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Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930

Molecular cancer therapeutics, 2011-02, Vol.10 (2), p.360-371

2011

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CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors

Cancer research (Chicago, Ill.), 2011-01, Vol.71 (2), p.463-472

2011

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CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs

Clinical cancer research, 2012-10, Vol.18 (20), p.5650-5661

2012

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AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Clinical cancer research, 2012-07, Vol.18 (14), p.3912-3923

2012

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The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106

Molecular cancer therapeutics, 2010-01, Vol.9 (1), p.89-100

2010

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Discovery of 3‑Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors

Journal of medicinal chemistry, 2012-11, Vol.55 (22), p.10229-10240

2012

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Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases

The FEBS journal, 2008-06, Vol.275 (12), p.3099-3109

2008

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CCT241533 is a potent and selective inhibitor of CHK2 which potentiates the cytotoxicity of PARP inhibitors

Cancer research (Chicago, Ill.), 2011-01, Vol.71 (2), p.463-472

2011

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Abstract 928: The novel clinical candidate AT13148 is an oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity and demonstrates a mechanism of action distinct from AKT inhibitors

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.928-928

2012

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Abstract 3503: CCT241533 is a novel, potent and selective inhibitor of CHK2 and potentiates the cellular effects of PARP inhibitors

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.3503-3503

2010

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Abstract 3518: Preclinical pharmacology of the novel, potent & selective CHK1 inhibitor SAR-020106

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.3518-3518

2010

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Which way do you lean? Using slope aspect variations to understand Critical Zone processes and feedbacks

Earth surface processes and landforms, 2018-04, Vol.43 (5), p.1133-1154

2018

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Validity, Reliability, and Differential Item Functioning of English and French Versions of the 10-Item Connor-Davidson Resilience Scale in Systemic Sclerosis: A Scleroderma Patient-Centered Intervention Network Cohort Study

Arthritis care & research (2010), 2023-11, Vol.75 (11), p.2369-2378

2023

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Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial

Journal of allergy and clinical immunology, 2018-01, Vol.141 (1), p.269-278.e1

2018

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Multi-compartment T2 relaxometry using a spatially constrained multi-Gaussian model

PloS one, 2014-06, Vol.9 (6), p.e98391-e98391

2014

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Evaluation of Measurement Properties and Differential Item Functioning in the English and French Versions of the University of California, Los Angeles, Loneliness Scale-6: A Scleroderma Patient-Centered Intervention Network (SPIN) Study

Arthritis care & research (2010), 2023-10, Vol.75 (10), p.2158-2165

2023

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Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices

Glia, 2012-04, Vol.60 (4), p.541-558

2012

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Viral population analysis and minority-variant detection using short read next-generation sequencing

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2013-03, Vol.368 (1614), p.20120205

2013

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Hybridization between two high Arctic cetaceans confirmed by genomic analysis

Scientific reports, 2019-06, Vol.9 (1), p.7729-10, Article 7729

2019

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Genomic insights into rapid speciation within the world’s largest tree genus Syzygium

Nature communications, 2022-09, Vol.13 (1), p.5031-5031, Article 5031

2022

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Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium

Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (30)

2021

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Twelve-month outcomes of an Internet-based diabetes self-management support program

Patient education and counseling, 2012-04, Vol.87 (1), p.81-92

2012

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Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930

CCT241533 Is a Potent and Selective Inhibitor of CHK2 that Potentiates the Cytotoxicity of PARP Inhibitors

CCT244747 Is a Novel Potent and Selective CHK1 Inhibitor with Oral Efficacy Alone and in Combination with Genotoxic Anticancer Drugs

AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)‑5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)

The preclinical pharmacology and therapeutic activity of the novel CHK1 inhibitor SAR-020106

Discovery of 3‑Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors

Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma

CCT241533 is a potent and selective inhibitor of CHK2 which potentiates the cytotoxicity of PARP inhibitors

Abstract 928: The novel clinical candidate AT13148 is an oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity and demonstrates a mechanism of action distinct from AKT inhibitors

Abstract 3503: CCT241533 is a novel, potent and selective inhibitor of CHK2 and potentiates the cellular effects of PARP inhibitors

Abstract 3518: Preclinical pharmacology of the novel, potent & selective CHK1 inhibitor SAR-020106

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma

Which way do you lean? Using slope aspect variations to understand Critical Zone processes and feedbacks

Validity, Reliability, and Differential Item Functioning of English and French Versions of the 10-Item Connor-Davidson Resilience Scale in Systemic Sclerosis: A Scleroderma Patient-Centered Intervention Network Cohort Study

Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial

Multi-compartment T2 relaxometry using a spatially constrained multi-Gaussian model

Evaluation of Measurement Properties and Differential Item Functioning in the English and French Versions of the University of California, Los Angeles, Loneliness Scale-6: A Scleroderma Patient-Centered Intervention Network (SPIN) Study

Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices

Viral population analysis and minority-variant detection using short read next-generation sequencing

Hybridization between two high Arctic cetaceans confirmed by genomic analysis

Genomic insights into rapid speciation within the world’s largest tree genus Syzygium

Chromosome 10q26-driven age-related macular degeneration is associated with reduced levels of HTRA1 in human retinal pigment epithelium

Twelve-month outcomes of an Internet-based diabetes self-management support program

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