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The Tryp and the Pendulum

EBioMedicine, 2021-02, Vol.64, p.103188-103188, Article 103188

Buckner, Frederick S.

2021

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Synergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruzi

PLoS neglected tropical diseases, 2014-07, Vol.8 (7), p.e2977

2014

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Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1639-1647

2009

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Bioisosteric Transformations and Permutations in the Triazolopyrimidine Scaffold To Identify the Minimum Pharmacophore Required for Inhibitory Activity against Plasmodium falciparum Dihydroorotate Dehydrogenase

Journal of medicinal chemistry, 2012-09, Vol.55 (17), p.7425-7436

2012

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Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection

Structure (London), 2012-10, Vol.20 (10), p.1681-1691

2012

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Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

PloS one, 2016-08, Vol.11 (8), p.e0160350

2016

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Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

Antimicrobial Agents and Chemotherapy, 2012-09, Vol.56 (9), p.4914-4921

2012

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Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice

Antimicrobial Agents and Chemotherapy, 2011-05, Vol.55 (5), p.1982-1989

2011

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Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni

Frontiers in cellular and infection microbiology, 2019-05, Vol.9, p.180-180

2019

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Phenotypic drug discovery for human African trypanosomiasis: A powerful approach

Tropical medicine and infectious disease, 2020-03, Vol.5 (1), p.1-18

2020

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Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness

PLoS neglected tropical diseases, 2014-04, Vol.8 (4), p.e2775

2014

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Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target

Antimicrobial Agents and Chemotherapy, 2013-07, Vol.57 (7), p.3021-3028

2013

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Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy

Antimicrobial Agents and Chemotherapy, 2008-10, Vol.52 (10), p.3710-3717

2008

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Heterologous expression of proteins from Plasmodium falciparum: Results from 1000 genes

Molecular and biochemical parasitology, 2006-08, Vol.148 (2), p.144-160

2006

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Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

PloS one, 2016-09, Vol.11 (9), p.e0163641-e0163641

2016

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Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington

Clinical infectious diseases, 2020-11, Vol.71 (16), p.2167-2173

2020

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Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Molecular microbiology, 2008-04, Vol.68 (1), p.37-50

2008

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An essential farnesylated kinesin in Trypanosoma brucei

PloS one, 2011-11, Vol.6 (11), p.e26508-e26508

2011

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Case Report: Miltefosine Failure and Spontaneous Resolution of Cutaneous Leishmaniasis braziliensis

The American journal of tropical medicine and hygiene, 2021-07, Vol.105 (1), p.142-143

2021

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Advances in Chagas disease drug development: 2009–2010

Current opinion in infectious diseases, 2010-12, Vol.23 (6), p.609-616

2010

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Recent developments in sterol 14-demethylase inhibitors for Chagas disease

International journal for parasitology -- drugs and drug resistance, 2012-12, Vol.2, p.236-242

2012

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Using Fragment Cocktail Crystallography To Assist Inhibitor Design of Trypanosoma brucei Nucleoside 2-Deoxyribosyltransferase

Journal of medicinal chemistry, 2006-10, Vol.49 (20), p.5939-5946

2006

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Urea Derivatives of 2‑Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis

Journal of medicinal chemistry, 2017-02, Vol.60 (3), p.957-971

2017

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Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice

Journal of medicinal chemistry, 2009-04, Vol.52 (7), p.1864-1872

2009

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The Tryp and the Pendulum

Synergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruzi

Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease

Bioisosteric Transformations and Permutations in the Triazolopyrimidine Scaffold To Identify the Minimum Pharmacophore Required for Inhibitory Activity against Plasmodium falciparum Dihydroorotate Dehydrogenase

Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection

Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

Selective Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Trypanosoma brucei Infection in Mice

Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni

Phenotypic drug discovery for human African trypanosomiasis: A powerful approach

Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness

Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target

Glycogen Synthase Kinase 3 Is a Potential Drug Target for African Trypanosomiasis Therapy

Heterologous expression of proteins from Plasmodium falciparum: Results from 1000 genes

Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

An essential farnesylated kinesin in Trypanosoma brucei

Case Report: Miltefosine Failure and Spontaneous Resolution of Cutaneous Leishmaniasis braziliensis

Advances in Chagas disease drug development: 2009–2010

Recent developments in sterol 14-demethylase inhibitors for Chagas disease

Using Fragment Cocktail Crystallography To Assist Inhibitor Design of Trypanosoma brucei Nucleoside 2-Deoxyribosyltransferase

Urea Derivatives of 2‑Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis

Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice

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