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Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (52), p.E5088-E5097

2013

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Snapshots of actin and tubulin folding inside the TRiC chaperonin

Nature structural & molecular biology, 2022-05, Vol.29 (5), p.420

2022

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Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state

Proceedings of the National Academy of Sciences - PNAS, 2016-10, Vol.113 (42), p.11961-11966

2016

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Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells

Proceedings of the National Academy of Sciences - PNAS, 2010-12, Vol.107 (51), p.22255-22259

2010

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Direct Interaction between an Allosteric Agonist Pepducin and the Chemokine Receptor CXCR4

Journal of the American Chemical Society, 2011-10, Vol.133 (40), p.15878-15881

2011

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Role of the Retinal Hydrogen Bond Network in Rhodopsin Schiff Base Stability and Hydrolysis

The Journal of biological chemistry, 2004-12, Vol.279 (53), p.55886-55894

2004

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Development and Characterization of Pepducins as Gs-biased Allosteric Agonists

The Journal of biological chemistry, 2014-12, Vol.289 (52), p.35668-35684

2014

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Stability of Dark State Rhodopsin Is Mediated by a Conserved Ion Pair in Intradiscal Loop E-2

The Journal of biological chemistry, 2003-05, Vol.278 (19), p.16982-16991

2003

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Inter-domain communication of human cystathionine β-synthase: structural basis of S-adenosyl-L-methionine activation

The Journal of biological chemistry, 2014-12, Vol.289 (52), p.36018

2014

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.326-342

2021

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PF‐07059013: A non‐covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease

American journal of hematology, 2021-08, Vol.96 (8), p.E272-E275

2021

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Engineering a Functional Blue-Wavelength-Shifted Rhodopsin Mutant

Biochemistry (Easton), 2001-06, Vol.40 (24), p.7219-7227

2001

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Rhodopsin activation exposes a key hydrophobic binding site for the transducin alpha-subunit C terminus

The Journal of biological chemistry, 2004-07, Vol.279 (28), p.29767-29773

2004

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G protein-coupled receptor modulation with pepducins: moving closer to the clinic

Annals of the New York Academy of Sciences, 2011-05, Vol.1226 (1), p.34-49

2011

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A Novel Interaction between Atrophin-interacting Protein 4 and β-p21-activated Kinase-interactive Exchange Factor Is Mediated by an SH3 Domain

The Journal of biological chemistry, 2007-09, Vol.282 (39), p.28893-28903

2007

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Assessing structural elements that influence Schiff base stability: mutants E113Q and D190N destabilize rhodopsin through different mechanisms

Vision research (Oxford), 2003-12, Vol.43 (28), p.2991-3002

2003

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A Novel Non-Covalent Modulator of Hemoglobin Improves Anemia and Reduces Sickling in a Mouse Model of Sickle Cell Disease

Blood, 2019-11, Vol.134 (Supplement_1), p.207-207

2019

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Decay of an Active GPCR: Conformational Dynamics Govern Agonist Rebinding and Persistence of an Active, Yet Empty, Rhodopsin State

Biophysical journal, 2017-02, Vol.112 (3), p.171a-171a

2017

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Monitoring Conformational Changes During Agonist Release from a GPCR in Real Time: Transmembrane Helix 6 Resets as All-Trans Retinal is Released from Rhodopsin

Biophysical journal, 2014-01, Vol.106 (2), p.102a-102a

2014

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Translation from SCD Mouse to Man: Chronic Administration of Tucaresol Reduces RBC Sickling and Improves Hematological Parameters, but Does Not Impact Inflammatory Markers in SCD Model Mice

Blood, 2016-12, Vol.128 (22), p.3644-3644

2016

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CCT5: A Model Protein Folding Machine

Biophysical journal, 2015-01, Vol.108 (2), p.52a-52a

2015

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Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (52), p.20862-20862

2013

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Inter-domain Communication of Human Cystathionine β-Synthase: STRUCTURAL BASIS OF S-ADENOSYL

The Journal of biological chemistry, 2014-10, Vol.289 (52), p.36018-36030

2014

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Crystal Structure of the SH3 Domain of βPIX in Complex with a High Affinity Peptide from PAK2

Journal of molecular biology, 2006-04, Vol.358 (2), p.509-522

2006

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A Novel Interaction between Atrophin-interacting Protein 4 and Î²-p21-activated Kinase-interactive Exchange Factor Is Mediated by an SH3 Domain

The Journal of biological chemistry, 2007-09, Vol.282 (39), p.28893

2007

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Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

Snapshots of actin and tubulin folding inside the TRiC chaperonin

Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state

Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells

Direct Interaction between an Allosteric Agonist Pepducin and the Chemokine Receptor CXCR4

Role of the Retinal Hydrogen Bond Network in Rhodopsin Schiff Base Stability and Hydrolysis

Development and Characterization of Pepducins as Gs-biased Allosteric Agonists

Stability of Dark State Rhodopsin Is Mediated by a Conserved Ion Pair in Intradiscal Loop E-2

Inter-domain communication of human cystathionine β-synthase: structural basis of S-adenosyl-L-methionine activation

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

PF‐07059013: A non‐covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease

Engineering a Functional Blue-Wavelength-Shifted Rhodopsin Mutant

Rhodopsin activation exposes a key hydrophobic binding site for the transducin alpha-subunit C terminus

G protein-coupled receptor modulation with pepducins: moving closer to the clinic

A Novel Interaction between Atrophin-interacting Protein 4 and β-p21-activated Kinase-interactive Exchange Factor Is Mediated by an SH3 Domain

Assessing structural elements that influence Schiff base stability: mutants E113Q and D190N destabilize rhodopsin through different mechanisms

A Novel Non-Covalent Modulator of Hemoglobin Improves Anemia and Reduces Sickling in a Mouse Model of Sickle Cell Disease

Decay of an Active GPCR: Conformational Dynamics Govern Agonist Rebinding and Persistence of an Active, Yet Empty, Rhodopsin State

Monitoring Conformational Changes During Agonist Release from a GPCR in Real Time: Transmembrane Helix 6 Resets as All-Trans Retinal is Released from Rhodopsin

Translation from SCD Mouse to Man: Chronic Administration of Tucaresol Reduces RBC Sickling and Improves Hematological Parameters, but Does Not Impact Inflammatory Markers in SCD Model Mice

CCT5: A Model Protein Folding Machine

Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein

Inter-domain Communication of Human Cystathionine β-Synthase: STRUCTURAL BASIS OF S-ADENOSYL

Crystal Structure of the SH3 Domain of βPIX in Complex with a High Affinity Peptide from PAK2

A Novel Interaction between Atrophin-interacting Protein 4 and Î²-p21-activated Kinase-interactive Exchange Factor Is Mediated by an SH3 Domain

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