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Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

Cell, 2015-03, Vol.160 (6), p.1196-1208

2015

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Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (26), p.10830-10835

2013

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Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

The Journal of biological chemistry, 2013-12, Vol.288 (49), p.35039-35048

2013

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Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling

Cell, 2017-03, Vol.168 (6), p.1041-1052.e18

2017

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Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

eLife, 2017-05, Vol.6

2017

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novel enzyme complementation-based assay for monitoring G-protein-coupled receptor internalization

The FASEB journal, 2007-12, Vol.21 (14), p.3827-3834

2007

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Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors

Journal of biomolecular screening, 2013-06, Vol.18 (5), p.599-609

2013

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Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ‑Opioid Receptor

Journal of medicinal chemistry, 2015-05, Vol.58 (10), p.4220-4229

2015

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Restriction enzyme-generated siRNA (REGS) vectors and libraries

Nature genetics, 2004-02, Vol.36 (2), p.183-189

2004

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Enzymatic detection of protein translocation

Nature methods, 2005-07, Vol.2 (7), p.521-527

2005

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universal technology for monitoring G-protein-coupled receptor activation in vitro and noninvasively in live animals

The FASEB journal, 2007-12, Vol.21 (14), p.3819-3826

2007

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Measurements of β-arrestin recruitment to activated seven transmembrane receptors using enzyme complementation

Methods in molecular biology (Clifton, N.J.), 2012, Vol.897, p.181

2012

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Pathway Phenotyping of B-Cell Receptor Activation and Inhibition: Translation to Novel Clinical Biomarkers

Blood, 2014-12, Vol.124 (21), p.5962-5962

Wehrman, Tom S

2014

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Characterization of G-protein coupled receptor modulators using homogeneous cAMP assays

Methods in molecular biology (Clifton, N.J.), 2012, Vol.897, p.171

2012

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Imaging beta-galactosidase activity in vivo using sequential reporter-enzyme luminescence

Methods in molecular biology (Clifton, N.J.), 2009, Vol.574, p.249

2009

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mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage

Differentiation (London), 2005-07, Vol.73 (6), p.287-293

2005

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Defining the Cell Surface Landscape in B-Cell Malignancies: Comprehensive Profiling of Surface Antigens for Biomarker Discovery and Patient Stratification

Blood, 2014-12, Vol.124 (21), p.5183-5183

2014

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Abstract 5385: A novel cell-based kinase assay panel paired with high content phenotypic profiling to correlate kinase inhibitor specificity and cellular activity

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.5385-5385

2014

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Abstract 2496: Defining the cell surface landscape in cancer: Comprehensive profiling of surface antigens for biomarker discovery and immune monitoring

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.2496-2496

2014

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Discovery of positive allosteric modulators and silent allosteric modulators of the [mu]-opioid receptor

Proceedings of the National Academy of Sciences - PNAS, 2013-06, Vol.110 (26), p.10830

2013

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Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors

Neuron (Cambridge, Mass.), 2007-01, Vol.53 (1), p.25-38

2007

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Abstract 3036: Intracellular phospho-flow reveals novel insights to pathway modulation by tirabrutinib in combination with entospletinib and obinutuzumab

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.3036-3036

2020

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Protein-Protein Interactions Monitored in Mammalian Cells via Complementation of β-Lactamase Enzyme Fragments

Proceedings of the National Academy of Sciences - PNAS, 2002-03, Vol.99 (6), p.3469-3474

2002

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Identification of selective agonists and positive allosteric modulators for µ- and δ-opioid receptors from a single high-throughput screen

Journal of biomolecular screening, 2014-10, Vol.19 (9), p.1255-1265

2014

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Understanding the mechanism of biased agonism at chemokine receptors (1066.17)

The FASEB journal, 2014-04, Vol.28 (S1), p.n/a

2014

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Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands

Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor

Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

novel enzyme complementation-based assay for monitoring G-protein-coupled receptor internalization

Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors

Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ‑Opioid Receptor

Restriction enzyme-generated siRNA (REGS) vectors and libraries

Enzymatic detection of protein translocation

universal technology for monitoring G-protein-coupled receptor activation in vitro and noninvasively in live animals

Measurements of β-arrestin recruitment to activated seven transmembrane receptors using enzyme complementation

Pathway Phenotyping of B-Cell Receptor Activation and Inhibition: Translation to Novel Clinical Biomarkers

Characterization of G-protein coupled receptor modulators using homogeneous cAMP assays

Imaging beta-galactosidase activity in vivo using sequential reporter-enzyme luminescence

mRNA translation is not a prerequisite for small interfering RNA-mediated mRNA cleavage

Defining the Cell Surface Landscape in B-Cell Malignancies: Comprehensive Profiling of Surface Antigens for Biomarker Discovery and Patient Stratification

Abstract 5385: A novel cell-based kinase assay panel paired with high content phenotypic profiling to correlate kinase inhibitor specificity and cellular activity

Abstract 2496: Defining the cell surface landscape in cancer: Comprehensive profiling of surface antigens for biomarker discovery and immune monitoring

Discovery of positive allosteric modulators and silent allosteric modulators of the [mu]-opioid receptor

Structural and Mechanistic Insights into Nerve Growth Factor Interactions with the TrkA and p75 Receptors

Abstract 3036: Intracellular phospho-flow reveals novel insights to pathway modulation by tirabrutinib in combination with entospletinib and obinutuzumab

Protein-Protein Interactions Monitored in Mammalian Cells via Complementation of β-Lactamase Enzyme Fragments

Identification of selective agonists and positive allosteric modulators for µ- and δ-opioid receptors from a single high-throughput screen

Understanding the mechanism of biased agonism at chemokine receptors (1066.17)

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