of Thermolysin Inhibitors

Journal of medicinal chemistry, 2017-07, Vol.60 (13), p.5791-5799

2017

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How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S 1 ' Pocket of Thermolysin

Journal of the American Chemical Society, 2017-08, Vol.139 (30), p.10419-10431

2017

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Methyl, Ethyl, Propyl, Butyl: Futile But Not for Water, as the Correlation of Structure and Thermodynamic Signature Shows in a Congeneric Series of Thermolysin Inhibitors

ChemMedChem, 2014-04, Vol.9 (4), p.833-846

2014

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How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S1′ Pocket of Thermolysin

Journal of the American Chemical Society, 2017-08, Vol.139 (30), p.10419-10431

2017

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Magnet for the Needle in Haystack: “Crystal Structure First” Fragment Hits Unlock Active Chemical Matter Using Targeted Exploration of Vast Chemical Spaces

Journal of medicinal chemistry, 2022-12, Vol.65 (23), p.15663-15678

2022

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Management of delirium in Parkinson’s disease

Journal of Neural Transmission, 2019-07, Vol.126 (7), p.905-912

2019

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Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins?

Journal of medicinal chemistry, 2020-03, Vol.63 (6), p.3274-3289

2020

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Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study

ACS chemical biology, 2016-06, Vol.11 (6), p.1693-1701

2016

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The cardiomyopathy in Friedreich's ataxia — New biomarker for staging cardiac involvement

International journal of cardiology, 2015-09, Vol.194, p.50-57

2015

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Fragments as Novel Starting Points for tRNA‐Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies

ChemMedChem, 2020-02, Vol.15 (3), p.324-337

2020

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Resource Utilization of Patients with Parkinson’s Disease in the Late Stages of the Disease in Germany: Data from the CLaSP Study

PharmacoEconomics, 2021-05, Vol.39 (5), p.601-615

2021

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Elucidating the Origin of Long Residence Time Binding for Inhibitors of the Metalloprotease Thermolysin

ACS chemical biology, 2017-01, Vol.12 (1), p.225-233

2017

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Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor

Neurology, 2012-07, Vol.79 (3), p.243-248

2012

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Care of Late‐Stage Parkinsonism: Resource Utilization of the Disease in Five European Countries

Movement disorders, 2024-03, Vol.39 (3), p.571-584

2024

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From the Similarity Analysis of Protein Cavities to the Functional Classification of Protein Families Using Cavbase

Journal of molecular biology, 2006-06, Vol.359 (4), p.1023-1044

2006

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Impact of protein and ligand impurities on ITC-derived protein–ligand thermodynamics

Biochimica et biophysica acta, 2014-09, Vol.1840 (9), p.2843-2850

2014

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Pharmacotherapy of motor symptoms in early and mid-stage Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology

Journal of neurology, 2024-08

2024

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Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease

Frequency and phenotype of SPG11 and SPG15 in complicated spastic paraplegia (HSP)

Hereditary spastic paraplegia: Clinicogenetic lessons from 608 patients

A New Method to Detect Related Function Among Proteins Independent of Sequence and Fold Homology

High-Throughput Crystallography: Reliable and Efficient Identification of Fragment Hits

Thermodynamics of protein–ligand interactions as a reference for computational analysis: how to assess accuracy, reliability and relevance of experimental data

Impact of Surface Water Layers on Protein–Ligand Binding: How Well Are Experimental Data Reproduced by Molecular Dynamics Simulations in a Thermolysin Test Case?

Rational Design of Thermodynamic and Kinetic Binding Profiles by Optimizing Surface Water Networks Coating Protein-Bound Ligands

Paying the Price of Desolvation in Solvent-Exposed Protein Pockets: Impact of Distal Solubilizing Groups on Affinity and Binding Thermodynamics in a Series of Thermolysin Inhibitors

How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S 1 ' Pocket of Thermolysin

Methyl, Ethyl, Propyl, Butyl: Futile But Not for Water, as the Correlation of Structure and Thermodynamic Signature Shows in a Congeneric Series of Thermolysin Inhibitors

How Nothing Boosts Affinity: Hydrophobic Ligand Binding to the Virtually Vacated S1′ Pocket of Thermolysin

Magnet for the Needle in Haystack: “Crystal Structure First” Fragment Hits Unlock Active Chemical Matter Using Targeted Exploration of Vast Chemical Spaces

Management of delirium in Parkinson’s disease

Protein-Induced Change in Ligand Protonation during Trypsin and Thrombin Binding: Hint on Differences in Selectivity Determinants of Both Proteins?

Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study

The cardiomyopathy in Friedreich's ataxia — New biomarker for staging cardiac involvement

Fragments as Novel Starting Points for tRNA‐Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies

Resource Utilization of Patients with Parkinson’s Disease in the Late Stages of the Disease in Germany: Data from the CLaSP Study

Elucidating the Origin of Long Residence Time Binding for Inhibitors of the Metalloprotease Thermolysin

Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor

Care of Late‐Stage Parkinsonism: Resource Utilization of the Disease in Five European Countries

From the Similarity Analysis of Protein Cavities to the Functional Classification of Protein Families Using Cavbase

Impact of protein and ligand impurities on ITC-derived protein–ligand thermodynamics

Pharmacotherapy of motor symptoms in early and mid-stage Parkinson’s disease: guideline “Parkinson’s disease” of the German Society of Neurology

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