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Mitomycinoid Alkaloids: Mechanism of Action, Biosynthesis, Total Syntheses, and Synthetic Approaches

Chemical reviews, 2013-08, Vol.113 (8), p.6816-6863

2013

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From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

Journal of medicinal chemistry, 2011-08, Vol.54 (16), p.5836-5857

2011

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STK33 Kinase Activity Is Nonessential in KRAS-Dependent Cancer Cells

Cancer research (Chicago, Ill.), 2011-09, Vol.71 (17), p.5818-5826

2011

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Concise Enantioselective Synthesis of (+)-FR66979 and (+)-FR900482: Dimethyldioxirane-Mediated Construction of the Hydroxylamine Hemiketal

Angewandte Chemie (International ed.), 2002-12, Vol.41 (24), p.4683-4685

2002

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An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities

ACS medicinal chemistry letters, 2015-02, Vol.6 (2), p.210-215

2015

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Access to substituted trifluoromethyl ketones using the versatile synthetic intermediate (E)-1,1-dimethyl-2-(1,1,1-trifluoropropan-2-ylidene)hydrazine

Tetrahedron letters, 2017-11, Vol.58 (47), p.4455-4458

2017

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A Concise Total Synthesis of (+)-FR900482 and (+)-FR66979

Journal of organic chemistry, 2004-04, Vol.69 (8), p.2825-2830

2004

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Structure Determination of Mycolactone C via Total Synthesis

Organic letters, 2004-12, Vol.6 (26), p.4901-4904

2004

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Synthesis and DNA Cross-Linking of a Phototriggered FR900482 Mitosene Progenitor

Organic letters, 2002-10, Vol.4 (21), p.3711-3714

2002

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Synthesis of the First Photo-Triggered Pro-mitosene Based on FR-900482

Tetrahedron, 2000-01, Vol.56 (4), p.521-532

2000

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Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Journal of medicinal chemistry, 2016-04, Vol.59 (8), p.3732-3749

2016

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Fragment-Linking Approach Using [superscript 19]F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of [beta]-Secretase

Journal of medicinal chemistry, 2016-05, Vol.59 ((8) ; 03, 2016)

2016

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Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Journal of medicinal chemistry, 2016-04, Vol.59 (8), p.3732-3749

2016

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Correction to Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β‑Secretase

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3218-3218

2017

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Correction to Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3218-3218

2017

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Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9009-9024

2012

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Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9025-9044

2012

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Abstract 253: Identification of STK33 kinase inhibitors for the validation of a synthetic lethal relationship between STK33 and mutant KRAS

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.253-253

2011

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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase

ACS medicinal chemistry letters, 2012-11, Vol.3 (11), p.886-891

2012

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ChemInform Abstract: Mitomycinoid Alkaloids: Mechanism of Action, Biosynthesis, Total Syntheses, and Synthetic Approaches

ChemInform, 2013-10, Vol.44 (41), p.no-no

2013

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P1‐243: Pharmacokinetic and pharmacodynamic evaluation of orally available hydroxyethylamine‐derived beta‐secretase inhibitors in Sprague Dawley rats

Alzheimer's & dementia, 2012-07, Vol.8 (4S_Part_5), p.P191-P192

2012

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Pharmacokinetic and pharmacodynamic evaluation of orally available hydroxyethylamine-derived beta-secretase inhibitors in Sprague Dawley rats

Alzheimer's & dementia, 2012-07, Vol.8 (4), p.P191-P192

2012

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Concise Enantioselective Synthesis of (+)-FR66979 and (+)-FR900482: Dimethyldioxirane-Mediated Construction of the Hydroxylamine Hemiketal

Angewandte Chemie, 2002-12, Vol.114 (24), p.4877-4879

2002

Volltextzugriff (PDF)

Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β‑Secretase

Journal of medicinal chemistry, 2016-04, Vol.59 (8), p.3732-3749

2016

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Mitomycinoid Alkaloids: Mechanism of Action, Biosynthesis, Total Syntheses, and Synthetic Approaches

From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

STK33 Kinase Activity Is Nonessential in KRAS-Dependent Cancer Cells

Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer’s disease

Concise Enantioselective Synthesis of (+)-FR66979 and (+)-FR900482: Dimethyldioxirane-Mediated Construction of the Hydroxylamine Hemiketal

An Orally Available BACE1 Inhibitor That Affords Robust CNS Aβ Reduction without Cardiovascular Liabilities

Access to substituted trifluoromethyl ketones using the versatile synthetic intermediate (E)-1,1-dimethyl-2-(1,1,1-trifluoropropan-2-ylidene)hydrazine

A Concise Total Synthesis of (+)-FR900482 and (+)-FR66979

Structure Determination of Mycolactone C via Total Synthesis

Synthesis and DNA Cross-Linking of a Phototriggered FR900482 Mitosene Progenitor

Synthesis of the First Photo-Triggered Pro-mitosene Based on FR-900482

Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Fragment-Linking Approach Using [superscript 19]F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of [beta]-Secretase

Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Correction to Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β‑Secretase

Correction to Fragment-Linking Approach Using 19 F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase

Design and Preparation of a Potent Series of Hydroxyethylamine Containing β-Secretase Inhibitors That Demonstrate Robust Reduction of Central β-Amyloid

Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

Abstract 253: Identification of STK33 kinase inhibitors for the validation of a synthetic lethal relationship between STK33 and mutant KRAS

A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase

ChemInform Abstract: Mitomycinoid Alkaloids: Mechanism of Action, Biosynthesis, Total Syntheses, and Synthetic Approaches

P1‐243: Pharmacokinetic and pharmacodynamic evaluation of orally available hydroxyethylamine‐derived beta‐secretase inhibitors in Sprague Dawley rats

Pharmacokinetic and pharmacodynamic evaluation of orally available hydroxyethylamine-derived beta-secretase inhibitors in Sprague Dawley rats

Concise Enantioselective Synthesis of (+)-FR66979 and (+)-FR900482: Dimethyldioxirane-Mediated Construction of the Hydroxylamine Hemiketal

Fragment-Linking Approach Using 19F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β‑Secretase

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