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A general protocol for the generation of Nanobodies for structural biology

Nature protocols, 2014-03, Vol.9 (3), p.674-693

2014

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Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy

PloS one, 2014-03, Vol.9 (3), p.e92929-e92929

2014

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Structural Basis for the Activation of Cholera Toxin by Human ARF6-GTP

Science (American Association for the Advancement of Science), 2005-08, Vol.309 (5737), p.1093-1096

2005

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Structural and functional studies on the interaction of GspC and GspD in the type II secretion system

PLoS pathogens, 2011-09, Vol.7 (9), p.e1002228-e1002228

2011

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In vivo cross-linking of EpsG to EpsL suggests a role for EpsL as an ATPase-pseudopilin coupling protein in the Type II secretion system of Vibrio cholerae

Molecular microbiology, 2011-02, Vol.79 (3), p.786-798

2011

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Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice

Antimicrobial Agents and Chemotherapy, 2011-05, Vol.55 (5), p.1982-1989

2011

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Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites

Antimicrobial agents and chemotherapy, 2015-11, Vol.59 (11), p.7128-7131

2015

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Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

Science (American Association for the Advancement of Science), 1998-03, Vol.279 (5356), p.1504-1513

1998

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Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1

Journal of medicinal chemistry, 2012-03, Vol.55 (6), p.2803-2810

2012

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Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness

PLoS neglected tropical diseases, 2014-04, Vol.8 (4), p.e2775

2014

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Structure of the cholera toxin secretion channel in its closed state

Nature structural & molecular biology, 2010-10, Vol.17 (10), p.1226

2010

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Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.3021-3028

2013

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A Model for the Mechanism of Human Topoisomerase I

Science (American Association for the Advancement of Science), 1998-03, Vol.279 (5356), p.1534-1541

1998

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Structure of the GspK-GspI-GspJ complex from the enterotoxigenic Escherichia coli type 2 secretion system

Nature structural & molecular biology, 2008-05, Vol.15 (5), p.462-468

2008

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Calcium Is Essential for the Major Pseudopilin in the Type 2 Secretion System

The Journal of biological chemistry, 2009-09, Vol.284 (38), p.25466-25470

2009

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Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Molecular microbiology, 2008-04, Vol.68 (1), p.37-50

2008

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Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection

Antimicrobial agents and chemotherapy, 2019-04, Vol.63 (4)

2019

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Synergistic stimulation of EpsE ATP hydrolysis by EpsL and acidic phospholipids

The EMBO journal, 2007-01, Vol.26 (1), p.19-27

2007

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The role of medical structural genomics in discovering new drugs for infectious diseases

PLoS computational biology, 2009-10, Vol.5 (10), p.e1000530-e1000530

2009

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Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite

Proceedings of the National Academy of Sciences - PNAS, 2007-04, Vol.104 (17), p.7015-7020

2007

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Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections

Antimicrobial agents and chemotherapy, 2017-11, Vol.61 (11)

2017

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Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

Nature structural & molecular biology, 2010-05, Vol.17 (5), p.602

2010

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The type II secretion system: biogenesis, molecular architecture and mechanism

Nature reviews. Microbiology, 2012-05, Vol.10 (5), p.336-351

2012

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Characterization and Crystal Structure of a High-Affinity Pentavalent Receptor-Binding Inhibitor for Cholera Toxin and E. coli Heat-Labile Enterotoxin

Journal of the American Chemical Society, 2002-07, Vol.124 (30), p.8818-8824

2002

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A general protocol for the generation of Nanobodies for structural biology

Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy

Structural Basis for the Activation of Cholera Toxin by Human ARF6-GTP

Structural and functional studies on the interaction of GspC and GspD in the type II secretion system

In vivo cross-linking of EpsG to EpsL suggests a role for EpsL as an ATPase-pseudopilin coupling protein in the Type II secretion system of Vibrio cholerae

Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice

Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites

Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1

Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness

Structure of the cholera toxin secretion channel in its closed state

Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target

A Model for the Mechanism of Human Topoisomerase I

Structure of the GspK-GspI-GspJ complex from the enterotoxigenic Escherichia coli type 2 secretion system

Calcium Is Essential for the Major Pseudopilin in the Type 2 Secretion System

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection

Synergistic stimulation of EpsE ATP hydrolysis by EpsL and acidic phospholipids

The role of medical structural genomics in discovering new drugs for infectious diseases

Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite

Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

The type II secretion system: biogenesis, molecular architecture and mechanism

Characterization and Crystal Structure of a High-Affinity Pentavalent Receptor-Binding Inhibitor for Cholera Toxin and E. coli Heat-Labile Enterotoxin

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