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Targeted Therapy and Checkpoint Immunotherapy Combinations for the Treatment of Cancer

Trends in immunology, 2016-07, Vol.37 (7), p.462-476

2016

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In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

Molecular cancer therapeutics, 2016-07, Vol.15 (7), p.1568-1579

2016

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Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics

Blood cancer journal (New York), 2023-04, Vol.13 (1), p.57-57, Article 57

2023

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Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics

Blood cancer journal (New York), 2023-05, Vol.13 (1), p.80-80, Article 80

2023

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AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer

Clinical cancer research, 2021-03, Vol.27 (5), p.1526-1537

2021

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Provision Point-Source Materials Stimulates Play in Sows but Does Not Affect Aggression at Regrouping

Animals (Basel), 2018-12, Vol.9 (1), p.8

2018

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Mixing Sows into Alternative Lactation Housing Affects Sow Aggression at Mixing, Future Reproduction and Piglet Injury, with Marked Differences between Multisuckle and Sow Separation Systems

Animals (Basel), 2019-09, Vol.9 (9), p.658

2019

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Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.611-626

2007

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Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

Cell, 1997-02, Vol.88 (4), p.521-530

1997

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Complementation of dominant suppression implicates CD98 in integrin activation

Nature (London), 1997-11, Vol.390 (6655), p.81-85

1997

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Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition

The EMBO journal, 2024-03, Vol.43 (5), p.666-694

2024

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Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic-Resistant AML and AML Stem Cells

Molecular cancer therapeutics, 2022-06, Vol.21 (6), p.879-889

2022

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Discovery and in Vivo Evaluation of Macrocyclic Mcl‑1 Inhibitors Featuring an α‑Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere

Journal of medicinal chemistry, 2019-11, Vol.62 (22), p.10258-10271

2019

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MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor

Oncotarget, 2017-03, Vol.8 (11), p.17795-17809

2017

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Integrin affinity modulation

Trends in cell biology, 1998-09, Vol.8 (9), p.359-364

1998

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Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors

Journal of experimental & clinical cancer research, 2010-07, Vol.29 (1), p.96-96, Article 96

2010

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Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat

Brain research, 1999-07, Vol.835 (2), p.369-378

1999

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Integrin Activation Controls Metastasis in Human Breast Cancer

Proceedings of the National Academy of Sciences - PNAS, 2001-02, Vol.98 (4), p.1853-1858

2001

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Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors

Bioorganic & medicinal chemistry letters, 2007-05, Vol.17 (10), p.2886-2889

2007

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The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (19), p.4136-4142

2015

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Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure–Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4735-4751

2011

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Controlling lactation oestrus: The final frontier for breeding herd management

Molecular reproduction and development, 2017-09, Vol.84 (9), p.883-896

2017

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MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways

Oncotarget, 2014-04, Vol.5 (8), p.2030-2043

2014

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Targeted Therapy and Checkpoint Immunotherapy Combinations for the Treatment of Cancer

In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models

Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics

Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics

AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies

Provision Point-Source Materials Stimulates Play in Sows but Does Not Affect Aggression at Regrouping

Mixing Sows into Alternative Lactation Housing Affects Sow Aggression at Mixing, Future Reproduction and Piglet Injury, with Marked Differences between Multisuckle and Sow Separation Systems

Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor

Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway

Complementation of dominant suppression implicates CD98 in integrin activation

Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition

Maximal Activation of Apoptosis Signaling by Cotargeting Antiapoptotic Proteins in BH3 Mimetic-Resistant AML and AML Stem Cells

Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS -Mutant Non-Small Cell Lung Cancer

Discovery and in Vivo Evaluation of Macrocyclic Mcl‑1 Inhibitors Featuring an α‑Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere

MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor

Integrin affinity modulation

Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors

Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat

Integrin Activation Controls Metastasis in Human Breast Cancer

Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors

The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors

Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure–Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives

Controlling lactation oestrus: The final frontier for breeding herd management

MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways

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