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Apoptosis-inducing factor: vital and lethal

Trends in cell biology, 2006-05, Vol.16 (5), p.264-272

2006

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Structural basis of AMPK regulation by small molecule activators

Nature communications, 2013-12, Vol.4 (1), p.3017-3017, Article 3017

2013

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Stabilization of protein–protein interactions by small molecules

Drug discovery today, 2014-11, Vol.19 (11), p.1812-1821

2014

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Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

Journal of medicinal chemistry, 2014-01, Vol.57 (2), p.278-295

2014

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Early Drug Development: Bringing a Preclinical Candidate to the Clinic

1, 2018

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Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective

Drug discovery today, 2015-11, Vol.20 (11), p.1310-1316

2015

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High-Throughput Screening of Drug−Brain Tissue Binding and in Silico Prediction for Assessment of Central Nervous System Drug Delivery

Journal of medicinal chemistry, 2007-09, Vol.50 (19), p.4606-4615

2007

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A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

Molecules (Basel, Switzerland), 2018-10, Vol.23 (10), p.2545

2018

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AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis

Oncogene, 2004-02, Vol.23 (8), p.1514-1521

2004

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On Evaluating Molecular-Docking Methods for Pose Prediction and Enrichment Factors

Journal of chemical information and modeling, 2006-01, Vol.46 (1), p.401-415

2006

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Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2746-2754

2014

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Structure-Based Discovery of Allosteric Modulators of Two Related Class B G-Protein-Coupled Receptors

ChemMedChem, 2011-12, Vol.6 (12), p.2159-2169

2011

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2‐Sulfonylpyrimidines Target the Kinesin HSET via Cysteine Alkylation

European journal of organic chemistry, 2019-09, Vol.2019 (31-32), p.5486-5496

2019

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Small molecule inhibitors of ebola virus infection

Drug discovery today, 2015-02, Vol.20 (2), p.277-286

2015

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Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease

ACS medicinal chemistry letters, 2016-10, Vol.7 (10), p.884-889

2016

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Early drug development: from a drug candidate to the clinic

2018

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Lead Optimization of Ethyl 6‑Aminonicotinate Acyl Sulfonamides as Antagonists of the P2Y12 Receptor. Separation of the Antithrombotic Effect and Bleeding for Candidate Drug AZD1283

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.7015-7024

2013

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Dyrk1A Inhibition as Potential Treatment for Alzheimer’S Disease

Future medicinal chemistry, 2016-04, Vol.8 (6), p.681-696

2016

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Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

Chemistry & biology, 2014-09, Vol.21 (9), p.1115-1142

2014

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Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors

Bioorganic & medicinal chemistry letters, 2012-03, Vol.22 (5), p.1944-1948

2012

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Disruption of the PP1/GADD34 complex induces calreticulin exposure

Cell cycle (Georgetown, Tex.), 2009-12, Vol.8 (23), p.3971-3977

2009

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Direct AMP-activated protein kinase activators: a review of evidence from the patent literature

Expert opinion on therapeutic patents, 2012-12, Vol.22 (12), p.1467-1477

2012

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DYRK1A inhibition as potential treatment for Alzheimer's disease

Future medicinal chemistry, 2016-04, Vol.8 (6), p.681-696

2016

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Intramolecular Hydrogen Bond Expectations in Medicinal Chemistry

ACS medicinal chemistry letters, 2017-02, Vol.8 (2), p.139-142

2017

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Fragment Hits: What do They Look Like and How do They Bind?

Journal of medicinal chemistry, 2019-04, Vol.62 (7), p.3381-3394

2019

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Apoptosis-inducing factor: vital and lethal

Structural basis of AMPK regulation by small molecule activators

Stabilization of protein–protein interactions by small molecules

Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?

Early Drug Development: Bringing a Preclinical Candidate to the Clinic

Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective

High-Throughput Screening of Drug−Brain Tissue Binding and in Silico Prediction for Assessment of Central Nervous System Drug Delivery

A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing

AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis

On Evaluating Molecular-Docking Methods for Pose Prediction and Enrichment Factors

Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

Structure-Based Discovery of Allosteric Modulators of Two Related Class B G-Protein-Coupled Receptors

2‐Sulfonylpyrimidines Target the Kinesin HSET via Cysteine Alkylation

Small molecule inhibitors of ebola virus infection

Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease

Early drug development: from a drug candidate to the clinic

Lead Optimization of Ethyl 6‑Aminonicotinate Acyl Sulfonamides as Antagonists of the P2Y12 Receptor. Separation of the Antithrombotic Effect and Bleeding for Candidate Drug AZD1283

Dyrk1A Inhibition as Potential Treatment for Alzheimer’S Disease

Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors

Disruption of the PP1/GADD34 complex induces calreticulin exposure

Direct AMP-activated protein kinase activators: a review of evidence from the patent literature

DYRK1A inhibition as potential treatment for Alzheimer's disease

Intramolecular Hydrogen Bond Expectations in Medicinal Chemistry

Fragment Hits: What do They Look Like and How do They Bind?

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