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ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine

Molecular cancer therapeutics, 2020-02, Vol.19 (2), p.325-336

2020

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Abstract 583: The CDK4/6 inhibitor abemaciclib induces synergistic immune activation and antitumor efficacy in combination with PD-L1 blockade

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.583-583

2017

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Abstract 4973: Discovery of LY3214996, a selective and novel ERK1/2 inhibitor with potent antitumor activities in cancer models with MAPK pathway alterations

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.4973-4973

2017

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Abstract 3231: Identifying high quality, potent and selective pyrimidinylthienopyrrolone inhibitors of ERK1/2 kinase: LY3214996

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.3231-3231

2017

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Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1 , HMGCR , or Both

Journal of the American College of Cardiology, 2015-04, Vol.65 (15), p.1552-1561

2015

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Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association

Hypertension (Dallas, Tex. 1979), 2018-11, Vol.72 (5), p.e53-e90

2018

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Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2 × 2 factorial Mendelian randomization study

Journal of the American College of Cardiology, 2015-04, Vol.65 (15), p.1552-1561

2015

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Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cell, 2017-09, Vol.170 (6), p.1079-1095.e20

2017

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The Role of Dietary Protein in Body Weight Regulation among Active-Duty Military Personnel during Energy Deficit: A Systematic Review

Nutrients, 2023-09, Vol.15 (18), p.3948

2023

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A simple ensemble approach for more robust process‐based sensitivity analysis of case studies in convection‐permitting models

Quarterly journal of the Royal Meteorological Society, 2019-10, Vol.145 (724), p.3089-3101

2019

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Recommendations for Improving Integration in National End-to-End Flood Forecasting Systems: An Overview of the FFIR (Flooding From Intense Rainfall) Programme

Water (Basel), 2019-04, Vol.11 (4), p.725

2019

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Exercise increases attentional bias towards food cues in individuals classified as overweight to obese

Physiology & behavior, 2022-04, Vol.247, p.113711-113711, Article 113711

2022

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Convective-Scale Perturbation Growth across the Spectrum of Convective Regimes

Monthly weather review, 2018-01, Vol.146 (1), p.387-405

2018

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Complications in Pediatric Regional Anesthesia: An Analysis of More than 100,000 Blocks from the Pediatric Regional Anesthesia Network

Anesthesiology (Philadelphia), 2018-10, Vol.129 (4), p.721-732

2018

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Staphylococcus aureus Nuclease Is an SaeRS-Dependent Virulence Factor

Infection and Immunity, 2013-04, Vol.81 (4), p.1316-1324

2013

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Characterisation of convective regimes over the British Isles

Quarterly journal of the Royal Meteorological Society, 2016-04, Vol.142 (696), p.1541-1553

2016

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Food-Related Stimuli Impair Inhibitory Control in Adults Classified As Overweight to Obese

Current developments in nutrition, 2022-06, Vol.6 (Supplement_1), p.1046-1046

2022

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Blood pressure treatment and outcomes in hypertensive patients without acute target organ damage: a retrospective cohort

The American journal of emergency medicine, 2015-09, Vol.33 (9), p.1219-1224

2015

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Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling

Clinical cancer research, 2018-12, Vol.24 (23), p.6028-6039

2018

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Generalisable long COVID subtypes: findings from the NIH N3C and RECOVER programmes

EBioMedicine, 2023-01, Vol.87 (C), p.104413-104413, Article 104413

2023

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Characterizing motor impulsivity of individuals classified as overweight to obese

Sports medicine and health science, 2023-12, Vol.5 (4), p.314-318

2023

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Acute Exercise Increases Attentional Bias Towards Food Cues: 1963

Medicine and science in sports and exercise, 2022-09, Vol.54 (9S), p.583-583

2022

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Calorimeter R&D for the SuperNEMO double beta decay experiment

Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment, 2010-11, Vol.623 (1), p.255-257

Flack, Robert

2010

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Gastrointestinal Bleeding With Edoxaban Versus Warfarin: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis In Myocardial Infarction)

Circulation Cardiovascular quality and outcomes, 2018-05, Vol.11 (5), p.e003998-e003998

2018

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ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine

Abstract 583: The CDK4/6 inhibitor abemaciclib induces synergistic immune activation and antitumor efficacy in combination with PD-L1 blockade

Abstract 4973: Discovery of LY3214996, a selective and novel ERK1/2 inhibitor with potent antitumor activities in cancer models with MAPK pathway alterations

Abstract 3231: Identifying high quality, potent and selective pyrimidinylthienopyrrolone inhibitors of ERK1/2 kinase: LY3214996

Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1 , HMGCR , or Both

Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association

Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2 × 2 factorial Mendelian randomization study

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

The Role of Dietary Protein in Body Weight Regulation among Active-Duty Military Personnel during Energy Deficit: A Systematic Review

A simple ensemble approach for more robust process‐based sensitivity analysis of case studies in convection‐permitting models

Recommendations for Improving Integration in National End-to-End Flood Forecasting Systems: An Overview of the FFIR (Flooding From Intense Rainfall) Programme

Exercise increases attentional bias towards food cues in individuals classified as overweight to obese

Convective-Scale Perturbation Growth across the Spectrum of Convective Regimes

Complications in Pediatric Regional Anesthesia: An Analysis of More than 100,000 Blocks from the Pediatric Regional Anesthesia Network

Staphylococcus aureus Nuclease Is an SaeRS-Dependent Virulence Factor

Characterisation of convective regimes over the British Isles

Food-Related Stimuli Impair Inhibitory Control in Adults Classified As Overweight to Obese

Improvements in Forecasting Intense Rainfall: Results from the FRANC (Forecasting Rainfall Exploiting New Data Assimilation Techniques and Novel Observations of Convection) Project

Blood pressure treatment and outcomes in hypertensive patients without acute target organ damage: a retrospective cohort

Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling

Generalisable long COVID subtypes: findings from the NIH N3C and RECOVER programmes

Characterizing motor impulsivity of individuals classified as overweight to obese

Acute Exercise Increases Attentional Bias Towards Food Cues: 1963

Calorimeter R&D for the SuperNEMO double beta decay experiment

Gastrointestinal Bleeding With Edoxaban Versus Warfarin: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis In Myocardial Infarction)

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