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Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies

Drug discovery today. Technologies, 2016-09, Vol.21-22, p.75-83

Kamath, Amrita V.

2016

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Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging

PloS one, 2019-10, Vol.14 (10), p.e0224096-e0224096

2019

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Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper

mAbs, 2022-12, Vol.14 (1), p.2145997

2022

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A novel approach to quantitate biodistribution and transduction of adeno-associated virus gene therapy using radiolabeled AAV vectors in mice

Molecular therapy. Methods & clinical development, 2024-09, Vol.32 (3), p.101326, Article 101326

2024

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Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies

mAbs, 2022-12, Vol.14 (1), p.2085535-2085535

2022

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Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates

Pharmaceutical research, 2015-11, Vol.32 (11), p.3470-3479

2015

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Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL

Cancer chemotherapy and pharmacology, 2008-03, Vol.61 (3), p.365-376

2008

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Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics

Frontiers in pharmacology, 2021-05, Vol.12, p.601569-601569

2021

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A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule

Pharmaceutics, 2024-05, Vol.16 (5), p.660

2024

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Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy

Frontiers in pharmacology, 2024-06, Vol.15, p.1380000

2024

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Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data

Clinical and translational science, 2019-09, Vol.12 (5), p.534-544

2019

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Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent for B Cell Malignancies

Pharmaceutics, 2022-04, Vol.14 (5), p.970

2022

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Challenges and advances in the assessment of the disposition of antibody-drug conjugates

Biopharmaceutics & drug disposition, 2016-03, Vol.37 (2), p.66-74

2016

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A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti- Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers

Antimicrobial agents and chemotherapy, 2019-06, Vol.63 (6)

2019

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Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

Bioorganic & medicinal chemistry letters, 2020-02, Vol.30 (4), p.126907, Article 126907

2020

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Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development

Xenobiotica, 2024-09, Vol.54 (8), p.1-551

2024

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Effect of Fruit Juices on the Oral Bioavailability of Fexofenadine in Rats

Journal of pharmaceutical sciences, 2005-02, Vol.94 (2), p.233-239

2005

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Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma

The AAPS journal, 2022-09, Vol.24 (6), p.100, Article 100

2022

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Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti- Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats

Drug metabolism and disposition, 2020-11, Vol.48 (11), p.1161-1168

2020

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Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of Biologics

Molecular cancer therapeutics, 2021-10, Vol.20 (10), p.2008-2015

2021

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Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

Pharmacology research & perspectives, 2020-04, Vol.8 (2), p.e00573-n/a

2020

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Calicheamicin Antibody-Drug Conjugates with Improved Properties

Molecular cancer therapeutics, 2021-06, Vol.20 (6), p.1112-1120

2021

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Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus

mAbs, 2019-08, Vol.11 (6), p.1162-1174

2019

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A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK

The AAPS journal, 2024-01, Vol.26 (1), p.11-11, Article 11

2024

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Translational pharmacokinetics and pharmacodynamics of monoclonal antibodies

Sustained activity of novel THIOMAB antibody-antibiotic conjugate against Staphylococcus aureus in a mouse model: Longitudinal pharmacodynamic assessment by bioluminescence imaging

Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper

A novel approach to quantitate biodistribution and transduction of adeno-associated virus gene therapy using radiolabeled AAV vectors in mice

Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies

Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates

Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL

Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics

A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule

Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy

Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data

Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent for B Cell Malignancies

Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity

Challenges and advances in the assessment of the disposition of antibody-drug conjugates

A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti- Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development

Effect of Fruit Juices on the Oral Bioavailability of Fexofenadine in Rats

Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple Myeloma

Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti- Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats

Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of Biologics

Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

Calicheamicin Antibody-Drug Conjugates with Improved Properties

Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus

A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK

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