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Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma

Nature communications, 2019-11, Vol.10 (1), p.5367-16, Article 5367

2019

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Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

Cell, 2016-01, Vol.164 (1-2), p.293-309

2016

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NMR-based functional profiling of RASopathies and oncogenic RAS mutations

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (12), p.4574-4579

2013

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Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

Cell, 2015-01, Vol.160 (1-2), p.88-104

2015

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SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models

Cancer discovery, 2018-10, Vol.8 (10), p.1237-1249

2018

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SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling

The Journal of experimental medicine, 2021-01, Vol.218 (1)

2021

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The tyrosine phosphatase Shp2 (PTPN11) in cancer

Cancer and metastasis reviews, 2008-06, Vol.27 (2), p.179-192

2008

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Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer

Cancer research (Chicago, Ill.), 2007-03, Vol.67 (6), p.2420-2424

2007

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Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and “Redoxome”

Cell, 2011-09, Vol.146 (5), p.826-840

2011

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Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition

The Journal of experimental medicine, 2023-05, Vol.220 (5)

2023

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SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver

Molecular cell, 2011-07, Vol.43 (1), p.45-56

2011

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Selective and noncovalent targeting of RAS mutants for inhibition and degradation

Nature communications, 2021-05, Vol.12 (1), p.2656-2656, Article 2656

2021

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The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

Trends in biochemical sciences (Amsterdam. Regular ed.), 2003-06, Vol.28 (6), p.284-293

2003

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Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

Proceedings of the National Academy of Sciences - PNAS, 2015-05, Vol.112 (21), p.6625-6630

2015

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Distinct Roles for Neutrophils and Dendritic Cells in Inflammation and Autoimmunity in motheaten Mice

Immunity (Cambridge, Mass.), 2013-03, Vol.38 (3), p.489-501

2013

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Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation

Nature communications, 2024-04, Vol.15 (1), p.2843-2843

2024

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Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor

Proceedings of the National Academy of Sciences - PNAS, 2018-01, Vol.115 (3), p.E468-E477

2018

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Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation

The Journal of clinical investigation, 2011-03, Vol.121 (3), p.1026-1043

2011

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Vitamin C in Stem Cell Reprogramming and Cancer

Trends in cell biology, 2018-09, Vol.28 (9), p.698-708

2018

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Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation

Cell reports (Cambridge), 2012-10, Vol.2 (4), p.951-963

2012

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Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2

Cell metabolism, 2014-07, Vol.20 (1), p.85-102

2014

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A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome

Molecular cell, 2017-01, Vol.65 (2), p.347-360

2017

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Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

Cell metabolism, 2011-11, Vol.14 (5), p.684-699

2011

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Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

Cancer discovery, 2022-04, Vol.12 (4), p.1022-1045

2022

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Both fallopian tube and ovarian surface epithelium are cells-of-origin for high-grade serous ovarian carcinoma

Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance

NMR-based functional profiling of RASopathies and oncogenic RAS mutations

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models

SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling

The tyrosine phosphatase Shp2 (PTPN11) in cancer

Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer

Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and “Redoxome”

Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition

The spliceosome is a therapeutic vulnerability in MYC-driven cancer

SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver

Selective and noncovalent targeting of RAS mutants for inhibition and degradation

The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site

Distinct Roles for Neutrophils and Dendritic Cells in Inflammation and Autoimmunity in motheaten Mice

Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation

Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor

Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation

Vitamin C in Stem Cell Reprogramming and Cancer

Regulation of CD133 by HDAC6 Promotes β-Catenin Signaling to Suppress Cancer Cell Differentiation

Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer

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