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Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (26), p.10830-10835

2013

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A novel small molecule inhibitor of hepatitis C virus entry

PLoS pathogens, 2010-09, Vol.6 (9), p.e1001086

2010

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Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: Development of chemical probe ML315

Bioorganic & medicinal chemistry letters, 2013-06, Vol.23 (12), p.3654-3661

2013

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Influenza Nucleoprotein: Promising Target for Antiviral Chemotherapy

Antiviral Chemistry and Chemotherapy, 2013-06, Vol.23 (3), p.77-91

2013

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Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV‑1 Integrase Inhibitors

Journal of medicinal chemistry, 2020-03, Vol.63 (5), p.2620-2637

2020

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High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus

PloS one, 2012-08, Vol.7 (8), p.e42609-e42609

2012

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Identification and biochemical analyses of selective CB2 agonists

European journal of pharmacology, 2019-07, Vol.854, p.1-8

2019

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Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ‑Opioid Receptor

Journal of medicinal chemistry, 2015-05, Vol.58 (10), p.4220-4229

2015

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Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ‑Opioid Receptor

Journal of chemical information and modeling, 2015-09, Vol.55 (9), p.1836-1843

2015

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An efficient one-pot synthesis of 3-aryl-5-methylisoxazoles from aryl aldehydes

Tetrahedron letters, 2011-08, Vol.52 (31), p.4001-4004

2011

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A fast and efficient bromination of isoxazoles and pyrazoles by microwave irradiation

Tetrahedron letters, 2007-06, Vol.48 (26), p.4595-4599

2007

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Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9208-9223

2012

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Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

Bioorganic & medicinal chemistry letters, 2015-11, Vol.25 (22), p.5040-5047

2015

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Solid phase synthesis of 1,5-disubstituted pyrazole-4-hydroxamic acids and pyrazole-4-carboxamides via direct amidation of β-ketoesters

Tetrahedron letters, 2012-01, Vol.53 (3), p.267-270

2012

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Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging

SLAS discovery, 2021-02, Vol.26 (2), p.242-247

2021

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Small Molecule Receptor Protein Tyrosine Phosphatase γ (RPTPγ) Ligands That Inhibit Phosphatase Activity via Perturbation of the Tryptophan–Proline–Aspartate (WPD) Loop

Journal of medicinal chemistry, 2011-10, Vol.54 (19), p.6548-6562

2011

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Discovery of Selective Cannabinoid CB2 Receptor Agonists by High-Throughput Screening

SLAS discovery, 2018-04, Vol.23 (4), p.375-383

2018

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Two General Routes to 1,4-Disubstituted-2,3,4,5-tetrahydro- 1H-3-benzazepines

Organic letters, 2000-12, Vol.2 (25), p.4099-4102

2000

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Solid Phase Synthesis of 1,5-Diarylpyrazole-4-carboxamides: Discovery of Antagonists of the CB-1 Receptor

ACS combinatorial science, 2012-03, Vol.14 (3), p.197-204

2012

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Discovery of pyrazine carboxamide CB1 antagonists: The introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series

Bioorganic & medicinal chemistry letters, 2007-07, Vol.17 (14), p.3978-3982

2007

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Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (22), p.6477-6480

2009

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A high-throughput screen for receptor protein tyrosine phosphatase-gamma selective inhibitors

Journal of biomolecular screening, 2011-06, Vol.16 (5), p.476-485

2011

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Discovery and optimization of ( R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR)

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (18), p.5083-5086

2008

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Quantitative techniques for the comparison of solid supports

Current Opinion in Chemical Biology, 2001-06, Vol.5 (3), p.264-268

Gerritz, Samuel W

2001

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Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor

A novel small molecule inhibitor of hepatitis C virus entry

Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: Development of chemical probe ML315

Influenza Nucleoprotein: Promising Target for Antiviral Chemotherapy

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV‑1 Integrase Inhibitors

Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies

High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus

Identification and biochemical analyses of selective CB2 agonists

Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ‑Opioid Receptor

Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ‑Opioid Receptor

An efficient one-pot synthesis of 3-aryl-5-methylisoxazoles from aryl aldehydes

A fast and efficient bromination of isoxazoles and pyrazoles by microwave irradiation

Acyl Guanidine Inhibitors of β‑Secretase (BACE-1): Optimization of a Micromolar Hit to a Nanomolar Lead via Iterative Solid- and Solution-Phase Library Synthesis

Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE)

Solid phase synthesis of 1,5-disubstituted pyrazole-4-hydroxamic acids and pyrazole-4-carboxamides via direct amidation of β-ketoesters

Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging

Small Molecule Receptor Protein Tyrosine Phosphatase γ (RPTPγ) Ligands That Inhibit Phosphatase Activity via Perturbation of the Tryptophan–Proline–Aspartate (WPD) Loop

Discovery of Selective Cannabinoid CB2 Receptor Agonists by High-Throughput Screening

Two General Routes to 1,4-Disubstituted-2,3,4,5-tetrahydro- 1H-3-benzazepines

Solid Phase Synthesis of 1,5-Diarylpyrazole-4-carboxamides: Discovery of Antagonists of the CB-1 Receptor

Discovery of pyrazine carboxamide CB1 antagonists: The introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series

Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors

A high-throughput screen for receptor protein tyrosine phosphatase-gamma selective inhibitors

Discovery and optimization of ( R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR)

Quantitative techniques for the comparison of solid supports

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