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The TLR4 antagonist Eritoran protects mice from lethal influenza infection

Nature (London), 2013-05, Vol.497 (7450), p.498-502

2013

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Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

Nature, 2009-01, Vol.457 (7229), p.585-588

2009

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Isolation of an Endotoxin-MD-2 Complex That Produces Toll-Like Receptor 4-Dependent Cell Activation at Picomolar Concentrations

Proceedings of the National Academy of Sciences - PNAS, 2004-03, Vol.101 (12), p.4186-4191

2004

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Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin

The Journal of biological chemistry, 2009-05, Vol.284 (22), p.15052-15060

2009

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Expression of Functional D299G.T399I Polymorphic Variant of TLR4 Depends More on Coexpression of MD-2 Than Does Wild-Type TLR4

The Journal of immunology (1950), 2010-04, Vol.184 (8), p.4362-4367

2010

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Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2

mBio, 2012, Vol.3 (4)

2012

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Tetraacylated lipid A and paclitaxel-selective activation of TLR4/MD-2 conferred through hydrophobic interactions

The Journal of immunology (1950), 2014-02, Vol.192 (4), p.1887-1895

2014

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Endotoxin·albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of TLR4

Innate immunity (London, England), 2012-06, Vol.18 (3), p.478-491

2012

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Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2

American journal of physiology. Lung cellular and molecular physiology, 2004-08, Vol.287 (2), p.L428-L437

2004

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Novel Roles in Human MD-2 of Phenylalanines 121 and 126 and Tyrosine 131 in Activation of Toll-like Receptor 4 by Endotoxin

The Journal of biological chemistry, 2008-01, Vol.283 (3), p.1257-1266

2008

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Novel Roles of Lysines 122, 125, and 58 in Functional Differences between Human and Murine MD-2

The Journal of immunology (1950), 2009-10, Vol.183 (8), p.5138-5145

2009

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An Essential Role for Albumin in the Interaction of Endotoxin with Lipopolysaccharide-binding Protein and sCD14 and Resultant Cell Activation

The Journal of biological chemistry, 2002-12, Vol.277 (49), p.47818-47825

2002

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Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells

Immunologic research, 2007-11, Vol.39 (1-3), p.249-260

2007

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The role of MicroRNAs miR-200b and miR-200c in TLR4 signaling and NF-κB activation

Innate immunity (London, England), 2012-12, Vol.18 (6), p.846-855

2012

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Endotoxin-binding Proteins Modulate the Susceptibility of Bacterial Endotoxin to Deacylation by Acyloxyacyl Hydrolase

The Journal of biological chemistry, 2007-03, Vol.282 (11), p.7877-7884

2007

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NMR Studies of Hexaacylated Endotoxin Bound to Wild-type and F126A Mutant MD-2 and MD-2·TLR4 Ectodomain Complexes

The Journal of biological chemistry, 2012-05, Vol.287 (20), p.16346-16355

2012

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Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins

Immunologic research, 2014-08, Vol.59 (1-3), p.3-11

2014

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Molecular Basis of the Functional Differences between Soluble Human Versus Murine MD-2: Role of Val135 in Transfer of Lipopolysaccharide from CD14 to MD-2

The Journal of immunology (1950), 2016-03, Vol.196 (5), p.2309-2318

2016

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Molecular Basis of Reduced Potency of Underacylated Endotoxins

Journal of Immunology, 2005-10, Vol.175 (7), p.4669-4676

2005

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Specific High Affinity Interactions of Monomeric Endotoxin·Protein Complexes with Toll-like Receptor 4 Ectodomain

The Journal of biological chemistry, 2007-01, Vol.282 (2), p.1010-1017

2007

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Radioiodination of an endotoxin·MD-2 complex generates a novel sensitive, high-affinity ligand for TLR4

Innate immunity (London, England), 2013-10, Vol.19 (5), p.545-560

2013

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Isolation of Monomeric and Dimeric Secreted MD-2: ENDOTOXIN·sCD14 AND TOLL-LIKE RECEPTOR 4 ECTODOMAIN SELECTIVELY REACT WITH THE MONOMERIC FORM OF SECRETED MD-2

The Journal of biological chemistry, 2008-08, Vol.283 (32), p.21881-21889

2008

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Isolation of monomeric and dimeric secreted MD-2. Endotoxin.sCD14 and Toll-like receptor 4 ectodomain selectively react with the monomeric form of secreted MD-2

The Journal of biological chemistry, 2008-08, Vol.283 (32), p.21881-21889

2008

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Endotoxin.albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of TLR4

Innate immunity (London, England), 2012-06, Vol.18 (3), p.478-491

2012

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A Novel Role for the Bactericidal/Permeability Increasing Protein in Interactions of Gram-Negative Bacterial Outer Membrane Blebs with Dendritic Cells

Journal of Immunology, 2007-08, Vol.179 (4), p.2477-2484

2007

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The TLR4 antagonist Eritoran protects mice from lethal influenza infection

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

Isolation of an Endotoxin-MD-2 Complex That Produces Toll-Like Receptor 4-Dependent Cell Activation at Picomolar Concentrations

Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin

Expression of Functional D299G.T399I Polymorphic Variant of TLR4 Depends More on Coexpression of MD-2 Than Does Wild-Type TLR4

Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2

Tetraacylated lipid A and paclitaxel-selective activation of TLR4/MD-2 conferred through hydrophobic interactions

Endotoxin·albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of TLR4

Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2

Novel Roles in Human MD-2 of Phenylalanines 121 and 126 and Tyrosine 131 in Activation of Toll-like Receptor 4 by Endotoxin

Novel Roles of Lysines 122, 125, and 58 in Functional Differences between Human and Murine MD-2

An Essential Role for Albumin in the Interaction of Endotoxin with Lipopolysaccharide-binding Protein and sCD14 and Resultant Cell Activation

Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells

The role of MicroRNAs miR-200b and miR-200c in TLR4 signaling and NF-κB activation

Endotoxin-binding Proteins Modulate the Susceptibility of Bacterial Endotoxin to Deacylation by Acyloxyacyl Hydrolase

NMR Studies of Hexaacylated Endotoxin Bound to Wild-type and F126A Mutant MD-2 and MD-2·TLR4 Ectodomain Complexes

Purified monomeric ligand.MD-2 complexes reveal molecular and structural requirements for activation and antagonism of TLR4 by Gram-negative bacterial endotoxins

Molecular Basis of the Functional Differences between Soluble Human Versus Murine MD-2: Role of Val135 in Transfer of Lipopolysaccharide from CD14 to MD-2

Molecular Basis of Reduced Potency of Underacylated Endotoxins

Specific High Affinity Interactions of Monomeric Endotoxin·Protein Complexes with Toll-like Receptor 4 Ectodomain

Radioiodination of an endotoxin·MD-2 complex generates a novel sensitive, high-affinity ligand for TLR4

Isolation of Monomeric and Dimeric Secreted MD-2: ENDOTOXIN·sCD14 AND TOLL-LIKE RECEPTOR 4 ECTODOMAIN SELECTIVELY REACT WITH THE MONOMERIC FORM OF SECRETED MD-2

Isolation of monomeric and dimeric secreted MD-2. Endotoxin.sCD14 and Toll-like receptor 4 ectodomain selectively react with the monomeric form of secreted MD-2

Endotoxin.albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of TLR4

A Novel Role for the Bactericidal/Permeability Increasing Protein in Interactions of Gram-Negative Bacterial Outer Membrane Blebs with Dendritic Cells

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