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A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

Proceedings of the National Academy of Sciences - PNAS, 2016-09, Vol.113 (37), p.E5511-E5518

2016

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Simultaneous Transdermal Delivery of Buprenorphine Hydrochloride and Naltrexone Hydrochloride by Iontophoresis

Molecular pharmaceutics, 2019-06, Vol.16 (6), p.2808-2816

2019

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Analysis of synthetic cannabinoid agonists and their degradation products after combustion in a smoking simulator

Analytical methods, 2019-06, Vol.11 (24), p.311-317

2019

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The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward

The Journal of pharmacology and experimental therapeutics, 2011-03, Vol.336 (3), p.952

2011

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Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice

European journal of pharmacology, 2015-10, Vol.765, p.582-590

2015

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Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer

Organic & biomolecular chemistry, 2011-05, Vol.9 (9), p.3313-3319

2011

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Targeting opioid receptor signaling in depression: do we need selective κ opioid receptor antagonists?

Neuronal signaling, 2018-06, Vol.2 (2), p.NS20170145-NS20170145

2018

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Structural Determinants of Opioid and NOP Receptor Activity in Derivatives of Buprenorphine

Journal of medicinal chemistry, 2011-10, Vol.54 (19), p.6531-6537

2011

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Structural insights into µ-opioid receptor activation

Nature (London), 2015-08, Vol.524 (7565), p.315-321

2015

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Long‐term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox

Pharmacology research & perspectives, 2021-12, Vol.9 (6), p.e00887-n/a

2021

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Additive Effects of 3,4-Methylenedioxymethamphetamine (MDMA) and Compassionate Imagery on Self-Compassion in Recreational Users of Ecstasy

Mindfulness, 2018-08, Vol.9 (4), p.1134-1145

2018

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Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-Dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline2 binding site

Synapse (New York, N.Y.), 2012-06, Vol.66 (6), p.542-551

2012

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Methocinnamox (MCAM) antagonizes the behavioral suppressant effects of morphine without impairing delayed matching-to-sample accuracy in rhesus monkeys

Psychopharmacology, 2020-10, Vol.237 (10), p.3057-3065

2020

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PPL-138 (BU10038): A bifunctional NOP/mu partial agonist that reduces cocaine self-administration in rats

Neuropharmacology, 2022-06, Vol.211, p.109045-109045, Article 109045

2022

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Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile

Frontiers in psychiatry, 2018-09, Vol.9, p.430-430

2018

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Pleiotropic Effects of Kappa Opioid Receptor-Related Ligands in Non-human Primates

Handbook of experimental pharmacology, 2022, Vol.271, p.435-452

2022

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Effects of sex and hydration status on kappa opioid receptor‐mediated diuresis in rats

Basic & clinical pharmacology & toxicology, 2024-06, Vol.134 (6), p.792-804

2024

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Antidepressant‐like effects of BU10119, a novel buprenorphine analogue with mixed κ/μ receptor antagonist properties, in mice

British journal of pharmacology, 2018-07, Vol.175 (14), p.2869-2880

2018

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Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys

Neuropsychopharmacology (New York, N.Y.), 2020-11, Vol.45 (12), p.1986-1993

2020

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Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice

Journal of psychopharmacology (Oxford), 2015-07, Vol.29 (7), p.812-821

2015

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A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase

British journal of pharmacology, 2023-04, Vol.180 (7), p.943-957

2023

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BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates

British journal of anaesthesia : BJA, 2019-06, Vol.122 (6), p.e146-e156

2019

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The Buprenorphine Analogue BU10119 Attenuates Drug-Primed and Stress-Induced Cocaine Reinstatement in Mice

The Journal of pharmacology and experimental therapeutics, 2021-09, Vol.378 (3), p.287

2021

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H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

Analytical methods, 2019-10, Vol.11 (37), p.4795-487

2019

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Countermeasures for Preventing and Treating Opioid Overdose

Clinical pharmacology and therapeutics, 2021-03, Vol.109 (3), p.578-590

2021

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A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

Simultaneous Transdermal Delivery of Buprenorphine Hydrochloride and Naltrexone Hydrochloride by Iontophoresis

Analysis of synthetic cannabinoid agonists and their degradation products after combustion in a smoking simulator

The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward

Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice

Microfluidic reactions using [11C]carbon monoxide solutions for the synthesis of a positron emission tomography radiotracer

Targeting opioid receptor signaling in depression: do we need selective κ opioid receptor antagonists?

Structural Determinants of Opioid and NOP Receptor Activity in Derivatives of Buprenorphine

Structural insights into µ-opioid receptor activation

Long‐term antagonism and allosteric regulation of mu opioid receptors by the novel ligand, methocinnamox

Additive Effects of 3,4-Methylenedioxymethamphetamine (MDMA) and Compassionate Imagery on Self-Compassion in Recreational Users of Ecstasy

Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-Dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline2 binding site

Methocinnamox (MCAM) antagonizes the behavioral suppressant effects of morphine without impairing delayed matching-to-sample accuracy in rhesus monkeys

PPL-138 (BU10038): A bifunctional NOP/mu partial agonist that reduces cocaine self-administration in rats

Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile

Pleiotropic Effects of Kappa Opioid Receptor-Related Ligands in Non-human Primates

Effects of sex and hydration status on kappa opioid receptor‐mediated diuresis in rats

Antidepressant‐like effects of BU10119, a novel buprenorphine analogue with mixed κ/μ receptor antagonist properties, in mice

Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys

Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice

A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates

The Buprenorphine Analogue BU10119 Attenuates Drug-Primed and Stress-Induced Cocaine Reinstatement in Mice

H quantitative NMR and UHPLC-MS analysis of seized MDMA/NPS mixtures and tablets from night-club venues

Countermeasures for Preventing and Treating Opioid Overdose

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