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Engineered botulinum neurotoxins as new therapeutics

Annual review of pharmacology and toxicology, 2014-01, Vol.54 (1), p.27-51

2014

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The analgesic potential of clostridial neurotoxin derivatives

Expert opinion on investigational drugs, 2004-11, Vol.13 (11), p.1437-1443

Foster, Keith A

2004

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Engineered toxins: New therapeutics

Toxicon (Oxford), 2009-10, Vol.54 (5), p.587-592

Foster, Keith A.

2009

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Biologics: a new approach needed?

Drug discovery today, 2010-02, Vol.15 (3), p.81-83

Foster, Keith A.

2010

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Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins

Toxicon (Oxford), 2000-02, Vol.38 (2), p.245-258

2000

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A new wrinkle on pain relief: re-engineering clostridial neurotoxins for analgesics

Drug Discovery Today, 2005-04, Vol.10 (8), p.563-569

Foster, Keith A.

2005

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Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A

Protein expression and purification, 2002-07, Vol.25 (2), p.219-228

2002

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Engineering botulinum neurotoxin domains for activation by toxin light chain

The FEBS journal, 2012-02, Vol.279 (3), p.515-523

2012

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Increased levels of SV2A botulinum neurotoxin receptor in clinical sensory disorders and functional effects of botulinum toxins A and E in cultured human sensory neurons

Journal of pain research, 2011, Vol.4 (default), p.347-355

2011

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Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina cristagalli lectin

The Journal of biological chemistry, 2002-09, Vol.277 (38), p.34846-34852

2002

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Botulinum neurotoxin - from laboratory to bedside

Neurotoxicity research, 2006-04, Vol.9 (2-3), p.133-140

2006

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Botulinum Neurotoxin C1 Cleaves both Syntaxin and SNAP-25 in Intact and Permeabilized Chromaffin Cells: Correlation with Its Blockade of Catecholamine Release

Biochemistry (Easton), 1996-02, Vol.35 (8), p.2630-2636

1996

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Retargeted clostridial endopeptidases: Inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain

Movement disorders, 2004-03, Vol.19 (S8), p.S42-S47

2004

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Novel application of an in vitro technique to the detection and quantification of botulinum neurotoxin antibodies

Journal of immunological methods, 2004-05, Vol.288 (1), p.55-60

2004

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Manipulation of Signal Transduction by Botulinum Neurotoxins and their Derivatives

Current signal transduction therapy, 2007-09, Vol.2 (3), p.221-225

2007

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Botulinum Neurotoxin B Inhibits Insulin-Stimulated Glucose Uptake into 3T3-L1 Adipocytes and Cleaves Cellubrevin Unlike Type A Toxin Which Failed To Proteolyze the SNAP-23 Present

Biochemistry (Easton), 1997-05, Vol.36 (19), p.5719-5728

1997

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Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols

Journal of medicinal chemistry, 1991-03, Vol.34 (3), p.919-926

1991

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The Effect of Botulinum Neurotoxins on the Release of Insulin from the Insulinoma Cell Lines HIT-15 and RINm5F

The Journal of biological chemistry, 1995-08, Vol.270 (31), p.18216-18218

1995

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Inhibition of Release of Neurotransmitters from Rat Dorsal Root Ganglia by a Novel Conjugate of a Clostridium botulinumToxin A Endopeptidase Fragment and Erythrina cristagalliLectin

The Journal of biological chemistry, 2002-09, Vol.277 (38), p.34846-34852

2002

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Inhibition of Cyclic Nucleotide Phosphodiesterase by Derivatives of 1,3-Bis(cyclopropylmethyl)xanthine

Journal of medicinal chemistry, 1994-02, Vol.37 (4), p.476-485

1994

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A method for the measurement of [3H]-glutamate release from cultured dorsal root ganglion neurons

Biochemical Society transactions, 1998-05, Vol.26 (2), p.S108-S108

1998

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Synthesis and characterization of tetra-N-alkylated cyclam ligands that contain a functionalized nitrogen substituent

Inorganic chemistry, 1986-12, Vol.25 (26), p.4663-4668

1986

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Re-engineering the target specificity of Clostridial neurotoxins - a route to novel therapeutics

Neurotoxicity research, 2006-04, Vol.9 (2-3), p.101-107

2006

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Inhibition of vesicular secretion in both neuronal and nonneuronal cells by a retargeted endopeptidase derivative of Clostridium botulinum neurotoxin type A

Infection and immunity, 2000-05, Vol.68 (5), p.2587-2593

2000

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Engineered botulinum neurotoxins as new therapeutics

Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2 + DRG sensory neurons

The analgesic potential of clostridial neurotoxin derivatives

Engineered toxins: New therapeutics

Biologics: a new approach needed?

Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins

A new wrinkle on pain relief: re-engineering clostridial neurotoxins for analgesics

Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A

Engineering botulinum neurotoxin domains for activation by toxin light chain

Increased levels of SV2A botulinum neurotoxin receptor in clinical sensory disorders and functional effects of botulinum toxins A and E in cultured human sensory neurons

Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina cristagalli lectin

Botulinum neurotoxin - from laboratory to bedside

Botulinum Neurotoxin C1 Cleaves both Syntaxin and SNAP-25 in Intact and Permeabilized Chromaffin Cells: Correlation with Its Blockade of Catecholamine Release

Retargeted clostridial endopeptidases: Inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain

Novel application of an in vitro technique to the detection and quantification of botulinum neurotoxin antibodies

Manipulation of Signal Transduction by Botulinum Neurotoxins and their Derivatives

Botulinum Neurotoxin B Inhibits Insulin-Stimulated Glucose Uptake into 3T3-L1 Adipocytes and Cleaves Cellubrevin Unlike Type A Toxin Which Failed To Proteolyze the SNAP-23 Present

Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols

The Effect of Botulinum Neurotoxins on the Release of Insulin from the Insulinoma Cell Lines HIT-15 and RINm5F

Inhibition of Release of Neurotransmitters from Rat Dorsal Root Ganglia by a Novel Conjugate of a Clostridium botulinumToxin A Endopeptidase Fragment and Erythrina cristagalliLectin

Inhibition of Cyclic Nucleotide Phosphodiesterase by Derivatives of 1,3-Bis(cyclopropylmethyl)xanthine

A method for the measurement of [3H]-glutamate release from cultured dorsal root ganglion neurons

Synthesis and characterization of tetra-N-alkylated cyclam ligands that contain a functionalized nitrogen substituent

Re-engineering the target specificity of Clostridial neurotoxins - a route to novel therapeutics

Inhibition of vesicular secretion in both neuronal and nonneuronal cells by a retargeted endopeptidase derivative of Clostridium botulinum neurotoxin type A

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